The frequency of the H402 allele of CFH and its involvement with age-related maculopathy in an aged Black African Xhosa population

Ophthalmic Genetics

Volumn 29, Issue 3, 2008, Pages 117-119

  Ziskind, Ari ^a,d   Bardien, Soraya ^a   Van Der Merwe, Lize ^b   Webster, Andrew R ^c  

^a UNIVERSITY OF STELLENBOSCH   (South Africa)

^b SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^c MOORFIELDS EYE HOSPITAL   (United Kingdom)

^d STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

Black African Xhosa population; CFH gene; Y402H

Indexed keywords

AFRICA SOUTH OF THE SAHARA; ARTICLE; CFH GENE; CONTROLLED STUDY; DNA POLYMORPHISM; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION;

AFRICAN CONTINENTAL ANCESTRY GROUP; AGED; AGED, 80 AND OVER; ALLELES; COMPLEMENT FACTOR H; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; MACULAR DEGENERATION; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; SOUTH AFRICA;

EID: 51049115745     PISSN: 13816810     EISSN: 17445094     Source Type: Journal    
DOI: 10.1080/13816810802216472     Document Type: Article

References (11)

1. Thakkinstian A, Han P, McEvoy M, et al. Systematic review and meta-analysis of the association between complementary factor H Y402H polymorphisms and age-related macular degeneration. Hum Mol Genet. 2006;15:2784-2790.
2. Gregor Z, Joffe L. Senile macular changes in the black African. Br J Ophthalmol. 1978;62:547-550.
3. Friedman DS, Katz J, Bressler NM, Rahmani B, Tielsch JM. Racial differences in the prevalence of age-related macular degeneration: The Baltimore Eye Survey. Ophthalmology. 1999;106:1049-1055.
4. Leske MC, Wu SY, Hennis A, et al. Barbados Eye Studies Group. Nine-year incidence of age-related macular degeneration in the Barbados Eye Studies. Ophthalmology. 2006;113:29-35.
5. Stoneking M, Soodyall H. Human evolution and the mitochondrial genome. Curr Opin Genet Dev. 1996;6:731-736.
6. Despriet DD, Klaver CC, Witteman JC, et al. Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration. JAMA 2006;296:301-309.
7. Corfield VA, Moolman JC, Martell R, Brink PA. Polymerase chain reaction-based detection of MN blood group-specific sequences in the human genome. Transfusion. 1993;33:119-124.
8. Barondes M, Pauleikhoff D, Chisholm IC, Minassian D, Bird AC. Bilaterality of drusen. Br J Ophthalmol. 1990;74:180-182.
9. Gotoh N, Yamada R, Hiratani H, et al. No association between complement factor H gene polymorphism and exudative age-related macular degeneration in Japanese. Hum Genet. 2006;120:139-143.
10. Grassi MA, Fingert JH, Scheetz TE, et al. Ethnic variation in AMD-associated complement factor H polymorphism p.Tyr402His. Hum Mutat. 2006;27:921-925.
11. Magnusson KP, Duan S, Sigurdsson H, et al. CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD. PLoS Medicine. 2006;3:e5, 0109-0114.