M2 muscarinic receptors induce airway smooth muscle activation via a dual, Gβγ-mediated inhibition of large conductance Ca 2+-activated K+ channel activity

Journal of Biological Chemistry

Volumn 283, Issue 30, 2008, Pages 21036-21044

  Zhou, Xiao Bo ^a   Wulfsen, Iris ^a   Lutz, Susanne ^c   Utku, Emine ^a   Sausbier, Ulrike ^b   Ruth, Peter ^b   Wieland, Thomas ^c   Korth, Michael ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; FLOW INTERACTIONS; MUSCLE; PURIFICATION;

AIRWAY SMOOTH MUSCLES; BK CHANNELS; CHANNEL ACTIVITIES; CHANNEL OPEN PROBABILITIES; EFFECTIVE CONCENTRATIONS; HEK293 CELLS; IMMUNOPRECIPITATION; MUSCARINIC RECEPTORS; OVEREXPRESSION; PERTUSSIS TOXINS; PHOSPHOLIPASE; PHYSICAL INTERACTIONS; PROTEIN KINASES; TRANSDUCIN; UNDERLYING MECHANISMS; WHOLE CELLS;

CALCIUM;

CARBACHOL; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; MUSCARINIC M2 RECEPTOR; PERTUSSIS TOXIN; PHOSPHOLIPASE C; PROTEIN KINASE C; SCAVENGER; TRANSDUCIN; TRANSDUCIN ALPHA; UNCLASSIFIED DRUG; CALCIUM; CALCIUM ACTIVATED POTASSIUM CHANNEL; MUSCARINIC RECEPTOR; POTASSIUM;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BREATHING MUSCLE; CELL STRAIN HEK293; CONCENTRATION (PARAMETERS); ENZYME ACTIVITY; HUMAN; IMMUNOPRECIPITATION; INHIBITION KINETICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; SMOOTH MUSCLE; TRACHEA; WHOLE CELL; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CHEMISTRY; FEMALE; MALE; METABOLISM;

BOVINAE;

ANIMALS; CALCIUM; FEMALE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; MUSCLE, SMOOTH; POTASSIUM; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; PROTEIN KINASE C; RECEPTORS, MUSCARINIC; TRACHEA; TYPE C PHOSPHOLIPASES;

EID: 51049109460     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800447200     Document Type: Article

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