Substrate recognition mechanism of VAMP/synaptobrevin-cleaving clostridial neurotoxins

Journal of Biological Chemistry

Volumn 283, Issue 30, 2008, Pages 21145-21152

  Sikorra, Stefan ^a   Henke, Tina ^a   Galli, Thierry ^b,c   Binz, Thomas ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b INSERM   (France)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; BINDING SITES; FLOW INTERACTIONS; PORT TERMINALS;

BOTULINUM NEUROTOXINS; CATALYTIC PROCESSES; CLEAVAGE SITES; DIFFERENT SIZES; DIFFERENT SUBSTRATES; EXOSITES; MEMBRANE PROTEINS; NEUROTRANSMITTER RELEASES; PEPTIDE BONDS; PRIOR WORKS; PROTEIN RECEPTORS; SCISSILE BONDS; SNAP-25; SUBSTRATE BINDINGS; SUBSTRATE INTERACTIONS; SUBSTRATE RECOGNITIONS; SYNAPTIC VESICLES; SYNAPTOBREVIN; SYNTAXIN; TERMINAL SITES; TETANUS NEUROTOXINS; TURNOVER NUMBERS;

SUBSTRATES;

BACTERIAL TOXIN; BOTULINUM TOXIN; BOTULINUM TOXIN B; BOTULINUM TOXIN D; BOTULINUM TOXIN F; MEMBRANE PROTEIN; NEUROTOXIN; SYNAPTOBREVIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; TETANUS NEUROTOXIN; TETANUS TOXIN; UNCLASSIFIED DRUG; PEPTIDE; RECOMBINANT PROTEIN; SYNAPTOBREVIN 2;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CLOSTRIDIUM; ENZYMATIC DEGRADATION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HUMAN; MOLECULAR RECOGNITION; MUTAGENESIS; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; ENZYME SPECIFICITY; GENETIC TRANSCRIPTION; KINETICS; METABOLISM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; RAT;

ANIMALS; HUMANS; KINETICS; MODELS, BIOLOGICAL; MUTAGENESIS; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; R-SNARE PROTEINS; RATS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TETANUS TOXIN; TRANSCRIPTION, GENETIC; VESICLE-ASSOCIATED MEMBRANE PROTEIN 2;

EID: 51049104533     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800610200     Document Type: Article

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