Systemic cytokine profiles of mice vaccinated with naked DNAs encoding six open reading frame antigens of porcine circovirus type 2 (PCV2)

Research in Veterinary Science

Volumn 85, Issue 3, 2008, Pages 503-509

  An, Dong Jun ^a   Song, Dae Sub ^b   Park, Bong Kyun ^c  

^a Animal Plant and Fisheries Quarantine and Inspection Agency   (South Korea)

^b Green Cross Veterinary Products Co LTD   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Cytokine profile; ORFs; PCV2

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; MESSENGER RNA; NAKED DNA; TUMOR NECROSIS FACTOR ALPHA; VIRUS ANTIGEN;

ANIMAL EXPERIMENT; ARTICLE; CELL STRAIN HEK293; CIRCOVIRIDAE; CONTROLLED STUDY; CYTOKINE RELEASE; DNA IMMUNIZATION; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNE RESPONSE; LETHALITY; MOUSE; NONHUMAN; OPEN READING FRAME; PORCINE CIRCOVIRUS TYPE 2; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TH1 CELL; TH2 CELL;

ANIMALS; ANTIGENS, VIRAL; CIRCOVIRIDAE INFECTIONS; CIRCOVIRUS; CYTOKINES; DNA, VIRAL; INTERLEUKIN-12; MICE; OPEN READING FRAMES; SWINE; SWINE DISEASES; TUMOR NECROSIS FACTOR-ALPHA; VIRAL VACCINES;

MURINAE; MUS; PORCINE CIRCOVIRUS 2;

EID: 51049099134     PISSN: 00345288     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rvsc.2008.03.006     Document Type: Article

References (26)

1. Albina E., Truong C., Hutet E., Blanchard P., Cariolet R., L'Hospitalier R., Mahe D., Allee C., Morvan H., Amenna N., Le Dimna M., Madec F., and Jestin A. An experimental model for post-weaning multisystemic wasting syndrome (PMWS) in growing piglets. J. Comp. Pathol. 125 (2001) 292-303
2. Allan G.M., and Ellis J.A. Porcine circoviruses: a review. J. Vet. Diagn. Invest. 12 (2000) 3-14
3. Allan G.M., McNeilly F., Kennedy S., Meehan B., Ellis J., and Krakowka S. Immunostimulation, PCV-2 and PMWS. Vet. Rec. 147 (2000) 170-171
4. An D.J., Ro I.S., Song D.S., Park C.K., and Park B.K. Phylogenetic characterization of porcine circoviurs type 2 in PMWS and PDNS Korean pigs between 1999 and 2006. Virus. Res. 129 (2007) 115-122
5. Cheung A.K. Transcriptional analysis of porcine circovirus type 2. Virology 305 (2003) 168-180
6. Darwich L., Balasch M., Plana-Duran J., Segales J., Domingo M., and Mateu E. Cytokine profiles of peripheral blood mononuclear cells from pigs with postweaning multisystemic wasting syndrome in response to mitogen, superantigen or recall viral antigens. J. Gen. Virol. 84 (2003) 3453-3457
7. Darwich L., Pie S., Rovira A., Segales J., Domingo M., Oswald I.P., and Mateu E. Cytokine mRNA expression profiles in lymphoid tissues of pigs naturally affected by postweaning multisystemic wasting syndrome. J. Gen. Virol. 84 (2003) 2117-2125
8. Dinarello C. Proinflammatory cytokines. Chest 118 (2000) 503-508
9. Fynan E.F., Webster R.G., Fuller D.H., Haynes J.R., Santoro J.C., and Robinson H.L. DNA vaccines: protective immunizations by parental, mucosal and gene-gun inoculation. Proc. Natl. Acad. Sci. USA 90 (1993) 11478-11482
10. Hamel A.L., Lin L.L., and Nayer G.P. Nucleotide sequence of porcine circovirus associated with postweaning multisystemic wasting syndrome in pigs. J. Virol. 72 (1998) 5262-5267
11. Kamstrup S., Barfoed A.M., Frimann T.H., Ladekjaer-Mikkelsen A.S., and Bøtner A. Immunisation against PCV2 structural protein by DNA vaccination of mice. Vaccine 29 (2004) 1358-1361
12. Kim J., and Chae C. Expression of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 in porcine circovirus 2-induced granulomatous inflammation. J. Comp. Pathol. 131 (2004) 121-126
13. Kim J., Ha Y., and Chae C. Potentiation of porcine circovirus 2-induced postweaning multisystemic wasting syndrome by porcine parvovirus is associated with excessive production of tumor necrosis factor-α. Vet. Pathol. 43 (2006) 718-725
14. Krakowka S., Ellis J.A., McNeilly F., Ringler S., Rings D.M., and Allan G. Activation of the immune system is the pivotal event in the production of wasting disease in pigs infected with porcine circovirus-2 (PCV-2). Vet. Pathol. 38 (2001) 31-42
15. Letellier A.L.E., Kerkhofs P., Wellemans G., and Vanopdenbosch E. Detection and genotyping of bovine diarrhea virus by reverse transcription-polymerase chain amplification of the 5′untransclated region. Vet. Microbiol. 64 (1999) 155-167
16. Liu J., Chen I., Du Q., Chua H., and Kwang J. The ORF3 protein of porcine circovirus type 2 is involved in viral pathogenesis in vivo. J. Virol. 80 (2006) 5065-5073
17. Mankertz A., Caliskan R., Hattermann K., Hillenbrand B., Kurzendoerfer P., Mueller B., Schmitt C., Steinfeldt T., and Finsterbusch T. Molecular biology of Porcine circovirus: analyses of gene expression and viral replication. Vet. Microbiol. 98 (2004) 81-88
18. Nielsen J., Vincent I.E., Botner A., Ladekjaer-Mikkelsen A.S., Allan G., Summerfield A., and MaCullough K.C. Association of lymphopenia with porcine circovirus type 2 induced postweaning multisystemic wasting syndrome (PMWS). Vet. Immunol. Immunopathol. 92 (2003) 97-111
19. Rovira A., Balasch M., Segales J., Garci L., Plana-Duran J., Rosell C., Ellerbrok H., Mankertz A., and Domingo M. Experimental inoculation of conventional pigs with porcine reproductive and respiratory syndrome virus and porcine circovirus 2. J. Virol. 76 (2002) 3232-3239
20. Sasaki S., Takeshita F., Xin K.Q., Ishii N., and Okuda K. Adjuvant formulations and delivery systems for DNA vaccines. Methods 31 (2003) 243-254
21. Segales J., Alonso F., Rosell C., Pastor J., Chianini F., Campos E., Lopez-Fuertes L., Quintana J., Rodriguez-Arrioja G., Calsamiglia M., Pujols J., Dominguez J., and Domingo M. Changes in peripheral blood leukocyte populations in pigs with natural postweaning multisystemic wasting syndrome (PMWS). Vet. Immunol. Immunopathol. 81 (2001) 37-44
22. Sipos W., Duvigneau J.C., Willheim M., Schilcher F., Hartl R.T., Hofbauer G., Exel B., Pietschmann P., and Schmoll F. Systemic cytokine profile in feeder pigs suffering from natural postweaning multisystemic wasting syndrome (PMWS) as determined by semiquantitative RT-PCR and flow cytometric intracellular cytokine detection. Vet. Immunol. Immunopathol. 99 (2004) 63-71
23. Sipos W., Duvigneau J.C., Pietschmann P., Schilcher F., Hofbauer G., Hartl R.T., and Schmoll F. Porcine dermatitis and nephropathy syndrome (PDNS) is associated with a systemic cytokine expression profile indicative of proinflammation and a Th1 bias. Vet. Immunol. Immunopathol. 107 (2005) 303-313
24. Stevenson L.S., McCullough K., Vincent I., Gilpin D.F., Summerfield A., Nielsen J., McNeilly F., Adair B.M., and Allan G.M. Cytokine and C-reactive protein profiles induced by porcine circovirus type 2 experimental infection in 3-week-old piglets. Viral Immunol. 19 (2006) 189-195
25. Ulmer J., Sadoff J., and Liu M.A. DNA vaccines. Curr. Opin. Immunol. 8 (1996) 531-536
26. Wolff J.A., Malone R.W., Williams P., Chong W., Ascadi G., and Jani A. Direct gene transfer into mouse muscle cells in vivo. Science 247 (1990) 1465-1468