In-Vitro anti-HIV and antitumor activity of new 3,6-disubstituted [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles and thiadiazine analogues

Archiv der Pharmazie

Volumn 341, Issue 6, 2008, Pages 365-369

  Al Soud, Yaseen A ^a   Al Masoudi, Najim A ^b,d   Loddo, Robert ^c   La Colla, Paola ^c  

^a AL AL BAYT UNIVERSITY   (Jordan)

^b UNIVERSITY OF KONSTANZ   (Germany)

^c UNIVERSITY OF CAGLIARI   (Italy)

^d NONE   (Germany)

Author keywords

Anti HIV activity; Antitumor activity; Microwave assisted synthesis; Thiadiazines; Triazolothiadiazoles

Indexed keywords

3 (3 BROMOPHENYL) 6 (3,4 DICHLOROPHENYL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOLE; 3 (3,4 DICHLOROPHENYL) 6 (FURAN 2 YL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOLE; 3 (3,4 DICHLOROPHENYL) 6 (PYRAZIN 2 YL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOLE; 3 (3,4 DICHLOROPHENYL) 6 (PYRIDIN 3 YL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOLE; 3 (3,4 DICHLOROPHENYL) 6 (PYRROL 2 YL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOLE; 3 (3,4 DICHLOROPHENYL) 6 (THIOPHEN 2 YL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOLE; 3 (3,4 DICHLOROPHENYL) 6 PHENYL[1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZINE; 3 (3,4 DICHLOROPHENYL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZIN 6 AMINE; 3 (3,4 DICHLOROPHENYL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZIN 6 ONE; 3 (4 AMINOPHENYL) 6 (COUMARIN 3 YL) [1,2,4]TRIAZOLO[3,4 B][1,3,.4]THIADIAZOLE; 3,6 BIS(3,4 DICHLOROPHENYL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOLE; 6 (4 AMINOPHENYL) 3 (3,4 DICHLOROPHENYL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOLE; THIADIAZINE DERIVATIVE; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTINEOPLASTIC AGENT; TRIAZOLE DERIVATIVE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CD4+ T LYMPHOCYTE; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; IN VITRO STUDY; MICROWAVE IRRADIATION; NONHUMAN; PRIORITY JOURNAL; TUMOR CELL LINE; CELL LINE; DRUG EFFECT; DRUG SCREENING; STRUCTURE ACTIVITY RELATION; SYNTHESIS; T LYMPHOCYTE; VIROLOGY;

ANTI-HIV AGENTS; ANTINEOPLASTIC AGENTS; CELL LINE; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HIV-1; HIV-2; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES; THIADIAZINES; THIADIAZOLES; TRIAZOLES;

EID: 50949096365     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200700272     Document Type: Article

References (25)

1. J. Mohan, G. S. R. Anjaneyulug, Curr. Sci. 1989, 58, 1028-1030.
2. M. M. Ghorab, A. M. Sh. El-Sharief, Y. A. Ammar, Sh. I. Mohamed, Phosphorus Sulfur Silicon Relat. Elem. 2001, 173, 223-233.
3. B. S. Holla, P. M. Akberali, M. K. Shivananda, Farmaco 2001, 56, 919-927.
4. E. Palaska, G. Sahin, P. Kelicen, N. T. Durlu, G. Altinok, Farmaco 2002, 57, 101-107.
5. L. Labanauskas, V. Kalcas, E. Udrenaite, P. Gaidelis, et al., Pharmazie 2001, 56, 617-619.
6. A. Foroumadi, M. Mirzaei, A. Shafiee, Pharmazie 2001, 56, 610-612.
7. V. K. Chadha, N. S. Ranwa, P. K. Dadheech, J. Phytol. Res. 1998, 11, 201-202.
8. N. Demirbas, A. Demirbas, S. A. Karaoglu, E. Çelik, ARKIVOC 2005, i, 75-91.
9. B. S. Holla, K. N. Poojary, B. S. Rao, M. K. Shivananda, Eur. J. Med. Chem. 2002, 37, 511-517.
10. K. S. Bhat, D. J. Prasad, B. Poojary, S. Holla, Phosphorus Sulfur Silicon Relat. Elem. 2004, 179, 1595-1603.
11. K. Marina, M. Anastssia, M. Panagiotis, P. Nicole, et al., Farmaco 2002, 57, 253-257.
12. M. Sakata, Y. Shirakawa, N. Kamata, Y. S. Hiroshino, O. Y. Jie, J. Heterocycl. Chem. 2000, 37, 269-271.
13. G. M. Nizamuddin, M. H. Khan, M. K. Srivastava, J. Sci. Ind. Res. 1999, 58, 538-542.
14. F. P. Invidiata, D. Simoni, F. Scintu, N. Pinna, Farmaco 1996, 51, 659-664.
15. N. D. Heindel, J. R. Reid, J. Heterocycl. Chem. 1980, 17, 1087-1088.
16. B. S. Goswami, J. C. S. Kataky, J. N. Baruah, J. Heterocycl. Chem. 1986, 23, 1439-1442.
17. K. S. Rao, C. V. R. Sastry, Ind. J. Pharm. Sci. 1993, 55, 108-110.
18. B. A. Nadkarni, V. R. Kamat, B. G. Khadse, Arzneimittelforschung 2001, 51, 569-573.
19. R. M. Shaker, ARKIVOC 2006, ix, 59-112.
20. I. A. Al-Masoudi, Y. A. Al-Soud, N. J. Al-Salihi, N. A. Al-Masoudi, Chem. Heterocycl. Comp. 2006, 467, 1635-1646.
21. Y. A. Al-Soud, N. A. Al-Masoudi, T. Schuppler, E. De Clercq, C. Pannecouque, (Part 1), Nucleos. Nucleot. Nucleic Acids, 2008, 27(5), accepted; N. A. Al-Masoudi, Y. A. Al-Soud, (Part 2), in press.
22. R. Pauwels, J. Balzarini, M. Baba, R. Snoeck, et al., J. Virol. Methods 1988, 20, 309-321.
23. S. D. Young, S. F. Britcher, L. O. Tran, L. S. Payne, et al., Antimicrob. Agents Chemother 1995, 39, 2602-2605.
24. T. Fujiwara, A. Sato, M. El-Farrash, S. Miki, et al., Antimicrob. Agents Chemother. 1998, 42, 1340-1345.
25. N. F. Eweiss, A. A. Bahajaj, E. A. Elsherbini, J. Heterocycl. Chem. 1986, 23, 1451-1458.