Development of catheter-directed intrathrombus thrombolysis with plasmin for the treatment of acute lower extremity arterial occlusion

Thrombosis Research

Volumn 122, Issue SUPPL. 3, 2008, Pages

  Comerota, Anthony J ^a  

^a JOBST VASCULAR CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALFIMEPRASE; HEPARIN; PLASMIN; TISSUE PLASMINOGEN ACTIVATOR; UROKINASE;

ANKLE BRACHIAL INDEX; ARTERY CATHETERIZATION; ARTERY OCCLUSION; ARTICLE; BLEEDING; BLOOD CLOT LYSIS; BRAIN HEMORRHAGE; CLINICAL TRIAL; CONTINUOUS INFUSION; DOSE RESPONSE; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG HALF LIFE; DRUG WITHDRAWAL; GUIDE WIRE; HUMAN; HYPOTENSION; INTERMITTENT CLAUDICATION; LEG AMPUTATION; LEG ISCHEMIA; LOW DRUG DOSE; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PRIORITY JOURNAL; SYSTEMIC CIRCULATION; UNSPECIFIED SIDE EFFECT;

ARTERIAL OCCLUSIVE DISEASES; CATHETERIZATION; FIBRINOLYTIC AGENTS; HUMANS; LEG; LIMB SALVAGE; PLASMIN; THROMBOSIS;

EID: 50849125709     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2008.06.012     Document Type: Article

References (17)

1. Alkjaersig N., Fletcher A.P., and Sherry S. The mechanism of clot dissolution by plasmin. J Clin Invest 38 7 (1959) 1086-1095
2. McNamara T.O., and Fischer J.R. Thrombolysis of peripheral arterial and graft occlusions: improved results using high-dose urokinase. AJR Am J Roentgenol 144 (1985) 769-775
3. Ouriel K., Shortell C.K., Azodo M.V., Guiterrez O.H., and Marder V.J. Acute peripheral arterial occlusion: predictors of success in catheter-directed thrombolytic therapy. Radiology 193 (1994) 561-566
4. Gardiner Jr. G.A., Harrington D.P., Koltun W., Whittemore A., Mannick J.A., and Levin D.C. Salvage of occluded arterial bypass grafts by means of thrombolysis. J Vasc Surg 9 (1989) 426-431
5. McNamara T.O., and Bomberger R.A. Factors affecting initial and 6 month patency rates after intraarterial thrombolysis with high dose urokinase. Am J Surg 152 (1986) 709-712
6. Sullivan K.L., Gardiner Jr. G.A., Shapiro M.J., Bonn J., and Levin D.C. Acceleration of thrombolysis with a high-dose transthrombus bolus technique. Radiology 173 (1989) 805-808
7. Ward A.S., Andaz S.K., and Bygrave S. Thrombolysis with tissue-plasminogen activator: results with a high-dose transthrombus technique. J Vasc Surg 19 (1994) 503-508
8. Kandarpa K. Technical determinants of success in catheter-directed thrombolysis for peripheral arterial occlusions. J Vasc Interv Radiol 6 (1995) 55S-61S
9. Berridge D.C., Gregson R.H., Hopkinson B.R., and Makin G.S. Randomized trial of intra-arterial recombinant tissue plasminogen activator, intravenous recombinant tissue plasminogen activator and intra-arterial streptokinase in peripheral arterial thrombolysis. Br J Surg 78 (1991) 988-995
10. Ouriel K., Shortell C.K., DeWeese J.A., Green R.M., Francis C.W., Azodo M.V., Gutierrez O.H., et al. A comparison of thrombolytic therapy with operative revascularization in the initial treatment of acute peripheral arterial ischemia. J Vasc Surg 19 (1994) 1021-1030
11. Ouriel K., Veith F.J., and Sasahara A.A. A comparison of recombinant urokinase with vascular surgery as initial treatment for acute arterial occlusion of the legs. Thrombolysis or Peripheral Arterial Surgery (TOPAS) Investigators. N Engl J Med 338 (1998) 1105-1111
12. Results of a prospective randomized trial evaluating surgery versus thrombolysis for ischemia of the lower extremity. The STILE trial. Ann Surg 220 (1994) 251-266 discussion 266-258
13. Plate G., Jansson I., Forssell C., Weber P., and Oredsson S. Thrombolysis for acute lower limb ischaemia-a prospective, randomised, multicentre study comparing two strategies. Eur J Vasc Endovasc Surg 31 (2006) 651-660
14. Ouriel K., Cynamon J., Weaver F.A., Dardik H., Akers D., Blebea J., et al. A phase I trial of alfimeprase for peripheral arterial thrombolysis. J Vasc Interv Radiol 16 (2005) 1075-1083
15. Weaver FA, Perler BA, Levy MD, et al. Efficacy and safety of alfimeprase in subjects with acute peripheral arterial occlusion (PAO): the NAPA phase 3 program. Poster presented at: International Society of Endovascular Therapy (ISET); January 18-22, 2008; Hollywood, Fl.
16. Marder V.J., Landskroner K., Novokhatny V., Zimmerman T.P., Kong M., Kanouse J.J., et al. Plasmin induces local thrombolysis without causing hemorrhage: a comparison with tissue plasminogen activator in the rabbit. Thromb Haemost 86 (2001) 739-745
17. Shlansky-Goldberg R., Matsumoto A.H., Baumbach G.A., Siegel J.B., Raabe R.D., Murphy T.P., et al. A first-in-human phase 1 trial of locally delivered human plasmin for hemodialysis graft occlusion. J Thromb Haemost 6 (2008) 944-950