Thrombolysis for Acute Lower Limb Ischaemia-A Prospective, Randomised, Multicentre Study Comparing Two Strategies

European Journal of Vascular and Endovascular Surgery

Volumn 31, Issue 6, 2006, Pages 651-660

  Plate, G ^a   Jansson, I ^b   Forssell, C ^c   Weber, P ^d   Oredsson, S ^a  

^a HELSINGBORG HOSPITAL   (Sweden)

^b Department of Mammography   (Sweden)

^c CENTRAL HOSPITAL   (Sweden)

^d CENTRAL HOSPITAL   (Sweden)

Author keywords

Acute limb ischaemia; Adverse effects; Arterial occlusive disease; Fibrinolytic agents; Lower extremity; Recombinant tissue plasminogen activator; Thrombolytic therapy

Indexed keywords

ALTEPLASE; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN;

ADULT; AGED; ANALYTICAL ERROR; ARTERY REOCCLUSION; ARTICLE; BLEEDING; CARDIOTOXICITY; CEREBROVASCULAR ACCIDENT; CLINICAL TRIAL; COMPARTMENT SYNDROME; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG MEGADOSE; DRUG WITHDRAWAL; EMBOLISM; FEMALE; FIBRINOLYTIC THERAPY; FREQUENCY ANALYSIS; GASTROINTESTINAL HEMORRHAGE; HEALTH ECONOMICS; HEMATURIA; HUMAN; LEG AMPUTATION; LEG ANGIOGRAPHY; LEG ISCHEMIA; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MEDICAL DOCUMENTATION; MORTALITY; MULTICENTER STUDY; OUTCOMES RESEARCH; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; STENT; STROKE; THROMBOSIS; VASCULAR PATENCY;

AGED; AGED, 80 AND OVER; DRUG ADMINISTRATION SCHEDULE; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; ISCHEMIA; LOWER EXTREMITY; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RECOMBINANT PROTEINS; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME;

EID: 33646915483     PISSN: 10785884     EISSN: 15322165     Source Type: Journal    
DOI: 10.1016/j.ejvs.2005.11.017     Document Type: Article

References (36)

1. Blaisdell F.W., Steele M., and Allen R.E. Management of acute lower extremity arterial ischemia due to embolism and thrombosis. Surgery 84 6 (1978) 822-834
2. Yeager R.A., Moneta G.L., Taylor Jr. L.M., Hamre D.W., McConnell D.B., and Porter J.M. Surgical management of severe acute lower extremity ischemia. J Vasc Surg 15 2 (1992) 385-391 [discussion 392-393]
3. Diffin D.C., and Kandarpa K. Assessment of peripheral intraarterial thrombolysis versus surgical revascularization in acute lower-limb ischemia: a review of limb-salvage and mortality statistics. J Vasc Interv Radiol 7 1 (1996) 57-63
4. Tillett W.S., Johnson A.J., and Mc C.W. The intravenous infusion of the streptococcal fibrinolytic principle (streptokinase) into patients. J Clin Invest 34 2 (1955) 169-185
5. Boyles P.W., Meyer W.H., Graff J., Ashley C.C., and Ripic R.G. Comparative effectiveness of intravenous and intra-arterial fibrinolysin therapy. Am J Cardiol 6 (1960) 439-446
6. Earnshaw J.J., Hopkinson B.R., and Makin G.S. Acute critical ischaemia of the limb: a prospective evaluation. Eur J Vasc Surg 4 4 (1990) 365-368
7. Berridge D.C., Gregson R.H., Hopkinson B.R., and Makin G.S. Randomized trial of intra-arterial recombinant tissue plasminogen activator, intravenous recombinant tissue plasminogen activator and intra-arterial streptokinase in peripheral arterial thrombolysis. Br J Surg 78 8 (1991) 988-995
8. DeMaioribus C.A., Mills J.L., Fujitani R.M., Taylor S.M., and Joseph A.E. A reevaluation of intraarterial thrombolytic therapy for acute lower extremity ischemia. J Vasc Surg 17 5 (1993) 888-895
9. Comerota A.J., Weaver F.A., Hosking J.D., Froehlich J., Folander H., Sussman B., et al. Results of a prospective, randomized trial of surgery versus thrombolysis for occluded lower extremity bypass grafts. Am J Surg 172 2 (1996) 105-112
10. Weaver F.A., Comerota A.J., Youngblood M., Froehlich J., Hosking J.D., and Papanicolaou G. Surgical revascularization versus thrombolysis for nonembolic lower extremity native artery occlusions: results of a prospective randomized trial. The STILE investigators. Surgery versus thrombolysis for ischemia of the lower extremity. J Vasc Surg 24 4 (1996) 513-521 [discussion 521-523]
11. Results of a prospective randomized trial evaluating surgery versus thrombolysis for ischemia of the lower extremity. The STILE trial. Ann Surg 1994;220(3):251-266 [discussion 266-268].
12. Ouriel K., Veith F.J., and Sasahara A.A. Thrombolysis or peripheral arterial surgery: phase I results. TOPAS Investigators. J Vasc Surg 23 1 (1996) 64-73 [discussion 74-75]
13. Weaver F.A., and Toms C. The practical implications of recent trials comparing thrombolytic therapy with surgery for lower extremity ischemia. Semin Vasc Surg 10 1 (1997) 49-54
14. McNamara T.O., and Fischer J.R. Thrombolysis of peripheral arterial and graft occlusions: improved results using high-dose urokinase. AJR Am J Roentgenol 144 4 (1985) 769-775
15. Sullivan K.L., Gardiner Jr. G.A., Shapiro M.J., Bonn J., and Levin D.C. Acceleration of thrombolysis with a high-dose transthrombus bolus technique. Radiology 173 3 (1989) 805-808
16. Valji K., Bookstein J.J., Roberts A.C., Oglevie S.B., Pittman C., and O'Neill M.P. Pulse-spray pharmacomechanical thrombolysis of thrombosed hemodialysis access grafts: long-term experience and comparison of original and current techniques. AJR Am J Roentgenol 164 6 (1995) 1495-1500 [discussion 1501-1503]
17. Armon M.P., Yusuf S.W., Whitaker S.C., Gregson R.H., Wenham P.W., and Hopkinson B.R. Results of 100 cases of pulse-spray thrombolysis for acute and subacute leg ischaemia. Br J Surg 84 1 (1997) 47-50
18. Kandarpa K., Chopra P.S., Aruny J.E., Polak J.F., Donaldson M.C., Whittemore A.D., et al. Intraarterial thrombolysis of lower extremity occlusions: prospective, randomized comparison of forced periodic infusion and conventional slow continuous infusion. Radiology 188 3 (1993) 861-867
19. Braithwaite B.D., Buckenham T.M., Galland R.B., Heather B.P., and Earnshaw J.J. Prospective randomized trial of high-dose bolus versus low-dose tissue plasminogen activator infusion in the management of acute limb ischaemia. Thrombolysis Study Group. Br J Surg 84 5 (1997) 646-650
20. Patel N., Sacks D., Patel R.I., Moresco K.P., Ouriel K., Gray R., et al. SIR reporting standards for the treatment of acute limb ischemia with use of transluminal removal of arterial thrombus. J Vasc Interv Radiol 14 9 Pt 2 (2003) S453-S465
21. Working Party on Thrombolysis in the management of limb ischemia. Thrombolysis in the management of lower limb peripheral arterial occlusion-a consensus document. J Vasc Interv Radiol 2003;14(9 Pt 2):S337-S349.
22. Palfreyman S.J., Booth A., and Michaels J.A. A systematic review of intra-arterial thrombolytic therapy for lower-limb ischaemia. Eur J Vasc Endovasc Surg 19 2 (2000) 143-157
23. Kandarpa K., Becker G.J., Hunink M.G., McNamara T.O., Rundback J.H., Trost D.W., et al. Transcatheter interventions for the treatment of peripheral atherosclerotic lesions. Part I. J Vasc Interv Radiol 12 6 (2001) 683-695
24. Berridge D.C., Kessel D., and Robertson I. Surgery versus thrombolysis for acute limb ischaemia: initial management. Cochrane Database Syst Rev 3 (2002) CD002784
25. Swischuk J.L., Fox P.F., Young K., Hussain S., Smouse B., Castaneda F., et al. Transcatheter intraarterial infusion of rt-PA for acute lower limb ischemia: results and complications. J Vasc Interv Radiol 12 4 (2001) 423-430
26. Nehler M.R., Mueller R.J., McLafferty R.B., Johnson S.P., Nussbaum J.D., Mattos M.A., et al. Outcome of catheter-directed thrombolysis for lower extremity arterial bypass occlusion. J Vasc Surg 37 1 (2003) 72-78
27. Eliason J.L., Wainess R.M., Proctor M.C., Dimick J.B., Cowan Jr. J.A., Upchurch Jr. G.R., et al. A national and single institutional experience in the contemporary treatment of acute lower extremity ischemia. Ann Surg 238 3 (2003) 382-389 [discussion 389-390]
28. Mahler F., Schneider E., and Hess H. Recombinant tissue plasminogen activator versus urokinase for local thrombolysis of femoropopliteal occlusions: a prospective, randomized multicenter trial. J Endovasc Ther 8 6 (2001) 638-647
29. Kessel D.O., Berridge D.C., and Robertson I. Infusion techniques for peripheral arterial thrombolysis. Cochrane Database Syst Rev 1 (2004) CD000985
30. Earnshaw J.J., Whitman B., and Foy C. National Audit of Thrombolysis for Acute Leg Ischemia (NATALI): clinical factors associated with early outcome. J Vasc Surg 39 5 (2004) 1018-1025
31. Braithwaite B.D., Tomlinson M.A., Walker S.R., Davies B., Buckenham T.M., and Earnshaw J.J. Peripheral thrombolysis for acute-onset claudication. Thrombolysis Study Group. Br J Surg 86 6 (1999) 800-804
32. Ouriel K. Comparison of surgical and thrombolytic treatment of peripheral arterial disease. Rev Cardiovasc Med 3 Suppl 2 (2002) S7-S16
33. Ouriel K., and Kandarpa K. Safety of thrombolytic therapy with urokinase or recombinant tissue plasminogen activator for peripheral arterial occlusion: a comprehensive compilation of published work. J Endovasc Ther 11 4 (2004) 436-446
34. Castaneda F., Swischuk J.L., Li R., Young K., Smouse B., and Brady T. Declining-dose study of reteplase treatment for lower extremity arterial occlusions. J Vasc Interv Radiol 13 11 (2002) 1093-1098
35. Ouriel K. Endovascular techniques in the treatment of acute limb ischemia: thrombolytic agents, trials, and percutaneous mechanical thrombectomy techniques. Semin Vasc Surg 16 4 (2003) 270-279
36. Ouriel K., Shortell C.K., Azodo M.V., Guiterrez O.H., and Marder V.J. Acute peripheral arterial occlusion: predictors of success in catheter-directed thrombolytic therapy. Radiology 193 2 (1994) 561-566