Hepatic insulin resistance ties cholesterol gallstone formation and the metabolic syndrome

Annals of Hepatology

Volumn 7, Issue 3, 2008, Pages 262-264

  Kovacs, Peter ^a   Kurtz, Ulrike ^b   Wittenburg, Henning ^b  

^a UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

ABCG5 ABCG8; Cholelithiasis; Cholesterol transport; Diabetes mellitus type 2

Indexed keywords

BILE SALT; CARRIER PROTEIN; CYTOCHROME P450; CYTOCHROME P450 CYP7B1; FARNESOID X RECEPTOR; PROTEIN ABCG5; PROTEIN ABCG8; TRANSCRIPTION FACTOR FKHR;

ANIMAL MODEL; CHOLELITHIASIS; CHOLESTEROL STONE; CHOLESTEROL SYNTHESIS; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; INSULIN RESISTANCE; KNOCKOUT MOUSE; METABOLIC SYNDROME X; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NOTE; PROTEIN EXPRESSION;

EID: 50849120413     PISSN: 16652681     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1665-2681(19)31861-7     Document Type: Note

References (17)

1. Paigen B, Carey MC. Gallstones. In: King RA, Rotter JF, Motulsky AG, eds. The genetic basis of common diseases. 2nd ed. New York: Oxford University Press; 2002:298-335.
2. Misciagna G, Guerra V, Di Leo A, Correale M, Trevisan M. Insulin and gallstones: a population case control study in southern Italy. Gut 2000; 47: 144-147.
3. Ruhl CE, Everhart JE. Association of diabetes, serum insulin, and C-peptide with gallbladder disease. Hepatology 2000; 31: 299-303.
4. Méndez-Sánchez N, Bermejo-Martínez LB, Vinals Y, Chávez-Tapia NC, Vander Graff I, Ponciano-Rodríguez G, et al. Serum leptin levels and insulin resistance are associated with gallstone disease in overweight subjects. World J Gastroenterol 2005; 11: 6182-6187.
5. Nervi F, Miquel JF, Alvarez M, Ferreccio C, Garcia-Zattera MJ, Gonzalez R, et al. Gallbladder disease is associated with insulin resistance in a high risk Hispanic population. J Hepatol 2006; 45: 299-305.
6. Biddinger SB, Haas JT, Yu BB, Bezy O, Jing E, Zhang W, et al. Hepatic insulin resistance directly promotes formation of cholesterol gallstones. Nat Med 2008; 14: 778-782.
7. Michael MD, Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA, et al. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell 2000; 6: 87-97.
8. Biddinger SB, Hernandez-Ono A, Rask-Madsen C, Haas JT, Aleman JO, Suzuki R, et al. Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab 2008; 7: 125-134.
9. Kovacs P, Kress R, Rocha J, Kurtz U, Miquel JF, Nervi F, et al. Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans. J Hepatol 2008; 48: 116-124.
10. Nakae J, Kitamura T, Silver DL, Accili D. The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J Clin Invest 2001; 108: 1359-1367.
11. Wittenburg H, Lyons MA, Li R, Churchill GA, Carey MC, Paigen B. FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice. Gastroenterology 2003; 125: 868-881.
12. Wittenburg H, Lyons MA, Li R, Kurtz U, Mossner J, Churchill GA, et al. Association of a lithogenic Abcg5/Abcg8 allele on Chromosome 17 (Lith9) with cholesterol gallstone formation in PERA/EiJ mice. Mamm Genome 2005; 16: 495-504.
13. Jiang ZY, Parini P, Eggertsen G, Davis MA, Hu H, Suo GJ, et al. Increased expression of LXR alpha, ABCG5, ABCG8, and SR-BI in the liver from normolipidemic, nonobese Chinese gallstone patients. J Lipid Res 2008; 49: 464-472.
14. Buch S, Schafmayer C, Volzke H, Becker C, Franke A, von Eller-Eberstein H, et al. A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease. Nat Genet 2007; 39: 995-999.
15. Grunhage F, Acalovschi M, Tirziu S, Walier M, Wienker TF, Ciocan A, et al. Increased gallstone risk in humans conferred by common variant of hepatic ATP-binding cassette transporter for cholesterol. Hepatology 2007; 46: 793-801.
16. Bottcher Y, Tonjes A, Enigk B, Scholz GH, Bluher M, Stumvoll M, et al. A SNP haplotype of the forkhead transcription factor FOXO1A gene may have a protective effect against type 2 diabetes in German Caucasians. Diabetes Metab 2007; 33: 277-283.
17. Kuningas M, Magi R, Westendorp RG, Slagboom PE, Remm M, van Heemst D. Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age. Eur J Hum Genet 2007; 15: 294-301.