Digital microfluidic biochip design for protein crystallization

2007 IEEE/NIH Life Science Systems and Applications Workshop, LISA

Volumn , Issue , 2007, Pages 140-143

  Xu, Tao ^a   Thwar, Prasanna ^b   Srinivasan, Vijay ^b   Pamula, Vamsee K ^b   Chakrabarty, Krishnendu ^a  

^a Duke University   (United States)

^b Advanced Liquid Logic Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHIPS; DIGITAL MICROFLUIDICS; DROP FORMATION; MANUFACTURE;

BIOLOGICAL FUNCTIONS; DEGREE OF AUTOMATION; DIGITAL MICROFLUIDIC BIOCHIPS; ELECTRO-WETTING ON DIELECTRICS; MANUFACTURING COST; MICRO FLUIDIC BIOCHIPS; PROTEIN CRYSTALLIZATION; THREEDIMENSIONAL (3-D);

PROTEINS;

EID: 50849103322     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/LSSA.2007.4400904     Document Type: Conference Paper

References (20)

1. J. C. Kendrew, G. Bodo, H. M. Dintzis, R. G. Parrish, H. Wyckoff, and D. C. Phillips. "A three-dimensional model of the myoglobin molecule obtained by x-ray analysis", Nature, 181 (4610), 662-6, 1958.
2. A. McPherson, "Crystallization of macromolecules - general principles" Methods in Enzymology A, 114, 112-120, 1985.
3. N. E. Chayen, "Recent advances in methodology for the crystallization of biological macro molecules," Journal of Crystal Growth, 198/199, 649-655, 1999.
4. N. E. Chayen, P. D. Shaw Stewart, D. L. Maeder, and D. M. Blow, "An automated system for micro-batch protein crystallization and screening," Journal of Applied Crystallography, 23, 297-302, 1990.
5. J. R. Luft, D. M. Rak, G. T. DeTitta, "Microbatch macromolecular crystallization in micropipettes," Journal of Crystal Growth, 196, 450-455, 1999.
6. http://www.douglas.co.uk/oryx8.htm
7. http://www.gilson.com/Applications/proteinCrystal.asp
8. http://www.syrrx.com/technology/index.htm
9. R. C. Stevens, "High-throughput protein crystallization," Current Opinion in Structural Biology, 10, 558-563, 2000.
10. H. I. Krupka, B. Rupp, B. W. Segelke, T. P. Lekin, D. Wright, H. C. Wu, P. Todd, and A. Azarani, "The high-speed Hydra-Plus-One system for automated high-throughput protein crystallography," Acta Crystallographica, D58, 1523-1526, 2002.
11. V. Srinivasan, V. K. Pamula, and R. B. Fair, "An integrated digital microfluidic lab-on-a-chip for clinical diagnostics on human physiological fluids" Lab on a Chip, pp. 310-315, 2004.
12. T. Xu and K. Chakrabarty, "Droplet-trace-based array partitioning and a pin assignment algorithm for the automated design of digital microfluidic biochips", Proc. IEEE/ACM International Conference on Hardware/Software Codesign and System Synthesis, pp. 112-117, 2006.
13. M. G. Pollack, R. B. Fair, and A. D. Shenderov, "Electrowetting- based actuation of liquid droplets for microfluidic applications", Applied Physics Letters, vol. 77, pp. 1725-1726, 2000.
14. J. Gong and C. J. Kim, "Two-dimensional digital microfluidic system by multi-layer printed circuit board," Proc. IEEE MEMS 2005
15. A. Moreno, E. Saridakis, and N. E. Chayen, "Combination of oils and gels for enhancing the growth of protein crystals," Journal Appl Crystallogr, 35, 140-142, 2002.
16. W. Hwang, F. Su, and K. Chakrabarty, "Automated design of pin-constrained digital microfluidic arrays for lab-on-a-chip applications," Proc. IEEE/ACM Design Automation Conference, pp. 925-930, 2006
17. Connect5 strategies, www.springfrog.com/games/gomoku/
18. R. Diestel, Graph Theory, Springer, Berlin, 2005.
19. http://www.ultimatepcb.com/index.php.
20. http://www.massdesign.com.