Engineered pharmabiotics with improved therapeutic potential

Human Vaccines

Volumn 4, Issue 4, 2008, Pages 271-274

  Sleator, Roy D ^a   Hill, Colin ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Betaine; BetL; Bifidobacterium; Compatible solute; Lactobacillus; Patho biotechnology; Pharmabiotic; Probiotic; Stress

Indexed keywords

ANTIGEN; ANTIINFECTIVE AGENT; BIFIDOBACTERIUM BREVE UCC2003 EXTRACT; DRUG CARRIER; LACTOBACILLUS SALIVARIUS UCC118 EXTRACT; LISTERIA MONOCYTOGENES EXTRACT; PROBIOTIC AGENT; THYMIDINE; THYMIDYLATE SYNTHASE; THYMINE; VACCINE;

ANTIMICROBIAL ACTIVITY; BACTERIAL COLONIZATION; BACTERIAL SURVIVAL; BACTERIUM ADHERENCE; BACTERIUM CULTURE; BIFIDOBACTERIUM BREVE; BIOMEDICAL ENGINEERING; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG FORMULATION; DRUG UPTAKE; ENTERITIS; EX VIVO STUDY; GENE TARGETING; HUMAN; IN VIVO STUDY; INFECTION CONTROL; INFECTION PREVENTION; INNATE IMMUNITY; LACTOBACILLUS SALIVARIUS; LISTERIA MONOCYTOGENES; MOLECULAR CLONING; NONHUMAN; PASSIVE IMMUNIZATION; PATIENT SAFETY; REVIEW; STRESS; TRANSGENIC ORGANISM;

EID: 50849100736     PISSN: 15548600     EISSN: 15548619     Source Type: Journal    
DOI: 10.4161/hv.4.4.6315     Document Type: Review

References (26)

1. Sleator RD, Hill C. 'Bioengineered bugs' - A Patho-biotechnology approach to probiotic research and applications. Med Hypotheses 2007; 70:167-9.
2. Paton AW, Morona R, Paton JC. Designer probiotics for prevention of enteric infections. Nat Rev Microbiol 2006; 4:193-200.
3. Hill C, Cotter P, Sleator RD et al. Bacterial stress response in Listeria monocytogenes: Jumping the hurdles imposed by minimal processing. Int Dairy J 2002; 12:273-83.
4. Sleator RD, Hill C. Bacterial osmoadaptation: The role of osmolytes in bacterial stress and virulence. FEMS Microbiol Rev 2002; 26:49-71.
5. Sleator RD, Gahan CGM, Hill C. A postgenomic appraisal of osmotolerance in Listeria monocytogenes. Appl Environl Microbiol 2003; 69:1-9.
6. Sleator RD, Gahan CGM, Abee T et al. Identification and disruption of BetL, a secondary glycine betaine transport system linked to the salt tolerance of Listeria monocytogenes LO28. Appi Environl Microbiol 1999; 65:2078-83.
7. Sleator RD, Gahan CGM, O'Driscoll B et al. Analysis of the role of betL in contributing to the growth and survival of Listeria monocytogenes LO28. Int J Food Microbiol 2000; 60:261-8.
8. Sleator RD, Wood JM, Hill C. Transcriptional regulation and posttranslational activity of the betaine transporter BetL in Listeria monocytogenes is controlled by environmental salinity. J Bacteriol 2003; 185:7140-4.
9. Sheehan VM, Sleator RD, Fitzgerald GF et al. Heterologous expression of BetL, a betaine uptake system, enhances the stress tolerance of Lactobacillus salivarius UCC118. Appl Environ Microbiol 2006; 72:2170-7.
10. Claesson MJ, Li Y, Leahy S et al. Multireplicon genome architecture of Lactobacillus salivarius. Proc Natl Acad Sci USA 2006; 103:6718-23.
11. Smiddy M, Sleator RD, Patterson MF et al. Role for compatible solutes glycine betaine and L-carnitine in listerial barotolerance. Appl Environ Microbiol 2004; 70:7555-7.
12. Smiddy M, O'Gorman L, Sleator RD et al. Greater high-pressure resistance of bacteria in oysters than in broth. Inn Food Sci Emerg Tech 2005; 6:83-90.
13. Termont S, Vandenbroucke K, Iserentant D et al. Intracellular accumulation of trehalose protects Lactococcus lactis from freeze-drying damage and bile toxicity and increases gastric acid resistance. Appl Environ Microbiol 2006; 72:7694-700.
14. Sheehan V, Sleator RD, Fitzgerald G et al. Improving gastric transit, gastrointestinal persistence and therapeutic efficacy of the probiotic strain Bifidobacterium breve UCC2003. Microbiol 2007; 153:3563-71.
15. Sleator RD, Gahan CGM, Abee T et al. Analysis of the role of OpuC, an osmolyte transport system, in salt tolerance and virulence potential of Listeria monocytogenes. Appl Environ Microbiol 2001; 67:2692-8.
16. Paton AW, Morona R, Paton JC. A new biological agent for treatment of Shiga toxigenic Escherichia coli infections and dysentery in humans. Nat Med 2000; 6:265-70.
17. Paton AW, Morona R, Paton JC. Neutralization of shiga toxins Stx1, Stx2c and Stx2e by recombinant bacteria expressing mimics of globotriose and globotetraose. Infect Immun 2001; 69:1967-70.
18. Paton AW, Jennings MP, Motona R et al. Recombinant probiotics for treatment and prevention of enterotoxigenic Escherichia coli diarrhea. Gastroenterology 2005; 128:1219-28.
19. Rao S, Hu S, McHugh L et al. Toward a live microbial microbicide for HIV: Commensal bacteria secreting an HIV fusion inhibitor peptide. Proc Natl Acad Sci USA 2005; 102:11993-8.
20. Laurel AL, Berger EA. An anti-HIV microbicide comes alive Proc Natl Acad Sci USA 2005; 102:12294-5.
21. Chang TL-Y, Chang CH, Simpson DA et al. Inhibition of HIV infectivity by a natural human isolate of Lactobacillus jensenii engineered to express functional two-domain CD4. Proc Natl Acad Sci USA 2003; 100: 11672-7.
22. Guimarães VD, Gabriel JE, Lefevre F et al. Internalin-expressing Lactococcus lactis is able to invade small intestine of guinea pigs and deliver DNA into mammalian epithelial cells. Microbes Infect 2005; 7:836-44.
23. Holmgren J, Czerkinsky C. Mucosal immunity and vaccines. Nat Med 2005; 11:S45-53.
24. Torres B, Jaenecke S, Timmis KN et al. A dual lethal system to enhance containment of recombinant micro-organisms. Microbiol 2003; 149:3595-601.
25. Steidler L, Neirynck S, Huyghebaert N et al. Biological containment of genetically modified Lactococcus lactis for intestinal delivery of human interleukin 10. Nat Biotechnol 2003; 21:785-9.
26. Sleator RD, Hill C. Probiotics as therapeutics for the developing world. J Infect Develop Countries 2007; 1:7-12.