Involvement of p38 MAPK phosphorylation and nitrate formation in aristolochic acid-mediated antiplatelet activity

Planta Medica

Volumn 74, Issue 10, 2008, Pages 1240-1245

  Shen, Ming Yi ^a   Liu, Chien Liang ^b   Hsiao, Geroge ^a   Liu, Chiung Yueh ^a   Lin, Kuang Hung ^a   Chou, Duen Suey ^a   Sheu, Joen Rong ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b MACKAY MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Aristolochia fangchi; Aristolochiaceae; Aristolochic acid; Nitrate; p38 MAPK; Phospholipase C; Platelet aggregation

Indexed keywords

ARISTOLOCHIC ACID; COLLAGEN; CYCLIC GMP; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRATE; PHOSPHATIDYLINOSITIDE; THROMBOXANE A2;

ANTICOAGULATION; ARISTOLOCHIA; ARTICLE; CHINESE MEDICINE; CONTROLLED STUDY; DRUG POTENCY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PROTEIN PHOSPHORYLATION; THROMBOCYTE AGGREGATION;

ARISTOLOCHIC ACIDS; HUMANS; MAP KINASE SIGNALING SYSTEM; NITRATES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS;

ARISTOLOCHIA FANGCHI; ARISTOLOCHIACEAE;

EID: 50649118645     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1074560     Document Type: Article

References (14)

1. Vanherweghem JL, Depierreux M, Tielemans C, Abramowicz D, Dratwa M, Jadoul M et al. Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs. Lancet 1993; 341: 387-91
2. Rietjens IM, Martena MJ, Boersma MG, Spiegelenberg W, Alink GM. Molecular mechanisms of toxicity of important food-borne phytotoxins. Mol Nutr Food Res 2005; 49: 131-58
3. Schmeiser HH, Bieler CA, Wiessler M, van Ypersele de Strihou C, Cosyns JP. Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy. Cancer Res 1996; 56: 2025-8
4. Sheu JR, Lee CR, Lin CH, Hsiao G, Ko WC, Chen YC et al. Mechanisms involved in the antiplatelet activity of Staphylococcus aureus lipoteichoic acid in human platelets. Thromb Haemost 2000; 72: 617-21
5. 2: its effect on enzymatic and pathological activities. Toxicon 1987; 25: 929-37
6. Wu TS, Ou LF, Teng CM. Aristolochic acids, aristolactam alkaloids and amides from Aristolochia kankauensis. Phytochemistry 1994; 36: 1063-8
7. Sheu JR, Lin CH, Peng CH, Huang TF. Triflavin, an Arg-Gly-Asp-containing peptide, inhibits the adhesion of tumor cells to matrix protein via binding to multiple integrin receptors expressed on human hepatoma cells. Proc Soc Exp Biol Med 1996; 213: 71-9
8. +2 indicator with greatly improved fluorescence properties. J Biol Chem 1985; 260: 3440-50
9. Li Z, Ajdic J, Eigenthaler M, Du X. A predominant role for cAMP-dependent protein kinase in the cGMP-induced phosphorylation of vasodilator-stimulated phosphoprotein and platelet inhibition in humans. Blood 2003; 101: 4423-9
10. Zhao Y, Brandish PE, DiValentin M, Schelvis JP, Babcock GT, Marletta MA. Inhibition of soluble guanylate cyclase by ODQ. Biochemistry 2000; 39: 10848-54
11. Mangin P, Yuan Y, Goncalves I, Eckly A, Freund M, Cazenave JP et al. Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA. J Biol Chem 2003; 278: 32880-91
12. McDonald LJ, Murad F. Nitric oxide and cyclic GMP signaling. Proc Soc Exp Biol Med 1996; 211: 1-6
13. Bugaud F, Nadal-Wollbold F, Levy-Toledano S, Rosa JP, Bryckaert M. Regulation of c-jun-NH2 terminal kinase and extracellular-signal regulated kinase in human platelets. Blood 1999; 94: 3800-5
14. 2 cascade in hydroperoxide-stressed platelets. Free Radic Biol Med 2003; 35: 616-25