Gene translocations in musculoskeletal neoplasms

Clinical Orthopaedics and Related Research

Volumn 466, Issue 9, 2008, Pages 2131-2146

  Krishnan, Balaji ^a   Khanna, Gaurav ^a   Clohisy, Denis ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; ONCOPROTEIN; RNA BINDING PROTEIN; RNA BINDING PROTEIN EWS; TLS CHOP FUSION PROTEIN, HUMAN; TLS-CHOP FUSION PROTEIN, HUMAN;

ALVEOLAR SOFT PART SARCOMA; AMELOBLASTOMA; ANEURYSMAL BONE CYST; BONE TUMOR; CHONDROMATOSIS; CHONDROSARCOMA; CHORDOMA; CHROMOSOME ABERRATION; CLEAR CELL SARCOMA; CLINICAL DECISION MAKING; CONFERENCE PAPER; DERMATOFIBROSARCOMA PROTUBERANS; DESMOID TUMOR; DIAGNOSTIC ACCURACY; DNA MICROARRAY; EWING SARCOMA; FIBROELASTOMA; FIBROSARCOMA; FLUORESCENCE IN SITU HYBRIDIZATION; FUSION GENE; GENE TRANSLOCATION; GIANT CELL TUMOR; HISTOPATHOLOGY; HUMAN; LIPOBLASTOMA; LIPOMA; MESENCHYMOMA; MOLECULAR GENETICS; MYXOSARCOMA; OSTEOCHONDROMA; OSTEOSARCOMA; PHARMACOGENETICS; PREDICTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHABDOMYOSARCOMA; SOFT TISSUE TUMOR; SYNOVIAL SARCOMA; TISSUE SECTION; ALGORITHM; GENETICS; IMMUNOCHEMISTRY; KARYOTYPING; MUSCLE TUMOR; PATHOLOGY; PROGNOSIS; REVIEW; SARCOMA; SIGNAL TRANSDUCTION;

ALGORITHMS; BONE NEOPLASMS; HUMANS; IMMUNOCHEMISTRY; KARYOTYPING; MUSCLE NEOPLASMS; ONCOGENE PROTEINS, FUSION; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA-BINDING PROTEIN EWS; RNA-BINDING PROTEIN FUS; SARCOMA; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP; TRANSLOCATION, GENETIC;

EID: 50649108991     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1007/s11999-008-0342-0     Document Type: Conference Paper

References (110)

1. SV Allander PB Illei Y Chen CR Antonescu M Bittner M Ladanyi PS Meltzer 2002 Expression profiling of synovial sarcoma by cDNA microarrays: association of ERBB2, IGFBP2, and ELF3 with epithelial differentiation Am J Pathol 161 1587 1595
2. G Ambrosini EB Sambol D Carvajal LT Vassilev S Singer GK Schwartz 2007 Mouse double minute antagonist nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1 Oncogene 26 3473 3481
3. J Anderson T Gordon A McManus T Mapp S Gould A Kelsey H McDowell R Pinkerton J Shipley K Pritchard-Jones UK Children's Cancer Study Group (UKCCSG) and the UK Cancer Cytogenetics Group 2001 Detection of the PAX3-FKHR fusion gene in paediatric rhabdomyosarcoma: a reproducible predictor of outcome? Br J Cancer 85 831 835
4. J Anderson A Ramsay S Gould K Pritchard-Jones 2001 PAX3-FKHR induces morphological change and enhances cellular proliferation and invasion in rhabdomyosarcoma Am J Pathol 159 1089 1096
5. CR Antonescu 2006 The role of genetic testing in soft tissue sarcoma Histopathology 48 13 21
6. CR Antonescu A Elahi M Humphrey MY Lui JH Healey MF Brennan JM Woodruff SC Jhanwar M Ladanyi 2000 Specificity of TLS-CHOP rearrangement for classic myxoid/round cell liposarcoma: absence in predominantly myxoid well-differentiated liposarcomas J Mol Diagn 2 132 138
7. P Argani M Fritsch SS Kadkol A Schuster JB Beckwith EJ Perlman 2000 Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic nephroma in paraffin-embedded tissue: application to challenging pediatric renal stromal tumors Mod Pathol 13 29 36
8. UH Athale SA Shurtleff JJ Jenkins CA Poquette M Tan JR Downing AS Pappo 2001 Use of reverse transcriptase polymerase chain reaction for diagnosis and staging of alveolar rhabdomyosarcoma, Ewing sarcoma family of tumors, and desmoplastic small round cell tumor J Pediatr Hematol Oncol 23 99 104
9. J Atiye M Wolf S Kaur O Monni T Bohling A Kivioja E Tas M Serra M Tarkkanen S Knuutila 2005 Gene amplifications in osteosarcoma-CGH microarray analysis Genes Chromosomes Cancer 42 158 163
10. K Baird S Davis CR Antonescu UL Harper RL Walker Y Chen AA Glatfelter PH Duray PS Meltzer 2005 Gene expression profiling of human sarcomas: insights into sarcoma biology Cancer Res 65 9226 9235
11. F Ballaux M Debiec-Rychter I De Wever R Sciot 2004 Chondroid lipoma is characterized by t(11;16)(q13;p12-13) Virchows Arch 444 208 210
12. FG Barr RB Womer 2007 Molecular diagnosis of Ewing family tumors: too many fusions...? J Mol Diagn 9 437 440
13. J Bayani JA Squire 2001 Advances in the detection of chromosomal aberrations using spectral karyotyping Clin Genet 59 65 73
14. B Bode-Lesniewska S Frigerio U Exner MT Abdou H Moch Zimmermann 2007 Relevance of translocation type in myxoid liposarcoma and identification of a novel EWSR1-DDIT3 fusion Genes Chromosomes Cancer 46 961 971
15. JV Bovee LJ van den Broek AM Cleton-Jansen PC Hogendoorn 2000 Up-regulation of PTHrP and bcl-2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma Lab Invest 80 1925 1934
16. JA Bridge M Nelson C Orndal P Bhatia JR Neff 1998 Clonal karyotypic abnormalities of the hereditary multiple exostoses chromosomal loci 8q24.1 (EXT1) and 11p11-12 (EXT2) in patients with sporadic and hereditary osteochondromas Cancer 82 1657 1663
17. MG Butler GA Dahir LK Hedges SF Juliao MF Sciadini HS Schwartz 1995 Cytogenetic, telomere, and telomerase studies in five surgically managed lumbosacral chordomas Cancer Genet Cytogenet 85 51 57
18. CC Chang VB Shidham 2003 Molecular genetics of pediatric soft tissue tumors: clinical application J Mol Diagn 5 143 154
19. P Dal Cin P Kools R Sciot I De Wever B Van Damme W Van de Ven H Van den Berghe 1993 Cytogenetic and fluorescence in situ hybridization investigation of ring chromosomes characterizing a specific pathologic subgroup of adipose tissue tumors Cancer Genet Cytogenet 68 85 90
20. P Dal Cin R Sciot P Polito M Stas I de Wever A Cornelis H Van den Berghe 1997 Lesions of 13q may occur independently of deletion of 16q in spindle cell/pleomorphic lipomas Histopathology 31 222 225
21. P Dal Cin R Sciot F Speleman I Samson G Laureys C de Potter F Meire B van Damme H van den Berghe 1994 Chromosome aberrations in fibrous dysplasia Cancer Genet Cytogenet 77 114 117
22. E Davicioni FG Finckenstein V Shahbazian JD Buckley TJ Triche MJ Anderson 2006 Identification of a PAX-FKHR gene expression signature that defines molecular classes and determines the prognosis of alveolar rhabdomyosarcomas Cancer Res 66 6936 6946
23. E de Alava A Kawai JH Healey I Fligman PA Meyers AG Huvos WL Gerald SC Jhanwar P Argani CR Antonescu FJ Pardo-Mindan J Ginsberg R Womer ER Lawlor J Wunder I Andrulis PH Sorensen FG Barr M Ladanyi 1998 EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma J Clin Oncol 16 1248 1255
24. E de Alava A Panizo CR Antonescu AG Huvos FJ Pardo-Mindan FG Barr M Ladanyi 2000 Association of EWS-FLI1 type 1 fusion with lower proliferative rate in Ewing's sarcoma Am J Pathol 156 849 855
25. HR Dhaini DG Thomas TJ Giordano TD Johnson JS Biermann K Leu PF Hollenberg LH Baker 2003 Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma J Clin Oncol 21 2481 2485
26. CH Evans SC Ghivizzani JH Herndon PD Robbins 2005 Gene therapy for the treatment of musculoskeletal diseases J Am Acad Orthop Surg 13 230 242
27. CH Evans SC Ghivizzani PD Robbins 2000 The 2003 Nicolas Andry Award. Orthopaedic gene therapy Clin Orthop Relat Res 429 316 329
28. CD Fletcher M Akerman P Dal Cin I de Wever N Mandahl F Mertens F Mitelman J Rosai A Rydholm R Sciot G Tallini H van den Berghe W van de Ven R Vanni H Willen 1996 Correlation between clinicopathological features and karyotype in lipomatous tumors. A report of 178 cases from the chromosomes and morphology (CHAMP) collaborative study group Am J Pathol 148 623 630
29. N Galili RJ Davis WJ Fredericks S Mukhopadhyay FJ Rauscher 3rd BS Emanuel G Rovera FG Barr 1993 Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma Nat Genet 5 230 235
30. G Gasparini R Longo M Fanelli BA Teicher 2005 Combination of antiangiogenic therapy with other anticancer therapies: results, challenges, and open questions J Clin Oncol 23 1295 1311
31. D Gisselsson MK Hibbard P Dal Cin R Sciot BL Hsi HP Kozakewich JA Fletcher 2001 PLAG1 alterations in lipoblastoma: involvement in varied mesenchymal cell types and evidence for alternative oncogenic mechanisms Am J Pathol 159 955 962
32. D Gisselsson M Hoglund F Mertens P Dal Cin N Mandahl 1999 Hibernomas are characterized by homozygous deletions in the multiple endocrine neoplasia type I region. Metaphase fluorescence in situ hybridization reveals complex rearrangements not detected by conventional cytogenetics Am J Pathol 155 61 66
33. JF van Graadt Roggen JV Bovee J Morreau PC Hogendoorn 1999 Diagnostic and prognostic implications of the unfolding molecular biology of bone and soft tissue tumours J Clin Pathol 52 481 489
34. L Grazioli L Olivetti C Fugazzola A Benetti C Stanga E Dettori C Gallo L Matricardi A Giacobbe A Chiesa 1999 The pseudocapsule in hepatocellular carcinoma: correlation between dynamic MR imaging and pathology Eur Radiol 9 62 67
35. F Grosso RL Jones GD Demetri IR Judson JY Blay A Le Cesne R Sanfilippo P Casieri P Collini P Dileo C Spreafico S Stacchiotti E Tamborini JC Tercero J Jimeno M D'Incalci A Gronchi JA Fletcher S Pilotti PG Casali 2007 Efficacy of trabectedin (ecteinascidin-743) in advanced pretreated myxoid liposarcomas: a retrospective study Lancet Oncol 8 595 602
36. L Guillou J Benhattar F Bonichon G Gallagher P Terrier E Stauffer S Somerhausen Nde JJ Michels G Jundt DR Vince S Taylor M Genevay F Collin M Trassard JM Coindre 2004 Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: a multicenter, retrospective analysis J Clin Oncol 22 4040 4050
37. Y Guo X Zi Z Koontz A Kim J Xie R Gorlick RF Holcombe BH Hoang 2007 Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma saos-2 cells J Orthop Res 25 964 971
38. Y Hattori Y Maitani 2005 Folate-linked lipid-based nanoparticle for targeted gene delivery Curr Drug Deliv 2 243 252
39. E Hauben LC van den Broek E Van Marck PC Hogendoorn 2001 Adamantinoma-like Ewing's sarcoma and Ewing's-like adamantinoma. The t(11; 22), t(21; 22) status J Pathol 195 218 221
40. HM Hazelbag JW Wessels P Mollevangers E van den Berg WM Molenaar PC Hogendoorn 1997 Cytogenetic analysis of adamantinoma of long bones: further indications for a common histogenesis with osteofibrous dysplasia Cancer Genet Cytogenet 97 5 11
41. DA Hill MJ O'Sullivan X Zhu RT Vollmer PA Humphrey LP Dehner JD Pfeifer 2002 Practical application of molecular genetic testing as an aid to the surgical pathologic diagnosis of sarcomas: a prospective study Am J Surg Pathol 26 965 977
42. S Hopyan N Gokgoz R Poon RC Gensure C Yu WG Cole RS Bell H Juppner IL Andrulis JS Wunder BA Alman 2002 A mutant PTH/PTHrP type I receptor in enchondromatosis Nat Genet 30 306 310
43. N Horie H Murata Y Nishigaki T Matsui H Segawa M Nogawa T Yuasa S Kimura T Maekawa S Fushiki T Kubo 2006 The third-generation bisphosphonates inhibit proliferation of murine osteosarcoma cells with induction of apoptosis Cancer Lett 238 111 118
44. S Hu-Lieskovan JD Heidel DW Bartlett ME Davis TJ Triche 2005 Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma Cancer Res 65 8984 8992
45. H Inagaki T Nagasaka T Otsuka E Sugiura N Nakashima T Eimoto 2000 Association of SYT-SSX fusion types with proliferative activity and prognosis in synovial sarcoma Mod Pathol 13 482 488
46. T Ito M Ouchida Y Morimoto A Yoshida Y Jitsumori T Ozaki H Sonobe H Inoue K Shimizu 2005 Significant growth suppression of synovial sarcomas by the histone deacetylase inhibitor FK228 in vitro and in vivo Cancer Lett 224 311 319
47. A Ivkovic A Pascher D Hudetz M Jelic M Haspl R Windhager M Pecina 2006 Current concepts in gene therapy of the musculoskeletal system Acta Chir Orthop Traumatol Cech 73 115 122
48. DH Jones T Nakashima OH Sanchez I Kozieradzki SV Komarova I Sarosi S Morony E Rubin R Sarao CV Hojilla V Komnenovic YY Kong M Schreiber SJ Dixon SM Sims R Khokha T Wada JM Penninger 2006 Regulation of cancer cell migration and bone metastasis by RANKL Nature 440 692 696
49. A Kawai J Woodruff JH Healey MF Brennan CR Antonescu M Ladanyi 1998 SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma N Engl J Med 338 153 160
50. KM Kelly RB Womer FG Barr 1998 PAX3-FKHR and PAX7-FKHR gene fusions in rhabdomyosarcoma J Pediatr Hematol Oncol 20 517 518
51. D Kerob F Pedeutour C Leboeuf O Verola E de Kerviler JM Servant F Sarandi G Bousquet I Madelaine-Chambrin C Pruvost F Calvo A Janin C Lebbe 2008 Value of cytogenetic analysis in the treatment of dermatofibrosarcoma protuberans J Clin Oncol 26 1757 1759
52. SE Kilpatrick J Doyon PF Choong FH Sim AG Nascimento 1996 The clinicopathologic spectrum of myxoid and round cell liposarcoma. A study of 95 cases Cancer 77 1450 1458
53. AS Kiselyov 2006 Targeting the hedgehog signaling pathway with small molecules Anticancer Agents Med Chem 6 445 449
54. SR Knezevich DE McFadden W Tao JF Lim PH Sorensen 1998 A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma Nat Genet 18 184 187
55. Y Kong R Poon P Nadesan T Di Muccio R Fodde R Khokha BA Alman 2004 Matrix metalloproteinase activity modulates tumor size, cell motility, and cell invasiveness in murine aggressive fibromatosis Cancer Res 64 5795 5803
56. M Ladanyi CR Antonescu DH Leung JM Woodruff A Kawai JH Healey MF Brennan JA Bridge JR Neff FG Barr JD Goldsmith JS Brooks JR Goldblum SZ Ali J Shipley CS Cooper C Fisher B Skytting O Larsson 2002 Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients Cancer Res 62 135 140
57. M Ladanyi W Gerald 1994 Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor Cancer Res 54 2837 2840
58. M Ladanyi MY Lui CR Antonescu A Krause-Boehm A Meindl P Argani JH Healey T Ueda H Yoshikawa A Meloni-Ehrig PH Sorensen F Mertens N Mandahl H van den Berghe R Sciot PD Cin J Bridge 2001 The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25 Oncogene 20 48 57
59. AJ Lazar JC Trent D Lev 2007 Sarcoma molecular testing: diagnosis and prognosis Curr Oncol Rep 9 309 315
60. H Lugo-Vicente 2000 Molecular biology and genetics affecting pediatric solid tumors Bol Asoc Med P R 92 72 82
61. Z Ma DA Hill MH Collins SW Morris J Sumegi M Zhou C Zuppan JA Bridge 2003 Fusion of ALK to the ran-binding protein 2 (RANBP2) gene in inflammatory myofibroblastic tumor Genes Chromosomes Cancer 37 98 105
62. RG Maki 2001 Soft tissue sarcoma as a model disease to examine cancer immunotherapy Curr Opin Oncol 13 270 274
63. N Mandahl M Hoglund F Mertens A Rydholm H Willen O Brosjo F Mitelman 1994 Cytogenetic aberrations in 188 benign and borderline adipose tissue tumors Genes Chromosomes Cancer 9 207 215
64. F Mertens CD Fletcher CR Antonescu JM Coindre M Colecchia HA Domanski E Downs-Kelly C Fisher JR Goldblum L Guillou R Reid J Rosai R Sciot N Mandahl I Panagopoulos 2005 Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene Lab Invest 85 408 415
65. A Mezzelani L Mariani E Tamborini V Agus C Riva S Lo Vullo A Fabbri M Stumbo A Azzarelli PG Casali A Gronchi G Sozzi MA Pierotti S Pilotti 2001 SYT-SSX fusion genes and prognosis in synovial sarcoma Br J Cancer 85 1535 1539
66. F Micci MR Teixeira B Bjerkehagen S Heim 2002 Characterization of supernumerary rings and giant marker chromosomes in well-differentiated lipomatous tumors by a combination of G-banding, CGH, M-FISH, and chromosome- and locus-specific FISH Cytogenet Genome Res 97 13 19
67. M Miettinen 2006 From morphological to molecular diagnosis of soft tissue tumors Adv Exp Med Biol 587 99 113
68. Mitelman Database of Chromosome Aberrations in Cancer (2007). Mitelman F, Johansson B, Mertens F, eds. Available at: http://cgap.nci.nih.gov/Chromosomes/ Mitelman. Accessed August 15, 2007.
69. JA Morcuende JA Buckwalter 1997 New advances in the molecular biology of musculoskeletal neoplasms Iowa Orthop J 17 115 120
70. CA Muro-Cacho 1998 The role of immunohistochemistry in the diagnosis of primary tumors of the bone Cancer Control 5 561 569
71. S Nagayama C Fukukawa T Katagiri T Okamoto T Aoyama N Oyaizu M Imamura J Toguchida Y Nakamura 2005 Therapeutic potential of antibodies against FZD 10, a cell-surface protein, for synovial sarcomas Oncogene 24 6201 6212
72. S Naumann PA Krallman KK Unni ME Fidler JR Neff JA Bridge 2002 Translocation der(13;21)(q10;q10) in skeletal and extraskeletal mesenchymal chondrosarcoma Mod Pathol 15 572 576
73. G Nilsson B Skytting Y Xie B Brodin R Perfekt N Mandahl J Lundeberg M Uhlen O Larsson 1999 The SYT-SSX1 variant of synovial sarcoma is associated with a high rate of tumor cell proliferation and poor clinical outcome Cancer Res 59 3180 3184
74. M Nilsson M Hoglund I Panagopoulos R Sciot P Dal Cin M Debiec-Rychter F Mertens N Mandahl 2002 Molecular cytogenetic mapping of recurrent chromosomal breakpoints in tenosynovial giant cell tumors Virchows Arch 441 475 480
75. AM Oliveira CD Fletcher 2004 Molecular prognostication for soft tissue sarcomas: are we ready yet? J Clin Oncol 22 4031 4034
76. I Panagopoulos F Mertens M Isaksson J Limon P Gustafson B Skytting M Akerman R Sciot P Dal Cin I Samson M Iliszko J Ryoe M Debiec-Rychter A Szadowska O Brosjo O Larsson A Rydholm N Mandahl 2001 Clinical impact of molecular and cytogenetic findings in synovial sarcoma Genes Chromosomes Cancer 31 362 372
77. I Panagopoulos CT Storlazzi CD Fletcher JA Fletcher A Nascimento HA Domanski J Wejde O Brosjo A Rydholm M Isaksson N Mandahl F Mertens 2004 The chimeric FUS/CREB3l2 gene is specific for low-grade fibromyxoid sarcoma Genes Chromosomes Cancer 40 218 228
78. M Partinen K Hirvonen C Hublin M Halavaara H Hiltunen 2003 Effects of after-midnight intake of zolpidem and temazepam on driving ability in women with non-organic insomnia Sleep Med 4 553 561
79. M Peter J Couturier H Pacquement J Michon G Thomas H Magdelenat O Delattre 1997 A new member of the ETS family fused to EWS in Ewing tumors Oncogene 14 1159 1164
80. H Qi P Dal Cin JM Hernandez JL Garcia R Sciot C Fletcher P Van Eyken I De Wever H Van den Berghe 1996 Trisomies 8 and 20 in desmoid tumors Cancer Genet Cytogenet 92 147 149
81. SJ Qualman RA Morotti 2002 Risk assignment in pediatric soft-tissue sarcomas: an evolving molecular classification Curr Oncol Rep 4 123 130
82. TH Rabbitts 1994 Chromosomal translocations in human cancer Nature 372 143 149
83. BD Ragland WC Bell RR Lopez GP Siegal 2002 Cytogenetics and molecular biology of osteosarcoma Lab Invest 82 365 373
84. A Rydholm 1996 Chromosomal aberrations in musculoskeletal tumours: clinical importance J Bone Joint Surg Br 78 501 506
85. R Sakimura K Tanaka F Nakatani T Matsunobu X Li M Hanada T Okada T Nakamura Y Matsumoto Y Iwamoto 2005 Antitumor effects of histone deacetylase inhibitor on Ewing's family tumors Int J Cancer 116 784 792
86. R Sakimura K Tanaka S Yamamoto T Matsunobu X Li M Hanada T Okada T Nakamura Y Li Y Iwamoto 2007 The effects of histone deacetylase inhibitors on the induction of differentiation in chondrosarcoma cells Clin Cancer Res 13 275 282
87. AA Sandberg JA Bridge 2001 Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: clear cell sarcoma (malignant melanoma of soft parts) Cancer Genet Cytogenet 130 1 7
88. AA Sandberg JA Bridge 2003 Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: chondrosarcoma and other cartilaginous neoplasms Cancer Genet Cytogenet 143 1 31
89. FA Scappaticci N Marina 2001 New molecular targets and biological therapies in sarcomas Cancer Treat Rev 27 317 326
90. GK Schwartz MA Shah 2005 Targeting the cell cycle: a new approach to cancer therapy J Clin Oncol 23 9408 9421
91. R Sciot H Dorfman P Brys P Dal Cin I De Wever CD Fletcher K Jonson N Mandahl F Mertens F Mitelman J Rosai A Rydholm I Samson G Tallini H Van den Berghe R Vanni H Willen 2000 Cytogenetic-morphologic correlations in aneurysmal bone cyst, giant cell tumor of bone and combined lesions. A report from the CHAMP study group Mod Pathol 13 1206 1210
92. MP Simon F Pedeutour N Sirvent J Grosgeorge F Minoletti JM Coindre MJ Terrier-Lacombe N Mandahl RD Craver N Blin G Sozzi C Turc-Carel KP O'Brien D Kedra I Fransson C Guilbaud JP Dumanski 1997 Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma Nat Genet 15 95 98
93. S Singer ND Socci G Ambrosini E Sambol P Decarolis Y Wu R O'Connor R Maki A Viale C Sander GK Schwartz CR Antonescu 2007 Gene expression profiling of liposarcoma identifies distinct biological types/subtypes and potential therapeutic targets in well-differentiated and dedifferentiated liposarcoma Cancer Res 67 6626 6636
94. H Sjogren J Meis-Kindblom LG Kindblom P Aman G Stenman 1999 Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma Cancer Res 59 5064 5067
95. H Sjogren JM Meis-Kindblom C Orndal P Bergh K Ptaszynski P Aman LG Kindblom G Stenman 2003 Studies on the molecular pathogenesis of extraskeletal myxoid chondrosarcoma-cytogenetic, molecular genetic, and cDNA microarray analyses Am J Pathol 162 781 792
96. B Skytting G Nilsson B Brodin Y Xie J Lundeberg M Uhlen O Larsson 1999 A novel fusion gene, SYT-SSX4, in synovial sarcoma J Natl Cancer Inst 91 974 975
97. J Sonnemann L Dreyer M Hartwig CD Palani TT Hong le U Klier B Broker U Volker JF Beck 2007 Histone deacetylase inhibitors induce cell death and enhance the apoptosis-inducing activity of TRAIL in Ewing's sarcoma cells J Cancer Res Clin Oncol 133 847 858
98. PH Sorensen JC Lynch SJ Qualman R Tirabosco JF Lim HM Maurer JA Bridge WM Crist TJ Triche FG Barr 2002 PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group J Clin Oncol 20 2672 2679
99. Sugarbaker PH, Malawer MM. Musculoskeletal Surgery for Cancer: Principles, Techniques. New York, NY: Thieme Medical Publishers; 1992, p. 4.
100. WR Sukov JC Cheville AW Carlson BM Shearer EJ Piatigorsky KL Grogg TJ Sebo JP Sinnwell RP Ketterling 2007 Utility of ALK-1 protein expression and ALK rearrangements in distinguishing inflammatory myofibroblastic tumor from malignant spindle cell lesions of the urinary bladder Mod Pathol 20 592 603
101. G Tallini M Akerman P Dal Cin I De Wever CD Fletcher N Mandahl F Mertens F Mitelman J Rosai A Rydholm R Sciot H Van den Berghe W Van den Ven R Vanni H Willen 1996 Combined morphologic and karyotypic study of 28 myxoid liposarcomas. Implications for a revised morphologic typing, (a report from the CHAMP group) Am J Surg Pathol 20 1047 1055
102. TD Tiet S Hopyan P Nadesan N Gokgoz R Poon AC Lin T Yan IL Andrulis BA Alman JS Wunder 2006 Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation Am J Pathol 168 321 330
103. TJ Triche D Schofield J Buckley 2001 DNA microarrays in pediatric cancer Cancer J 7 2 15
104. BL Waters I Panagopoulos EF Allen 2000 Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11 Cancer Genet Cytogenet 121 109 116
105. F Willeke R Ridder G Mechtersheimer M Schwarzbach A Duwe J Weitz T Lehnert C Herfarth M von Knebel Doeberitz 1998 Analysis of FUS-CHOP fusion transcripts in different types of soft tissue liposarcoma and their diagnostic implications Clin Cancer Res 4 1779 1784
106. BS Worley LT van den Broeke TJ Goletz CD Pendleton EM Daschbach EK Thomas FM Marincola LJ Helman JA Berzofsky 2001 Antigenicity of fusion proteins from sarcoma-associated chromosomal translocations Cancer Res 61 6868 6875
107. C Wu Q Wei V Utomo P Nadesan H Whetstone R Kandel JS Wunder BA Alman 2007 Side population cells isolated from mesenchymal neoplasms have tumor initiating potential Cancer Res 67 8216 8222
108. SJ Xia FG Barr 2005 Chromosome translocations in sarcomas and the emergence of oncogenic transcription factors Eur J Cancer 41 2513 2527
109. A Zoubek R Ladenstein R Windhager G Amann G Fischmeister L Kager D Jugovic PF Ambros H Gadner H Kovar 1998 Predictive potential of testing for bone marrow involvement in Ewing tumor patients by RT-PCR: a preliminary evaluation Int J Cancer 79 56 60
110. J Zucman O Delattre C Desmaze AL Epstein G Stenman F Speleman CD Fletchers A Aurias G Thomas 1993 EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts Nat Genet 4 341 345