Novel process for the synthesis of class I antiarrhythmic agent (±)-cibenzoline and its analogs

Synthetic Communications

Volumn 38, Issue 17, 2008, Pages 2967-2982

  Gholap, Atul R ^a   Paul, Vincent ^a   Srinivasan, Kumar V ^a  

^a NATIONAL CHEMICAL LABORATORY   (India)

Author keywords

Benzophenone; Cibenzoline; Cyclopropanation; Diaryl cyanoolefin

Indexed keywords

2 (2,2 BIS(4 CHLOROPHENYL)CYCLOPROPYL) 1H IMIDAZOLE; 2 (2,2 BIS(4 CHLOROPHENYL)CYCLOPROPYL) 4,5 DIHYDRO 1H IMIDAZOLE; 2 (2,2 BIS(4 FLUOROPHENYL)CYCLOPROPYL) 1H IMIDAZOLE; 2 (2,2 BIS(4 FLUOROPHENYL)CYCLOPROPYL) 4,5 DIHYDRO 1H IMIDAZOLE; 2 (9 HYDROXY 9H FLUOREN 9 YL)ACETONITRILE; 2 (9H FLUOREN 9 YLIDENE)ACETONITRILE; 2 (SPIRO(CYCLOPROPANE 1,9' FLURENE) 2 YL) 1H IMIDAZOLE; 2 (SPIRO(CYCLOPROPANE 1,9' FLURENE) 2 YL) 4,5 DIHYDRO 1H IMIDAZOLE; 2,2 BIS(4 CHLOROPHENYL)CYCLOPROPANECARBONITRILE; 2,2 BIS(4 FLUOROPHENYL)CYCLOPROPANECARBONITRILE; 2,2 DIPHENYLCYCLOPROPANECARBONITRILE; 3 HYDROXY 3,3 DIPHENYLPROPANENITRILE; 3,3 BIS(4 CHLOROPHENYL) 2 CYANOACRYLATE; 3,3 BIS(4 CHLOROPHENYL) 3 HYDROXYPROPANENITRILE; 3,3 BIS(4 CHLOROPHENYL)ACRYLONITRILE; 3,3 BIS(4 FLUOROPHENYL) 3 HYDROXYPROPANENITRILE; 3,3 BIS(4 FLUOROPHENYL)ACRYLONITRILE; 3,3 DIPHENYLACRYLONITRILE; 4,5 DEHYDROCIBENZOLINE; 4,5 DIHYDRO 2 (2,2 DIPHENYLCYCLOPROPYL) 1H IMIDAZOLE; ACRYLIC ACID DERIVATIVE; ANTIARRHYTHMIC AGENT; CIBENZOLINE; ETHYL 2 CYANO 3,3 BIS(4 FLUOROPHENYL)ACRYLATE; ETHYL 2 CYANO 3,3 DIPHENYL ACRYLATE; EXACOR; IMIDAZOLE DERIVATIVE; NITRILE; SPIRO(CYCLOPROPANE 1,9' FLUORENE) 2 CARBONITRILE; UNCLASSIFIED DRUG;

ANTIARRHYTHMIC ACTIVITY; ARTICLE; CYCLOPROPANATION; DRUG STRUCTURE; DRUG SYNTHESIS; KNOEVENAGEL CONDENSATION;

EID: 50649083673     PISSN: 00397911     EISSN: 15322432     Source Type: Journal    
DOI: 10.1080/00397910802006388     Document Type: Article

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