Lidocaine suppresses subthreshold oscillations by inhibiting persistent Na+ current in injured dorsal root ganglion neurons

Physiological Research

Volumn 57, Issue 4, 2008, Pages 639-645

  Dong, H ^a   Fan, Y H ^a   Wang, Y Y ^a   Wang, W T ^a   Hu, S J ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Dorsal root ganglion; Ectopic discharges; Lidocaine; Neuropathic pain; Persistent Na+ current; Subthreshold membrane potential oscillations

Indexed keywords

LIDOCAINE; LOCAL ANESTHETIC AGENT; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; TETRODOTOXIN;

ANIMAL; ARTICLE; CELL MEMBRANE POTENTIAL; CYTOLOGY; DRUG EFFECT; ELECTROPHYSIOLOGY; FEMALE; IN VITRO STUDY; MALE; METABOLISM; NERVE CELL; PATCH CLAMP; RAT; SPINAL GANGLION; SPRAGUE DAWLEY RAT; STATISTICAL ANALYSIS;

ANESTHETICS, LOCAL; ANIMALS; DATA INTERPRETATION, STATISTICAL; ELECTROPHYSIOLOGY; FEMALE; GANGLIA, SPINAL; LIDOCAINE; MALE; MEMBRANE POTENTIALS; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TETRODOTOXIN;

EID: 50549102953     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. AGRAWAL N, HAMAM BN, MAGISTRTTI J, ALONSO A, RAGSDALD DS: Persistent sodium channel activity mediates subthreshold membrane potential oscillations and low-threshold spikes in rat entorhinal cortex layer V neurons. Neuroscience 102: 53-64, 2001.
2. AMIR R, LIU CN, KOCSIS JD, DEVOR M: Oscillatory mechanism in primary sensory neurons. Brain 125: 421-435, 2002.
3. AMIR R, MICHAELIS M, DEVOR M: Membrane potential oscillations in dorsal root ganglion neurons: role in normal electrogenesis and neuropathic pain. J Neurosci 19: 8589-8596, 1999.
4. BATH FW, JENSEN TS, KASTRUP J, STIGSBY B, DEJGARD A: The effect of intravenous lidocaine on nociceptive processing in diabetic neuropathy. Pain 40: 29-34, 1990.
5. BOAS RA, COVINO BG, SHAHNARIAN A: Analgesic responses to i.v. lidocaine. Br J Anesth 54: 501-505, 1982.
6. + current in mammalian central neurons. Annu Rev Physiol 58: 349-362, 1996.
7. DEVOR M, WALL PD, CATALAN N: Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction. Pain 48: 261-268, 1992.
8. DEVOR M, SELTZER Z: Pathophysiology of damaged nerves in relation to chronic pain. In: Textbook of Pain, PD WALL, R MELZACK (eds), Churchill Livingston Press, London, 1999, pp 129-164.
9. GRACELY RH, LYNCH SA, BENNETT GJ: Painful neuropathy: altered central processing maintained dynamically by peripheral input. Pain 51: 175-194, 1992.
10. HAN HC, LEE DH, CHUNG JM: Characteristics of ectopic discharge in a rat neuropathic pain model. Pain 84: 253-261, 2000.
11. + current in rat hippocampal pyramidal cells. J Physiol 545: 783-805, 2002.
12. HU SJ, CHEN LM, LIU K: Membrane potential oscillations produce burst discharges in neurons of the rat dorsal root ganglion. Chin J Neurosci 4: 21-25, 1997.
13. HU SJ, XING JL: An experimental model for chronic compression of dorsal root ganglion produced by intervertebral foramen stenosis in the rat. Pain 77: 15-23, 1998.
14. HUTCHEON B, YAROM Y: Resonance, oscillation and the intrinsic frequency preferences of neurons. Trends Neurosci 23: 216-222, 2000.
15. KASTRUP J, PETERSEN P, DEJGARD A, ANGELO HR, HILSTED J: Intravenous lidocaine infusion-a new treatment of chronic painful diabetic neuropathy. Pain 28: 69-75, 1987.
16. KLINK R, ALONSO A: Ionic mechanisms for the subthreshold oscillations and differential electroresponsiveness of medial entorhinal cortex layer II neurons. J Neurophysiol 70: 144-157, 1993.
17. LAI J, HUNTER JC, PORRECA F: The role of voltage-gated sodium channels in neuropathic pain. Curr Opin Neurobiol 13: 291-297, 2003.
18. LIU CN, MICHAELIS M, AMIR R, DEVOR M: Spinal nerve injury enhances subthreshold membrane potential oscillations in DRG neurons: relation to neuropathic pain. J Neurophysiol 84: 205-215, 2000.
19. LLINAS RR, GRACE AA, YAROM Y: In vitro neurons in mammalian cortical layer 4 exhibit intrinsic oscillatory activity in the 10- to 50-Hz frequency range. Proc Natl Acad Sci USA 88: 897-901, 1991.
20. MAO JL, CHEN LL: Systemic lidocaine for neuropathic pain relief. Pain 87: 7-17, 2000.
21. MICHAELIS M, LIUAND X, JIANG W: Axotomized and intact muscle afferents but no skin afferents develop ongoing discharge of dorsal root ganglion origin after peripheral nerve lesion. J Neurosci 20: 2742-2748, 2000.
22. OBATA K, YAMANAKA H, FUKUOKA T, YI D, TOKUNAGA A, HASHIMOTO N, YOSHIKAWA H, NOGUCHI K: Contribution of injured and uninjured dorsal root ganglion neurons to pain behavior and the changes in gene expression follow chronic constriction injury of the sciatic nerve in rat. Pain 101: 65-77, 2003.
23. PAPE HC, DRIESANG RB: Ionic mechanisms of intrinsic oscillations in neurons of the basolateral amygdaloid complex. J Neurophysiol 79: 217-226, 1998.
24. REBOREDA A, SANCHEZ E, ROMERO M, LAMAS JA: Intrinsic spontaneous activity and subthreshold oscillations in neurons of the rat dorsal column nuclei in culture. J Physiol Lond 191-205, 2003.
25. RIZZO MA, KOCSIS JD, WAXMAN SG: Slow sodium conductances of dorsal root ganglion neurons: intraneural homogeneity and interneuronal heterogeneity. J Neurophysiol 720: 2796-2815, 1994.
26. WU N, HSIAO CF, CHANDLER SH: Membrane resonance and subthreshold membrane oscillations in mesencephalic V neurons: participants in burst generation. J Neurosci 21: 3729-3739, 2001.
27. XING JL, HU SJ, JIAN Z, DUAN JH: Subthreshold membrane potential oscillation mediates the excitatory effect of norepinephrine in chronically compressed dorsal root ganglion neurons in the rat. Pain 105: 177-183, 2003.
28. XING JL, HU SJ, LONG KP: Subthreshold membrane potential oscillations of type A neurons in injured DRG. Brain Res 901: 128-136, 2001.
29. YOON YW, NA HS, CHUNG JM: Contributions of injured and intact afferents to neuropathic pain in an experimental rat model. Pain 64: 27-36, 1996.
30. ZHANG XF, MCKENNA DG, BRIGGS CA: Epibatidine, a nicotinic acetylcholine receptor agonist, inhibits the capsaicin responses in dorsal root ganglion neurons. Brain Res 919: 166-178, 2001.