Extralesional detection and load of human papillomavirus DNA: A possible marker of preclinical tumor spread in cervical cancer

Journal of Lower Genital Tract Disease

Volumn 12, Issue 3, 2008, Pages 204-209

  Lillo, Flavia ^a   Galli, Laura ^b   Lodini, Sara ^b   Taccagni, Gianluca ^b   Ferrari, Augusto ^c   Origoni, Massimo ^c  

^a Laboratory of Virology   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

Cervical cancer; HPV; HPVDNA; Human papillomavirus; Lymph node metastases; Viral load

Indexed keywords

VIRUS DNA; PARAFFIN;

ARTICLE; CANCER INVASION; CANCER RISK; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; LYMPH NODE; LYMPH NODE METASTASIS; PREVALENCE; REAL TIME POLYMERASE CHAIN REACTION; UTERINE CERVIX; UTERINE CERVIX CANCER; VIRUS DETECTION; VIRUS LOAD; VIRUS TYPING; WART VIRUS; ADENOCARCINOMA; ADENOSQUAMOUS CARCINOMA; BLOOD; HUMAN PAPILLOMAVIRUS TYPE 16; ISOLATION AND PURIFICATION; PATHOLOGY; PROGNOSIS; RETROSPECTIVE STUDY; SQUAMOUS CELL CARCINOMA; UTERINE CERVIX TUMOR; VIROLOGY;

ADENOCARCINOMA; CARCINOMA, ADENOSQUAMOUS; CARCINOMA, SQUAMOUS CELL; CERVIX UTERI; DNA, VIRAL; FEMALE; HUMAN PAPILLOMAVIRUS 16; HUMANS; LYMPH NODES; LYMPHATIC METASTASIS; PARAFFIN EMBEDDING; PROGNOSIS; RETROSPECTIVE STUDIES; UTERINE CERVICAL NEOPLASMS; VIRAL LOAD;

EID: 50549099205     PISSN: 10892591     EISSN: None     Source Type: Journal    
DOI: 10.1097/LGT.0b013e318161429e     Document Type: Article

References (26)

1. Yuan C, Wang P, Lai C, Tsu E, Yen M, Ng H. Recurrence and survival analyses of 1,115 cervical cancer patients treated with radical hysterectomy. Gynecol Obstet Invest 1999;47:127-32.
2. Lentz SE, Muderspach LI, Felix JC, Ye W, Groshen S, Amezcua CA. Identification of micrometastases in histologi-cally negative lymph nodes of early-stage cervical cancer patients. Obstet Gynecol 2004;103:1204-10.
3. Delgado G, Bundy B, Zaino R, Sevin BU, Creasman WT, Major F. Prospective surgical-pathological study of disease-free interval in patients with stage IB squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study. Gynecol Oncol 1990;38:352-7.
4. Fuller AF Jr, Elliott N, Kosloff C, Hoskins WJ, Lewis JL Jr. Determinants of increased risk for recurrence in patients undergoing radical hysterectomy for stage IB and IIA carcinoma of the cervix. Gynecol Oncol 1989;33:34-9.
5. Van Trappen PO, Gyselman VG, Lowe DG, Ryan A, Oram DH, Bosze P, et al. Molecular quantification and mapping of lymph-node micrometastases in cervical cancer. Lancet 2001;357:15-20.
6. Sapy T, Hernadi Z, Konya J, Lukacsko L. Poor clinical outcome in early stage cervical cancer with human papilloma-virus-18 positive lymph nodes. Eur J Obstet Gynecol Reprod Biol 2000;90:93-5.
7. Plaza JA, Ramirez NC, Nuovo GJ. Utility of HPV analysis for evaluation of possible metastatic disease in women with cervical cancer. Int J Gynecol Pathol 2004;23:7-12.
8. Czegledy J, Iosif C, Forslund O, Willen R, Hansson BG. Detection of human papillomavirus DNA in lymph nodes extirpated at radical surgery for cervical cancer is not predictive of recurrence. J Med Virol 1998;54:183-5.
9. Kobayashi Y, Yoshinouchi M, Tianqi G, Nakamura K, Hongo A, Kamimura S, et al. Presence of human papilloma-virus DNA in pelvic lymph nodes can predict unexpected recurrence of cervical cancer in patients with histologically negative lymph nodes. Clin Cancer Res 1998;4:979-83.
10. Chan PK, Chan DP, To KF, Yu MY, Cheung JL, Cheng AF. Evaluation of extraction methods from paraffin wax embedded tissues for PCR amplification of human and viral DNA. J Clin Pathol 2001;54:401-3.
11. Kleter B, van Doorn LJ, ter Schegget J, Schrauwen L, van Krimpen K, Burger M, et al. Novel short-fragment PCR assay for highly sensitive broad-spectrum detection of ano-genital human papillomaviruses. Am J Pathol 1998;153: 1731-9.
12. Lillo FB, Lodini S, Ferrari D, Stayton C, Taccagni G, Galli L, et al. Determination of human papillomavirus (HPV) load and type in high-grade cervical lesions surgically resected from HIV-infected women during follow-up of HPV infection. Clin Infect Dis 2005;40:451-7.
13. Piver MS, Rutledge F, Smith JP. Five classes of extended hysterectomy for women with cervical cancer. Obstet Gynecol 1974;44:265-72.
14. Yang HJ, Liu VW, Tsang PC, Yip AM, Tam KF, Wong LC, et al. Quantification of human papillomavirus DNA in the plasma of patients with cervical cancer. Int J Gynecol Cancer 2004;14:903-10.
15. Dong SM, Pai SI, Rha SH, Hildesheim A, Kurman RJ, Schwartz PE, et al. Detection and quantitation of human papillomavirus DNA in the plasma of patients with cervical carcinoma. Cancer Epidemiol Biomarkers Prev 2002;11:3-6.
16. Herzog TJ. New approaches for the management of cervical cancer. Gynecol Oncol 2003;90(3 Pt 2):S22-7.
17. Lukaszuk K, Liss J, Wozniak I, Sliwinski W, Emerich J, Wojcikowski C. HPV and histological status of pelvic lymph node metastases in cervical cancer: a prospective study. J Clin Pathol 2004;57:472-6.
18. Chan PK, Yu MM, Cheung TH, To KF, Lo KW, Cheung JL, et al. Detection and quantitation of human papillomavirus DNA in primary tumour and lymph nodes of patients with early stage cervical carcinoma. J Clin Virol 2005; 33:201-5.
19. Blaheta HJ, Schittek B, Breuninger H, Garbe C. Detection of micrometastasis in sentinel lymph nodes of patients with primary cutaneous melanoma. Recent Results Cancer Res 2001;158:137-46.
20. Schwartz GF, Giuliano AE, Veronesi U. Proceedings of the consensus conference on the role of sentinel lymph node biopsy in carcinoma of the breast, April 19-22, 2001, Philadelphia, Pennsylvania. Cancer 2002;94:2542-51.
21. Levenback C, Burke TW, Gershenson DM, Morris M, Malpica A, Ross MI. Intraoperative lymphatic mapping for vulvar cancer. Obstet Gynecol 1994;84:163-7.
22. de Hullu JA, Hollema H, Piers DA, Verheijen RH, van Diest PJ, Mourits MJ, et al. Sentinel lymph node procedure is highly accurate in squamous cell carcinoma of the vulva. J Clin Oncol 2000;18:2811-6.
23. Levenback C, Coleman RL, Burke TW, Lin WM, Erdman W, Deavers M, et al. Lymphatic mapping and sentinel node identification in patients with cervix cancer undergoing radical hysterectomy and pelvic lymphadenectomy. J Clin Oncol 2002;20:688-93.
24. Barranger E, Coutant C, Cortez A, Uzan S, Darai E. Sentinel node biopsy is reliable in early-stage cervical cancer but not in locally advanced disease. Ann Oncol 2005;16: 1237-42.
25. Lambaudie E, Collinet P, Narducci F, Sonoda Y, Papageorgiou T, Carpentier P, et al. Laparoscopic identification of sentinel lymph nodes in early stage cervical cancer: prospective study using a combination of patent blue dye injection and technetium radiocolloid injection. Gynecol Oncol 2003;89:84-7.
26. Fule T, Csapo Z, Mathe M, Tatrai P, Laszlo V, Papp Z, et al. Prognostic significanceofhigh-risk HPV statusin advanced cervical cancers and pelvic lymph nodes. Gynecol Oncol 2006; 100:570-8.