Identification of micrometastases in histologically negative lymph nodes of early-stage cervical cancer patients

Obstetrics and Gynecology

Volumn 103, Issue 6, 2004, Pages 1204-1210

  Lentz, Scott E ^a,b   Muderspach, Laila I ^a   Felix, Juan C ^a   Ye, Wei ^a   Groshen, Susan ^a   Amezcua, Charles A ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b KAISER PERMANENTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN; CYTOKERATIN AE1; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; CAM 5.2 ANTIGEN; KERATIN;

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER RECURRENCE; CANCER STAGING; DISEASE ASSOCIATION; EARLY DIAGNOSIS; FEMALE; HISTOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MELANOMA; PELVIS LYMPH NODE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TUMOR VOLUME; UTERINE CERVIX CANCER; ETHNOLOGY; HISPANIC; IMMUNOLOGY; LYMPH NODE; METABOLISM; METASTASIS; PATHOLOGY; PELVIS; PROGNOSIS; SQUAMOUS CELL CARCINOMA; UNITED STATES; UTERINE CERVIX TUMOR;

ADULT; BIOLOGICAL MARKERS; CALIFORNIA; CARCINOMA, SQUAMOUS CELL; FEMALE; HISPANIC AMERICANS; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINS; LYMPH NODES; LYMPHATIC METASTASIS; NEOPLASM STAGING; PELVIS; PROGNOSIS; UTERINE CERVICAL NEOPLASMS;

EID: 3042534079     PISSN: 00297844     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.AOG.0000125869.78251.5e     Document Type: Article

References (19)

1. Piver MS, Marchetti DL, Patton T, Halpern J, Blumenson L, Driscoll DL. Radical hysterectomy and pelvic lymphadenectomy versus radiation therapy for small (< 3 cm) stage IB cervical carcinoma. Am J Clin Oncol 1988;11: 21-4.
2. Yuan C, Wang P, Lai C, Tsu E, Yen M, Ng M. Recurrence and survival analysis of 1,115 cervical cancer patients treated with radical hysterectomy. Gynecol Obstet Invest 1999;47:127-32.
3. Delgado G, Bundy B, Zaino R, Sevin BU, Creasman WT, Major F. Prospective surgical-pathological study of disease-free interval in patients with stage IB squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study. Gynecol Oncol 1990;38:352-7.
4. Fuller AF Jr, Elliott N, Kosloff C, Hoskins WJ, Lewis JL Jr. Determinants of increased risk for recurrence in patients undergoing radical hysterectomy for stage IB and IIA carcinoma of the cervix. Gynecol Oncol 1989;33:34-9.
5. Ludwig Breast Cancer Study Group. Prognostic importance of occult axillary lymph node micrometastases from breast cancers. Lancet 1990;335:1565-8.
6. American Joint Committee on Cancer. AJCC cancer staging manual. 6th ed. New York (NY): Springer-Verlag; 2002.
7. Cote RJ, Peterson HF, Chaiwun B, Gelber RD, Goldhirsch A, Castiglione-Gertsch M, et al. Role of immunohistochemical detection of lymph-node metastases in management of breast cancer. International Breast Cancer Study Group. Lancet 1999;354:896-900.
8. Masuda N, Tamaki Y, Sakita I, Ooka M, Ohnishi T, Kadota M, et al. Clinical significance of micrometastases in axillary lymph nodes assessed by reverse transcription-polymerase chain reaction in breast cancer patients. Clin Cancer Res 2000;6:4176-85.
9. Blaheta HJ, Schittek B, Breuninger H, Garbe C. Detection of micrometastasis in sentinel lymph nodes of patients with primary cutaneous melanoma. Recent Results Cancer Res 2001;158:137-46.
10. Van Trappen PO, Gyselman VG, Lowe DG, Ryan A, Oram DH, Bozse P, et al. Molecular quantification and mapping of lymph-node micrometastases in cervical cancer. Lancet 2001;357:15-20.
11. Gart J. Point and interval estimation of the common odds ratio in the combination of 2 × 2 tables with fixed marginals. Biometrika 1970;57:471-5.
12. Burnett AF, Barnes WA, Johnson JC, Grendys E, Willett GD, Barter JF, et al. Prognostic significance of polymerase chain reaction detected human papillomavirus of tumors and lymph nodes in surgically treated stage IB cervical cancer. Gynecol Oncol 1992;47:343-7.
13. Baay MFD, Koudstaal J, Hollema H, Duk JM, Burger MPM, Quint WGV, et al. Detection of HPV-16 DNA by PCR in histologically cancer free lymph nodes from patients with cervical cancer. J Clin Path 1997;50:960-1.
14. Czegledy J, Iosif C, Forslund O, Willen R, Hansson BG. Detection of human papilloma virus DNA in lymph nodes extirpated at radical surgery for cervical cancer is not predictive of recurrence. J Med Virol 1998;54:183-5.
15. Van Trappen PO, Pepper MS. Lymph angiogenesis and lymph node microdissemination. Gynecol Oncol 2001;82:1-3.
16. Mansi JL, Gogas H, Bliss JM, Gazet JC, Berger U, Coombes RC. Outcome of primary-breast-cancer patients with micrometastases: a long-term follow-up study. Lancet 1999;354:197-202.
17. Shi SR, Cote RJ, Taylor CR. Antigen retrieval immunohistochemistry: past, present, and future. J Histochem Cytochem 1997;45:327-43.
18. McNeil C. Micrometastases matter in new melanoma staging system.J Natl Cancer Inst 2000;92:1370-1.
19. Armitage P. Test for linear trend in proportions and frequencies. Biometrics 1955;11:375-86.