On multiple testing, validation of gene expression profiling, and translational research

Chinese Medical Journal

Volumn 121, Issue 13, 2008, Pages 1247-

  Xie, Xian Jin ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; ANALYTIC METHOD; CANCER CELL CULTURE; CANCER GENETICS; CANCER PATIENT; CANCER RESISTANCE; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENETIC SCREENING; GENOME ANALYSIS; LETTER; MEDICAL RESEARCH; MULTIDRUG RESISTANCE; PANCREAS CANCER; PREDICTION; REFERENCE VALUE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VALIDATION STUDY; WESTERN BLOTTING; DNA MICROARRAY; DRUG RESISTANCE; HUMAN; METABOLISM; NOTE; PANCREAS TUMOR;

DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION PROFILING; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PANCREATIC NEOPLASMS;

EID: 50549093008     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00029330-200807010-00020     Document Type: Letter

References (5)

1. Zhao YP, Chen G, Feng B, Zhang TP, Ma EL, Wu YD. Microarray analysis of gene expression profile of multidrug resistance in pancreatic cancer. Chin Med J 2007; 120: 1743-1752.
2. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B 1995; 57: 289-300.
3. Whitehurst AW, Bodemann BO, Cardenas J, Ferguson D, Girard L, Peyton M, et al. Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature 2007; 446: 815-819.
4. Xie XJ, Whitehurst A, White M. A practical efficient approach in high throughput screening: using FDR and fold change. Nature Protocols 2007; DOI: 10.1038/nprot.2007.188.
5. Simon R. Roadmap for developing and validating therapeutically relevant genomic classifiers. J Clin Oncol 2005; 23: 7332-7341.