Effects of active and inactive phospholipase D2 on signal transduction, adhesion, migration, invasion, and metastasis in EL4 lymphoma cells

Molecular Pharmacology

Volumn 74, Issue 3, 2008, Pages 574-584

  Knoepp, Stewart M ^b   Chahal, Manpreet S ^a   Xie, Yuhuan ^a   Zhang, Zhihong ^a   Brauner, Daniel J ^a   Hallman, Mark A ^b   Robinson, Stephanie A ^b   Han, Shujie ^a   Imai, Masaki ^b   Tomlinson, Stephen ^b   Meier, Kathryn E ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOCAL ADHESION KINASE; IONOMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; OKADAIC ACID; PHOSPHOLIPASE D2; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC TRANSFECTION; LYMPHOMA CELL LINE; MALE; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; LYMPHOMA; MALE; MICE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PHENOTYPE; PHOSPHOLIPASE D; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 50449089931     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.107.040105     Document Type: Article

References (47)

1. Ahn BH, Kim SY, Kim EH, Choi KS, Kwon TK, Lee YH, Chang JS, Kim MS, Jo YH, and Min DS (2003) Transmodulation between phospholipase D and c-Src enhances cell proliferation. Mol Cell Biol 23:3103-3115.
2. Bae YS and Ryu SH (2001) ATP-induced focal adhesion kinase activity is negatively modulated by phospholipase D2 in PC12 cells. Exp Mol Med 33:150-155.
3. Bradshaw CD, Ella KM, Qi C, Sansbury HM, Wisehart-Johnson AE, and Meier KE (1996) Effects of phorbol ester on phospholipase D and mitogen-activated protein kinase activities in T-lymphocyte cell lines. Immunol Lett 53:69-76.
4. Chen JS and Exton JH (2004) Regulation of phospholipase D2 activity by protein kinase C. J Biol Chem 279:22076-22083.
5. Choi WS, Hiragun T, Lee JH, Kim YM, Kim HP, Chahdi A, Her E, Han JW, and Beaven MA (2004) Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr. Mol Cell Biol 24:6980-6992.
6. Cockcroft S (2001) Signalling roles of mammalian phospholipase D1 and D2. Cell Mol Life Sci 58:1674-1687.
7. Colley WC, Sung TC, Roll R, Jenco J, Hammond SM, Altshuller Y, Bar-Sagi D, Morris AJ, and Frohman MA (1997) Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization. Curr Biol 7:191-201.
8. Delon C, Manifava M, Wood E, Thompson D, Krugmann S, Pyne S, and Ktistakis NT (2004) Sphingosine kinase 1 is an intracellular effector of phosphatidic acid. J Biol Chem 279:44763-44774.
9. Diaz O, Mébarek-Azzam S, Benzaria A, Dubois M, Lagarde M, Némoz G, and Prigent AF (2005) Disruption of lipid rafts stimulates phospholipase D activity in human lymphocytes: implication in the regulation of immune function. J Immunol 175: 8077-8086.
10. Di Fulvio M, Frondorf K, Henkels KM, Lehman N, and Gomez-Cambronero J (2007) The Grb2/PLD2 interaction is essential for lipase activity, intracellular localization, and signaling in response to EGF. J Mol Biol 367:814-824.
11. Divecha N, Roefs M, Halstead JR, D'Andrea S, Fernandez-Borga M, Oomen L, Saqib KM, Wakelam MJ, and D'Santos C (2000) Interaction of the type 1 alpha PIP kinase with phospholipase D: a role for the local generation of phosphatidylinositol 4,5-bisphosphate in the regulation of PLD2 activity. EMBO J 19:5440-5449.
12. Ella KM, Qi C, McNair AF, Park JH, Wisehart-Johnson AE, and Meier KE (1997) Phospholipase D activity in PC12 cells. Effects of overexpression of α2A-adrenergic receptors. J Biol Chem 272:12909-12912.
13. Fang Y, Vilella-Bach M, Bachmann R, Flanigan A, and Chen J (2001) Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science 294:1942-1945.
14. Foster DA and Xu L (2003) Phospholipase D in cell proliferation and cancer. Mol Cancer Res 1:789-800.
15. Ghosh S, Strum JC, Sciorra VA, Daniel L, and Bell RM (1996) Raf-1 kinase possesses distinct binding domains for phosphatidylserine and phosphatidic acid. J Biol Chem 271:8472-8480.
16. Gibbs TC and Meier KE (2000) Expression and regulation of phospholipase D isoforms in mammalian cell lines. J Cell Physiol 182:77-87.
17. Heo K, Ha SH, Chae YC, Lee S, Oh YS, Kim YH, Kim SH, Kim JH, Mizoguchi A, Itoh TJ, et al. (2006) PLD2 forms a functional complex with mTOR-raptor to transduce mitogenic signals. Cell Signal 18:2182-2192.
18. Han S, Knoepp SM, Hallman MA, and Meier KE (2007) RasGRP confers the phorbol ester-sensitive phenotype to EL4 lymphoma cells. Mol Pharmacol 71:314-322.
19. Hiroyama M and Exton JH (2005) Localization and regulation of phospholipase D2 by ARF6. J Cell Biochem 95:149-164.
20. Joseph T, Wooden R, Bryant A, Zhong M, Lu Z, and Foster DA (2001) Transformation of cells overexpressing a tyrosine kinase by phospholipase D1 and D2. Biochem Biophys Res Commun 289:1019-1024.
21. Kim SW, Hayashi M, Lo JF, Yang Y, Yoo JS, and Lee JD (2003) ADP-ribosylation factor 4 small GTPase mediates epidermal growth factor receptor-dependent phospholipase D2 activation. J Biol Chem 278:2661-2668.
22. Kinsky SC, Loader JE, and Benedict SH (1989) Phorbol ester activation of phospholipase D in human monocytes but not peripheral blood lymphocytes. Biochem Biophys Res Commun 162:788-793.
23. Ku H and Meier KE (2000) Phosphorylation of paxillin via the ERK mitogenactivated protein kinase cascade in El4 thymoma cells. J Biol Chem 275:11333-11340.
24. Lee CS, Kim IS, Park JB, Lee MN, Lee HY, Suh PG, and Ryu SH (2006) The phox homology domain of phospholipase D activates dynamin ATPase activity and accelerates EGFR endocytosis. Nat Cell Biol 8:477-483.
25. Lee S, Park JB, Kim JH, Kim Y, Kim JH, Shin KJ, Lee JS, Ha SH, Suh PG, and Ryu SH (2001) Actin directly interacts with phospholipase D, inhibiting its activity. J Biol Chem 276:28252-28260.
26. Li F and Malik KU (2005) Angiotensin II-induced Akt activation through the epidermal growth factor receptor in vascular smooth muscle cells is mediated by phospholipid metabolites derived by activation of phospholipase D. J Pharmacol Exp Ther 312:1043-1054.
27. Meier KE and Gibbs TC (1999) Signal Transduction, a Practical Approach (Milligan G, ed) pp 301-319, Oxford University Press, Oxford.
28. Meier KE, Gibbs TC, Knoepp SM, and Ella KM (1999) Expression of phospholipase D isoforms in mammalian cells. Biochem Biophys Acta 1439:199-213.
29. Min DS, Kwon TK, Park WS, Chang JS, Park SK, Ahn BH, Ryoo ZY, Lee YH, Lee YS, Rhie DJ, et al. (2001) Neoplastic transformation and tumorigenesis associated with overexpression of phospholipase D isozymes in cultured murine fibroblasts. Carcinogenesis 22:1641-1647.
30. Palicz A, Foubert TR, Jesaitis AJ, Marodi L, and McPhail LC (2001) Phosphatidic acid and diacylglycerol directly activate NADPH oxidase by interacting with enzyme components. J Biol Chem 276:3090-3097.
31. Porcelli AM, Ghelli A, Hrelia S, and Rugolo M (2002) Phospholipase D stimulation is required for sphingosine-1-phosphate activation of actin stress fibre assembly in human airway epithelial cells. Cell Signal 14:75-81.
32. Powner DJ, Payne RM, Pettitt TR, Giudici ML, Irvine RF, and Wakelam MJ (2005) Phospholipase D2 stimulates integrin-mediated adhesion via phosphatidylinositol 4-phosphate 5-kinase Igb. J Cell Sci 118:2975-2986.
33. Preininger AM, Henage LG, Oldham WM, Yoon EJ, Hamm HE, and Brown HA (2006) Direct modulation of phospholipase D activity by Gbg. Mol Pharmacol 70:311-318.
34. Rodrik V, Zheng Y, Harrow F, Chen Y, and Foster DA (2005) Survival signals generated by estrogen and phospholipase D in MCF-7 breast cancer cells are dependent on Myc. Mol Cell Biol 25:7917-7925.
35. Sansbury HM, Wisehart-Johnson AE, Qi C, Fulwood S, and Meier KE (1997) Effects of protein kinase C activators on phorbol ester-sensitive and -resistant EL4 thymoma cells. Carcinogenesis 18:1817-1824.
36. Shen Y, Zheng Y, and Foster DA (2002) Phospholipase D2 stimulates cell protrusion in v-Src-transformed cells. Biochem Biophys Res Commun 293:201-206.
37. Siddiqi AR, Srajer GE, and Leslie CC (2000) Regulation of human PLD1 and PLD2 by calcium and protein kinase C. Biochem Biophys Acta 1497:103-114.
38. Slaaby R, Jensen T, Hansen HS, Frohman MA, and Seedorf K (1998) PLD2 complexes with the EGF receptor and undergoes tyrosine phosphorylation at a single site upon agonist stimulation. J Biol Chem 273:33722-33727.
39. Sung TC, Roper RL, Zhang Y, Rudge SA, Temel R, Hammond SM, Morris AJ, Moss B, Engebrecht J, and Frohman MA (1997) Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity. EMBO J 16:4519-4530.
40. Symons M (2000) Adhesion signaling: PAK meets Rac on solid ground. Curr Biol 10:R535-R537.
41. Xia H, Nho RS, Kahm J, Kleidon J, and Henke CA (2004) Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via b1 integrin viability signaling pathway. J Biol Chem 279:33024-33034.
42. Xie Y, Gibbs TC, Mukhin YV, and Meier KE (2002) Role for 18:1 lysophosphatidic acid as an autocrine mediator in prostate cancer cells. J Biol Chem 277:32516-32526.
43. Xie Y and Meier KE (2002) Assays for phospholipase D reaction products. Methods Enzymol 345:294-305.
44. Yamada Y, Hamajima N, Kato T, Iwata H, Yamamura Y, Shinoda M, Suyama M, Mitsudomi T, Tajima K, Kusakabe S, et al. (2003) Association of a polymorphism of the phospholipase D2 gene with the prevalence of colorectal cancer. J Mol Med 81:126-131.
45. Zhang H, Zhang S, Cheung NK, Ragupathi G, and Livingston PO (1998) Antibodies against GD2 ganglioside can eradicate syngeneic cancer micrometastases. Cancer Res 58:2844-2849.
46. Zhao Y, Ehara H, Akao Y, Shamoto M, Nakagawa Y, Banno Y, Deguchi T, Ohishi N, Yagi K, and Nozawa Y (2000) Increased activity and intranuclear expression of phospholipase D2 in human renal cancer. Biochem Biophys Res Commun 278:140-143.
47. Zhong M, Joseph T, Jackson D, Beychenok S, and Foster DA (2002) Elevated phospholipase D activity induces apoptosis in normal rat fibroblasts. Biochem Biophys Res Commun 298:474-477.