Cloning, gene organization and identification of an alternative splicing process in lecithin:retinol acyltransferase cDNA from human liver

Gene

Volumn 341, Issue 1-2, 2004, Pages 181-188

  Zolfaghari, Reza ^a   Ross, A Catharine ^a  

^a S 126 Henderson Bldg P ^*  (United States)

Author keywords

Splicing variant; Untranslated region

Indexed keywords

ADENINE; CCAAT BINDING FACTOR; COMPLEMENTARY DNA; GENOMIC DNA; LECITHIN RETINOL ACYLTRANSFERASE; MESSENGER RNA; POLYNUCLEOTIDE; RETINOL ESTER; TRANSCRIPTION FACTOR SP1; URACIL;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ALTERNATIVE RNA SPLICING; AMINO ACID COMPOSITION; ARTICLE; CONTROLLED STUDY; EXON; GENBANK; GENE IDENTIFICATION; GENETIC CONSERVATION; GENETIC ORGANIZATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN GENOME; HUMAN TISSUE; INTRON; LIVER; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PIGMENT CELL; PIGMENT EPITHELIUM; POLYADENYLATION; PREDICTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN VARIANT; RNA ANALYSIS; RNA SEQUENCE; SIGNAL TRANSDUCTION; TATA BOX; TESTIS; TISSUE DISTRIBUTION; TISSUE SPECIFICITY; TRANSCRIPTION INITIATION SITE;

3' UNTRANSLATED REGIONS; 5' UNTRANSLATED REGIONS; ACYLTRANSFERASES; ALTERNATIVE SPLICING; BINDING SITES; CLONING, MOLECULAR; DNA, COMPLEMENTARY; EXONS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES; HUMANS; INTRONS; ISOENZYMES; LIVER; MALE; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; TATA BOX; TESTIS;

EID: 5044237775     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2004.06.043     Document Type: Article

References (28)

1. V. Anantharaman, and L. Aravind Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes Genome Biol. 4 2003 R11
2. F. Andreola, V. Giandomenico, R. Spero, and L.M. De Luca Expression of a smaller lecithin:retinol acyl transferase transcript and reduced retinol esterification in MCF-7 cells Biochem. Biophys. Res. Commun. 279 2000 920 924
3. M.L. Batten, Y. Imanishi, T. Maeda, D.C. Tu, A.R. Moise, D. Bronson, D. Possin, R.N. Van Gelder, W. Baehr, and K. Palczewski Lecithinâ€" retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver J. Biol. Chem. 279 2004 10422 10432
4. C.Y. Chen, and A.B. Shyu AU-rich elements: characterization and importance in mRNA degradation Trends Biochem. Sci. 20 1995 465 470
5. B. Conne, A. Stutz, and J.D. Vassalli The 3′ untranslated region of messenger RNA: a molecular "hotspot" for pathology? Nat. Med. 6 2000 637 641
6. X. Guo, A. Ruiz, R.R. Rando, D. Bok, and L.J. Gudas Esterification of all-trans-retinol in normal human epithelial cell strains and carcinoma lines from oral cavity, skin and breast: reduced expression of lecithin:retinol acyltransferase in carcinoma lines Carcinogenesis 21 2000 1925 1933
7. X. Guo, D.M. Nanus, A. Ruiz, R.R. Rando, D. Bok, and L.J. Gudas Reduced levels of retinyl esters and vitamin A in human renal cancers Cancer Res. 61 2001 2774 2781
8. X. Guo, B.S. Knudsen, D.M. Peehl, A. Ruiz, D. Bok, R.R. Rando, J.S. Rhim, D.M. Nanus, and L.J. Gudas Retinol metabolism and lecithin:retinol acyltransferase levels are reduced in cultured human prostate cancer cells and tissue specimens Cancer Res. 62 2002 1654 1661
9. W.J. Jahng, L. Xue, and R.R. Rando Lecithin retinol acyltransferase is a founder member of a novel family of enzymes Biochemistry 42 2003 12805 12812
10. M. Kozak An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs Nucleic Acids Res. 15 1987 8125 8148
11. P.N. MacDonald, and D.E. Ong A lecithin:retinol acyltransferase activity in human and rat liver Biochem. Biophys. Res. Commun. 156 1988 157 163
12. D.E. Ong, P.C. Lucas, B. Kakkad, and T.C. Quick Ontogeny of two vitamin A-metabolizing enzymes and two retinol-binding proteins present in the small intestine of the rat J. Lipid Res. 32 1991 1521 1527
13. A.C. Ross Cellular metabolism and activation of retinoids: roles of cellular retinoid-binding proteins FASEB J. 7 1993 317 327
14. A.C. Ross Retinoid production and catabolism: role of diet in regulating retinol esterification and retinoic acid oxidation J. Nutr. 133 2003 291S 296S
15. A.C. Ross, and R. Zolfaghari Regulation of hepatic retinol metabolism: perspectives from studies on vitamin A status J. Nutr. 134 2004 269S 275S
16. A.C. Ross, R. Zolfaghari, and J. Weisz Vitamin A: recent advances in the biotransformation, transport, and metabolism of retinoids Curr. Opin. Gastroenterol. 17 2001 184 192
17. A. Ruiz, A. Winston, Y.H. Lim, B.A. Gilbert, R.R. Rando, and D. Bok Molecular and biochemical characterization of lecithin retinol acyltransferase J. Biol. Chem. 274 1999 3834 3841
18. A. Ruiz, M.H. Kuehn, J.L. Andorf, E. Stone, G.S. Hageman, and D. Bok Genomic organization and mutation analysis of the gene encoding lecithin retinol acyltransferase in human retinal pigment epithelium Invest. Ophthalmol. Visual Sci. 42 2001 31 37
19. J.C. Saari, and D.L. Bredberg CoA- and non-CoA-dependent retinol esterification in retinal pigment epithelium J. Biol. Chem. 263 1988 8084 8090
20. J. Sambrook, and D.W. Russell Molecular Cloning: A Laboratory Manual 3rd ed. 2001 Cold Spring Harbor Laboratory Press Cold Spring Harbor, NY
21. M.C. Schmitt, and D.E. Ong Expression of cellular retinol-binding protein and lecithinâ€"retinol acyltransferase in developing rat testis Biol. Reprod. 49 1993 972 979
22. D.P. Simmons, F. Andreola, and L.M. De Luca Human melanomas of fibroblast and epithelial morphology differ widely in their ability to synthesize retinyl esters Carcinogenesis 23 2002 1821 1830
23. R.W. Yost, E.H. Harrison, and A.C. Ross Esterification by rat liver microsomes of retinol bound to cellular retinol-binding protein J. Biol. Chem. 263 1988 18693 18701
24. H.C. Zhan, L.J. Gudas, D. Bok, R. Rando, D.M. Nanus, and S.K. Tickoo Differential expression of the enzyme that esterifies retinol, lecithin:retinol acyltransferase, in subtypes of human renal cancer and normal kidney Clin. Cancer Res. 9 2003 4897 4905
25. R. Zolfaghari, and A.C. Ross Lecithin:retinol acyltransferase from mouse and rat liver. CDNA cloning and liver-specific regulation by dietary vitamin a and retinoic acid J. Lipid Res. 41 2000 2024 2034
26. R. Zolfaghari, and A.C. Ross Lecithin:retinol acyltransferase expression is regulated by dietary vitamin A and exogenous retinoic acid in the lung of adult rats J. Nutr. 132 2002 1160 1164
27. R. Zolfaghari, X. Chen, and E.A. Fisher Simple method for extracting RNA from cultured cells and tissue with guanidine salts Clin. Chem. 39 1993 1408 1411
28. R. Zolfaghari, Y. Wang, Q. Chen, A. Sancher, and A.C. Ross Cloning and molecular expression analysis of large and small lecithin:retinol acyltransferase mRNAs in the liver and other tissues of adult rats Biochem. J. 368 2002 621 631