Simultaneous quantitation of zidovudine and zidovudine monophosphate from plasma, amniotic fluid and tissues by micellar capillary electrophoresis

Biomedical Chromatography

Volumn 18, Issue 8, 2004, Pages 523-531

  Alnouti, Yazen ^a   White, Catherine A ^a   Bartlett, Michael G ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Capillary electrophoresis; Enzymatic degradation; Validation; Zidovudine; Zidovudine monophosphate

Indexed keywords

CAPILLARY ELECTROPHORESIS; DISEASES; EXTRACTION; FUSED SILICA; HISTOLOGY; OBSTETRICS; PHASE SEPARATION; RATS; SODIUM DODECYL SULFATE; VIRUSES;

AMNIOTIC FLUID; ENZYMATIC DEGRADATION; HUMAN IMMUNODEFICIENCY VIRUS; MICELLARS; MONOPHOSPHATES; RAT PLASMA; VALIDATION; VERTICAL TRANSMISSION; ZIDOVUDINE; ZIDOVUDINE MONOPHOSPHATE;

TISSUE;

3' AZIDOURIDINE; ACETONITRILE; BUFFER; DODECYL SULFATE SODIUM; DRUG METABOLITE; PHOSPHATE; UNCLASSIFIED DRUG; ZIDOVUDINE; ZIDOVUDINE DERIVATIVE; ZIDOVUDINE MONOPHOSPHATE;

ACCURACY; AMNION FLUID LEVEL; ANALYTICAL ERROR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAPILLARY ELECTROPHORESIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG STRUCTURE; DRUG TISSUE LEVEL; ENZYME DEGRADATION; FETUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MATERNAL CARE; MICELLAR CAPILLARY ELECTROPHORESIS; NONHUMAN; PH; PHOSPHORYLATION; PLACENTA; PRECIPITATION; PROTEIN DEPHOSPHORYLATION; QUANTITATIVE ANALYSIS; RAT; SEPARATION TECHNIQUE; SOLID PHASE EXTRACTION; VALIDATION PROCESS; VERTICAL TRANSMISSION; VIRUS TRANSMISSION;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 5044235809     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/bmc.350     Document Type: Article

References (37)

1. Bawdon RE, Sobhi S and Dax J. The transfer of anti-human immunodeficiency virus nucleoside compounds by the term human placenta. American Journal of Obstetrics and Gynecology 1992; 167: 1570-1574.
2. Bloom J, Ortiz J and Rodriguez JF. Azidothymidine triphosphate determination using micellar electrokinetic capillary chromatography. Cellular and Molecular Biology 1997; 43: 1051-1055.
3. Boal JH, Plessinger MA, Reydt CV and Miller RK. Pharmacokinetic and toxicity studies of AZT (zidovudine) following perfusion of human term placenta for 14 hours. Toxicology and Applied Pharmacology 1997; 143: 13-21.
4. Brody SR and Aweeka FT. Pharmacokinetics of intracellular zidoviudine and its phosphorylated metabolites in the absence and presence of stavudine using in vitro human peripheral blood mononuclear cell (PBMC) model. International Journal of Antimicrobial Agents 1997; 9: 131-135.
5. Elisabeth P, Yoshioka M, Sasaki T and Senda M. Separation of nucleotides using miceller electrokinetic capillary chromatography. Journal of Chrmatography A 1998; 806: 199-207.
6. Fan B and Stewart JT. Determination of zidovudine/didanosine/nevirapamine and zidovudine/didanosine/ritonavir in human serum by micellar Electrokinetic chromatography. Journal of Pharmaceutical and Biomedical Analysis 2002; 30: 955-960.
7. Garland M, Szeto HH, Daniel SS, Tropper PJ, Myers MM and Stark RI. Zidovudine kinetics in pregnant baboons. Journal of AIDS 1996; 11: 117-127.
8. Geldart SE and Brown PR. Analysis of nucleotides by capillary electrophoresis. Journal of Chromatography A 1998; 828: 317-336.
9. Good S, Reynolds, DJ, Miranada PD. Simultaneous quantification of zidoviudine and its glucuronide in serum by high performance liquid chromatography. Journal of Chromatography 1988; 431: 123-133.
10. Ho HT and Hitchcock MJ. Cellular pharmacology of 2,3-dideoxy-2,3-didehydrothymidine, a nucleoside analog active against human immunodeficiency virus. Antimicrobial Agents and Chemotherapy 1989; 33: 844-849.
11. Huang CS-H, Boudinot FD and Feldman S. Radioimmunoassay for zidovudine in rat placenta and fetus. Journal of Pharmaceutical and Biomedical Analysis 1996; 14: 855-860.
12. Landesman S, Minkoff H, Holman S, Mccalla S and Sijin O. Serosurvey of human immunodeficiency virus infection in parturients. Implications for human immunodeficiency virus testing programs of pregnant women. JAMA 1987; 258: 2701-2703.
13. Lecoq A-F. Fraction collection after an optimized miceller electrkinetic capillary chromatographic separation of nucleic acid constituents. Journal of Chromatography 1993; 638: 363-373.
14. Liebes L, Mendoza S, Wilson D and Dancis J. Transfer of zidovudine (AZT) by human placenta. Journal of Infectious Disease 1990; 161: 203-207.
15. Liebes L, Mendoza S and Dancis J. Further observations on zidovudine transfer and metabolism by human placenta, AIDS (London) 1993; 7: 589-600.
16. Lopez-Anaya A, Unadkat JD, Schumann LA and Smith AL. Pharmacokinetics of zdovudine (azidothymidine). I. Transplacental transfer. Journal of AIDS 1990a: 3: 959-964.
17. Lopez-Anaya, A, Unadkat JD, Schumann LA and Smith AL. Pharmacokinetics of zidovudine (azidothymidine). II. Development of metabolic and renal clearance pathways in the neonate. Journal of AIDS 1990b; 3: 1052-1058.
18. Lopez-Anaya, A, Unadkat JD, Schumann LA and Smith AL. Pharmacokinetics of zidovudine (azidothymidine). III. Effect of pregnancy. Journal of AIDS 1991: 4: 64-68.
19. Mitsuya H, Yarchoan R, Broder S. Molecular targets of AIDS therapy. Science 1990; 249: 1533-1544.
20. Mofenson LM and McIntyre JA. Advances and research directions in the prevention of mother-to-child HIV-1 transmission. Lancet 2000; 355: 2237-2244.
21. Molema G, Jansen RW, Visser J and Meijer DK. Simultaneous analysis of azidothymidine and its mono-, di-, and triphosphate derivatives in biological fluids, tissue and cultures cells by a rapid high-performance liquid chromatographic method. Journal of Chromatography 1992; 579: 107-114.
22. Olivero OA, Parikka R, Poirier MC and Vähäkangas K. 3-Azido-3-deoxythymidine (AZT) transplacental perfusion kinetics and DNA incorporation in normal human placentas perfused with AZT. Mutation Research 1999; 428: 41-47.
23. O'Sullivan MJ, Boyer, PJ, Scott GB, Parks WP, Weller S, Blum R, Balsley J and Bryson, YJ. The pharmacokinetics and safety of zidovudine in the third trimester of pregnancy for women infected with human immunodeficiency virus and their infants: Phase I Acquired Immunodeficiency Syndrome Clinical Trials Group study (Protocol 082). American Journal of Obstetrics and Gynecology 1993; 168: 1510-1516.
24. Patterson TA, Binienda ZK, Lipe GW, Gillam MP and Slikker W. Transplacental pharmacokinetic and fetal distribution of azidothymidine, its glucuronide and phosphorylated metabolites in late-term rhesus macaques after maternal infusion. Drug Metabolism and Disposition 1997; 25: 453-459.
25. Peter K and Gambertoglio JG. Zidovudine phosphorylation after short-term and long-term therapy with zidovudine in patients infected with the human immunodeficiency virus. Clinical Pharmacology Therapy 1990; 60: 168-176.
26. Qian M, Bui T, Ho RJ and Unadkat JD. Metabolism of 3-azido-3-deoxythymidine (AZT) in human placental trophoblasts and Hofbauer cells. Biochemical Pharmacology 1994; 48: 383-389.
27. Row KH, Griest WH and Maskarinec MP. Separation of modified nucleic acid constituents by micellar electrokinetic capillary chromatography. Journal of Chromatography 1987; 409: 193-203.
28. Sandberg JA and Slikker W. Developmental pharmacology and toxicology of anti-HIV therapeutic agents: dideoxynucleosides. FASEB 1995; 9: 1157-1163.
29. Scott GB, Fischl MA, Klimas N, Fletcher MA, Dickinson GM, Levine RS and Parks WP. Mothers of infants with immunodeficiency syndrome. Evidence for symptomatic and asymptomatic carriers. JAMA 1985; 253: 363-366.
30. Singhal R, Xian J and Otim O. Application of spherical and other polymers in capillary zone electrophoresis: separation of antiviral drugs and deoxyribonucleoside phosphates by different principles. Journal of Chromatography A 1996; 756: 263-277.
31. Tadepalli SM, Puckett L, Jeal S, Kanics L and Quinn RP. Differential assay of zidovudine and its glucuronide metabolite in serum and urine with a radioimmunoassay kit. Clinical Chemistry 1990; 36: 897-900.
32. Tan X and Boudinot, FD. Simultaneous detrmination of zidovudine and its monophosphate in mouse plasma and peripheral red blood cells by high-performance liquid chromatography. Journal of Chromatography B 2000; 740: 281-287.
33. Törnevik Y, Jacobsson B, Britton S and Eriksson S. Intracellular metabolism of 3-azidothymidine in isolated human peripheral blood mononuclear cells. Aids Research, Human Retrovirus 1991; 7: 751-759.
34. Törnevik Y, Ullman B, Balzarini J, Wahren B and Eriksson S. Cytotoxicity of 3-azido-3-deoxythymidine correlates with 3-azidothymidine-5monophosphate (AZTMP) levels, whereas anti-HIV activity correlates with 3-azidothymidine-5-triphosphate (AZTTP) levels in cultured CEM T-lymphoblastoid cells. Biochemical Pharmacology 1995; 49: 829-837.
35. Toyoshima T, Kimura S, Muramatsu S, Takahagi H and Shimada K. A sensitive nonisotopic method for the determination of intracellular azidothymidine 5- mono-, 5-di-, and 5-triphosphate. Analytical Biochemistry 1991; 196: 302-307.
36. Unadkat JD, Crosby SS, Wang JP, Hertel, CC. Simple and rapid high-performance chromatographic assay for Zidoviudine (Azidothymidine) in plasma and urine. Journal of Chromatography 1988; 430: 420-423.
37. Watts DH, Brown AZ, Tartaglione T, Burchett SK, Opheim K, Coombs R and Corey L. Pharmacokinetic disposition of zidovudine during pregnancy. Journal of Infectious Disease 1991; 163: 226-232.