Normal expression of isoforms activating cyclic adenosine monophosphate responsive element modulator in patients with spermatid maturation arrest

Fertility and Sterility

Volumn 82, Issue SUPPL. 3, 2004, Pages 1072-1076

  Palermo, Irina ^a   Arcidiacono, Giuseppe ^b   Barone, Nunziata ^a   Italia, Fabrizio ^c   Arizzi, Mario ^d   Spera, Giovanni ^d   Bartoloni, Giovanni ^c   Di Mercurio, Silvana ^c   Vicari, Enzo ^a   Calogero, Aldo E ^a,e  

^a Section of Endocrinology   (Italy)

^b GARIBALDI HOSPITAL   (Italy)

^c UNIVERSITY OF CATANIA   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e Sezione di Endocrinologia   (Italy)

Author keywords

CREM; immunohistochemistry; Johnson's score; normal spermatogenesis; spermatid; spermatid maturation arrest; testicular biopsy

Indexed keywords

CYCLIC AMP;

ARTICLE; AZOOSPERMIA; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; HISTOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MALE INFERTILITY; MEDICAL ASSESSMENT; ONSET AGE; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SEXUAL MATURATION; SPERMATID; SPERMATOGENESIS; TESTIS BIOPSY;

BIOPSY; CELL AGING; CYCLIC AMP RESPONSE ELEMENT MODULATOR; DNA-BINDING PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; OLIGOSPERMIA; REPRESSOR PROTEINS; SPERMATIDS; TESTIS;

EID: 5044223231     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2004.05.077     Document Type: Article

References (23)

1. V. Delmas, F. van der Hoorn, B. Mellstrom, B. Jegou, P. Sassone-Corsi Induction of CREM activator proteins in spermatids: down-stream targets and implication for haploid germ cell differentiation Mol Endocrinol 7 1993 1502 1514
2. M.K. Kistler, P. Sassone-Corsi, S.W. Kistler Identification of a functional cAMP response element in the 5′-flanking region of the gene for transition protein 1 (TP1), a basic chromosomal protein of mammalian spermatids Biol Reprod 51 1994 1322 1329
3. Z. Sun, P. Sassone-Corsi, A. Means Calspermin gene transcription is regulated by two cyclic AMP response elements contained in an alternative promoter in the calmodulin kinase IV gene Mol Cell Biol 15 1995 561 571
4. E. Lalli, J.S. Lee, M. Lamas, K. Tamai, E. Zazopoulus, F Nantel The nuclear response to cAMP: role of transcription factor CREM Phil Trans R Soc Lond 351 1996 201 209
5. L. Monaco, F. Nantel, S.N. Foulkes, P. Sassone-Corsi CREM: a transcriptional master switch governing the cAMP response in the testis V. Hansson F.O. Levy K. Tsken Signal transduction in testicular cells 1996 Springer-Verlag Berlin 69 94
6. N.S. Foulkes, E. Borrelli, P. Sassone-Corsi CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription Cell 64 1991 739 749
7. N.S. Foulkes, B. Mellstrom, E. Benusiglio, P. Sassone-Corsi Developmental switch of CREM function during spermatogenesis: from antagonist to transcriptional activator Nature 355 1992 80 84
8. N.S. Foulkes, P. Sassone-Corsi More is better: activators and repressors from the same gene Cell 68 1992 411 414
9. B.M. Laoide, N.S. Foulkes, F. Schlotter, P. Sassone-Corsi The functional versatility of CREM is determined by its modular structure EMBO J 12 1993 1179 1191
10. P.B. Daniel, L. Rohrbach, J.F. Habener Novel cyclic adenosine 3′, 5′-monophosphate (cAMP) response element modulator theta isoforms expressed by the two newly identified cAMP-responsive promoters active in the testis Endocrinology 141 2000 3923 3930
11. V. Delmas, B. Laoide, D. Masquilier, R.P. de Groot, N.S. Foulkes, P. Sassone-Corsi Alternative usage of initiation codons in CREM generates regulators with opposite functions Proc Natl Acad Sci USA 89 1992 4226 4230
12. C.A. Molina, N.S. Foulkes, E. Lalli, P. Sassone-Corsi Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressor Cell 75 1993 875 886
13. J.A. Blendy, K.H. Kaestner, W. Schmid, P. Gass, G. Schutz Targeting of the CREB gene leads to up-regulation of a novel CREM mRNA isoform EMBO J 15 1996 1098 1106
14. F. Nantel, L. Monaco, N.S. Foulkes, D. Masquilier, M. LeMeur, K Henriksen Spermiogenesis deficiency and germ cell apoptosis in CREM-mutant mice Nature 380 1996 159 162
15. J.A. Blendy, K.H. Kaestner, G.F. Weibauer, E. Nieschlag, G. Schutz Severe impairment of spermatogenesis in mice lacking the CREM gene Nature 380 1996 162 165
16. G.F. Weinbauer, R. Behr, M. Bergmann, E. Nieschlag Testicular cAMP responsive element modulator (CREM) protein is expressed in round spermatids but is absent or reduced in men with round spermatid maturation arrest Mol Hum Reprod 4 1998 9 15
17. A. Peri, C. Krausz, F. Cioppi, S. Granchi, G. Forti, S Francavilla cAMP-responsive element modulator gene expression in germ cells of normo- and oligoazoospermic men J Clin Endocrinol Metab 83 1998 3722 3726
18. W.W. Lin, D.J. Lamb, L.I. Lipshultz, E.D. Kim Absence of cAMP responsive element modulator expression at the spermatocyte arrest stage Fertil Steril 69 1998 533 538
19. A.E. Calogero, M.R. Garofalo, N. Barone, A. De Palma, E. Vicari, R Romeo Spontaneous regression over time of the germinal epithelium in a Y chromosome-microdeleted patient Hum Reprod 16 2001 1845 1848
20. S.G. Johnsen Testicular biopsy score count - a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males Hormones 1 1970 2 25
21. Y. Clermont The cycle of the seminiferous epithelium in man Am J Anat 112 1963 35 46
22. A.F. Holstein, R.C. Roosen-Runge Atlas of human spermatogenesis 1981 Grosse-Verlag Berlin 224
23. European Association of Urology: Guidelines. Healthcare Office G.M. Colpi, T.B. Hargreave, G.K. Papp, J.M. Pomerol, W. Weidner European Association of Urology: guidelines on infertility 2001 Drukkerij Gelderland bv Arnhem, The Netherlands 1 57