A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism

Journal of Biological Chemistry

Volumn 283, Issue 28, 2008, Pages 19351-19358

  Chu, Lianrui ^a   Lai, Yanlai ^a   Xu, Xiaoping ^a   Eddy, Scott ^a   Yang, Shuang ^a   Song, Li ^a   Kolodrubetz, David ^b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b University of Texas Health Science Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; BIOCHEMISTRY; BIODEGRADATION; CALCIUM; CHROMATOGRAPHIC ANALYSIS; ELECTROSPRAY IONIZATION; ENZYMES; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN; HYDROGEN SULFIDE; IONIZATION OF LIQUIDS; LIQUID CHROMATOGRAPHY; MANGANESE; MANGANESE COMPOUNDS; MASS SPECTROMETRY; METABOLISM; ORGANIC ACIDS; PURIFICATION; ZINC;

AMINO ACID SEQUENCES; AMINO PEPTIDASES; CYSTEINYLGLYCINE; END PRODUCTS; ENZYME PATHWAYS; GENOME DATUMS; GLUTATHIONE; GLUTATHIONE METABOLISMS; HOST TISSUES; IN VITRO DEGRADATIONS; METALLO PROTEASES; NATIVE PROTEINS; SEQUENCE HOMOLOGIES; TANDEM MASS SPECTROMETRIES;

HIGH PRESSURE LIQUID CHROMATOGRAPHY;

BACTERIAL ENZYME; CALCIUM ION; COBALT; CYSTEINYLGLYCINASE; CYSTEINYLGLYCINE; CYTOSOL AMINOPEPTIDASE; GAMMA GLUTAMYLTRANSFERASE; HYDROGEN SULFIDE; MAGNESIUM ION; MANGANESE; UNCLASSIFIED DRUG; ZINC ION; BACTERIAL PROTEIN; CYSTEINYL GLYCINE DIPEPTIDASE; CYSTEINYL-GLYCINE DIPEPTIDASE; DIPEPTIDASE; DIPEPTIDE; GLUTATHIONE; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL GENOME; BACTERIAL KINETICS; BIOSYNTHESIS; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME PURIFICATION; ESCHERICHIA COLI; GENE OVEREXPRESSION; GLUTATHIONE METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MULTIGENE FAMILY; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; SEQUENCE HOMOLOGY; TANDEM MASS SPECTROMETRY; TREPONEMA DENTICOLA; CHEMISTRY; ENZYMOLOGY; GENETICS; HYDROLYSIS; METABOLISM; MICROBIOLOGY; PATHOGENICITY; PERIODONTITIS; PHYSIOLOGY;

ESCHERICHIA COLI; TREPONEMA DENTICOLA;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIPEPTIDASES; DIPEPTIDES; ESCHERICHIA COLI; GAMMA-GLUTAMYLTRANSFERASE; GENOME, BACTERIAL; GLUTATHIONE; HYDROGEN SULFIDE; HYDROLYSIS; LEUCYL AMINOPEPTIDASE; PERIODONTITIS; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TREPONEMA DENTICOLA;

EID: 50349095675     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801034200     Document Type: Article

References (51)

1. Persson, S., Claesson, R., and Carlsson, J. (1989) Oral Microbiol. Immunol. 4, 169-172
2. Claesson, R., Edlund, M. B., Persson, S., and Carlsson, J. (1990) Oral Microbiol. Immunol. 5, 137-142
3. Persson, S., Edlund, M. B., and Claesson, R. (1990) Oral Microbiol. Immunol. 5, 195-201
4. United States National Research Council (1979) Hydrogen Sulfide in Medical and Biologic Effects of Environmental Pollutants, pp. 1-50, University Park Press, Baltimore, MD
5. Beauchamp, R. O., Bus, J. S., Jr., Popp, J. A., Boreiko, C. J., and Andjelkovich, D. A. (1984) Crit. Rev. Toxicol. 13, 25-97
6. Reiffenstein, R. J., Hulbert, W. C., and Roth, S. H. (1992) Annu. Rev. Pharmacol. Toxicol. 32, 109-134
7. Morhart, R. E., Mata, L. J., Sinskey, A. J., and Harris, R. S. (1970) J. Periodontol. 41, 644-649
8. Horowitz, A., and Folke, L. E. (1973) J. Periodontal. 44, 390-395
9. Persson, S. (1992) Oral Microbiol. Immunol. 7, 378-379
10. Rizzo, A. A. (1967) Periodontics 5, 233-236
11. Carlsson, J., Larsen J. T., and Edlund, M. B. (1993) Oral Microbiol. Immunol. 8, 42-45
12. Chu, L., Dong, Z., Xu, X., Cappelli, D., and Ebersole, J. (2002) Infect. Immun. 70, 1113-11207
13. Simonson, L. G., Goodman, C. H., Bial, J. J., and Morton, H. E. (1988) Infect. Immun. 56, 726-728
14. Moore, W. E. C. (1987) J. Periodont. Ris. 22, 335-341
15. Aimetti, M., Romano, F., and Nessi, F. (2007) J. Periodontol. 78, 1718-1723
16. Sela, M. N. (2001) Crit. Rev. Oral Biol. Med. 12, 399-413
17. Holt, S. C., and Ebersole, J. L. (2005) Periodontol. 38, 72-122
18. Chu, L., Ebersole, J. L., Kurzben, G. P., and Holt, S. C. (1997) Infect. Immun. 65, 3231-3238
19. Chu, L., Xu, X., Dong, Z., Cappelli, D., and Ebersole, J. D. (2003) Infect. Immun. 71, 335-342
20. Chu, L., and Holt, S. C. (1994) Microb. Pathog. 16, 197-212
21. Chu, L., Burgum, A., Kolodrubetz, D., and Holt, S. C. (1995) Infect. Immun. 63, 4448-4455
22. Makinen, P. L., and Makinen, K. K. (1997) Infect. Immun. 65, 685-691
23. Chu, L., Ebersole, J. L., Kurzben, G. P., and Holt, S. C. (1999) Clin. Infect. Dis. 28, 442-450
24. Chu, L., Ebersole, J. L., and Holt, S. C. (1999) Oral Microbiol. Immunol. 14, 293-303
25. Kurzben, G. P., Chu, L., Ebersole, J. L., and Holt, S. C. (1999) Oral Microbiol. Immunol. 14, 153-164
26. Krupka, H. I., Huber, R., Holt, S. C., and Clausen, T. (2000) EMBO J. 19, 3168-3178
27. Bertoldi, M., Cellini, B., Clausen, T., and Voltattorni, C. B. (2002) Biochemistry 41, 9153-9164
28. Cellini, B., Bertoldi, M., Paiardini, A., D'Aguanno, S., and Voltattorni, C. B. (2004) J. Biol. Chem. 279, 36898-36905
29. Cellini, B., Bertoldi, M., Montioli, R., Laurents, D. V., Paiardini, A., and Voltattorni, C. B. (2006) Biochemistry 45, 14140-14154
30. Cellini, B., Montioli, R., Bossi, A., Bertoldi, M., Laurents, D. V., and Voltattorni, C. B. (2006) Arch. Biochem. Biophys. 455, 31-39
31. Seshadri, R., Myers, G. S., Tettelin, H., Eisen, J. A., Heidelberg, J. F., Dodson, R. J., Davidsen, T. M., DeBoy, R. T., Fouts, D. E., Haft, D. H., Selengut, J., Ren, Q., Brinkac, L. M., Madupu, R., Kolonay, J., Durkin, S. A., Daugherty, S. C., Shetty, J., Shvartsbeyn, A., Gebregeorgis, E., Geer, K., Tsegaye, G., Malek, J., Ayodeji, B., Shatsman, S., McLeod, M. P., Smajs, D., Howell, J. K., Pal, S., Amin, A., Vashisth, P., McNeill, T. Z., Xiang, Q., Sodergren, E., Baca, E., Weinstock, G. M., Norris, S. J., Fraser, C. M., and Paulsen, I. T. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 5646-5651
32. Weinberg, A., and Holt, S. C. (1990) Infect. Immun. 58, 1720-1729
33. Blakemore, R. P., and Canale-Parola, E. (1976) J. Bacteriol. 128, 616-622
34. Gaitonde, M. K. (1967) Biochem. J. 104, 627-633
35. Morty, R. E., and Morehead, J. (2002) J. Biol. Chem. 277, 26057-26065
36. Thomas, J. A., Hardies, S. C., Rolando, M., Hayes, S., Lieman, K., Carroll, C. A., Weintraub, S. T., and Serwer, P. (2007) Virology 368, 405-421
37. Siegel, L. M. (1965) Anal. Biochem. 11, 126-132
38. Zheng, L., White, R. H., Cash, V. L., Jack, R. F., and Dean, D. R. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 2754-2758
39. Bauer, J. D., Ackermann, P. G., and Toro, P. (1974) Clinical Laboratory Methods, pp. 399-401, The C. V. Mosby Company, St. Louis, MO
40. Chu, L., Kong, X., Shao, J., Lee, M., and Xie, J. (1986) Shanghai J. Immunol. 6, 243-248
41. nd Ed., pp. 905-908, Elsevier/Academic Press, San Diego, CA
42. nd Ed., pp. 896-899, Elsevier/Academic Press, San Diego, CA
43. Suzuki, H., Kamatani, S., Kim, E. S., and Kumagai, H. (2001) J. Bacteriol. 183, 1489-1490
44. Suzuki, H., Kamatani, S., and Kumagai, H. (2001) Biosci. Biotechnol. Biochem. 65, 1549-1558
45. Jösch, C., Klotz, L. O., and Sies, H. (2003) Biol. Chem. 384, 213-218
46. Cappiello, M., Lazzarotti, A., Buono, F., Scaloni, A., D'Ambrosio, C., Amodeo, P., Méndez, B. L., Pelosi, P., Del Corso, A., and Mura, U. (2004) Biochem. J. 378, 35-44
47. Cappiello, M., Cappiello, M., Alterio, V., Amodeo, P., Del Corso, A., Scaloni, A., Pedone, C., Moschini, R., De Donatis, G. M., De Simone, G., and Mura, U. (2006) Biochemistry 45, 3226-3234
48. Carlsson, J., Larsen, J. T., and Edlund, M. B. (1994) Oral Microbiol. Immunol. 9, 297-300
49. Tang-Larsen, J., Claesson, R., Edlund, M. B., and Carlsson, J. (1995) J. Periodont. Res. 30, 390-395
50. Dong, L., Cheng, N., Wang, M. W., Zhang, J., Shu, C., and Zhu, D. X. (2005) Microbiology 151, 2017-2023
51. Smirnova, G. V., and Oktyabrsky, O. N. (2005) Biochemistry (Moscow) 70, 1459-1473