AP-4: Autophagy-four mislocalized proteins in axons

Autophagy

Volumn 4, Issue 6, 2008, Pages 815-816

  Matsuda, Shinji ^a   Yuzaki, Michisuke ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Adaptor protein; AMPA receptors; Autophagy; Glutamate receptors; LC3; Neuron; Sorting; Trafficking

Indexed keywords

2 AMINO 4 PHOSPHONOBUTYRIC ACID; AMPA RECEPTOR; GLUTAMATE RECEPTOR 2; LOW DENSITY LIPOPROTEIN RECEPTOR; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ARTICLE; AUTOPHAGY; CELL SURFACE; EXPERIMENTAL MOUSE; NERVE FIBER; NONHUMAN; PROTEIN BINDING; PROTEIN STRUCTURE;

MUS; VERTEBRATA;

EID: 50249188180     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.6493     Document Type: Article

References (15)

1. Horton AC, Ehlers MD. Neuronal polarity and trafficking. Neuron 2003; 40:277-95.
2. Boehm M, Bonifacino JS. Adaptins: the final recount. Mol Biol Cell 2001; 12:2907-20.
3. Folsch H, Ohno H, Bonifacino JS, Mellman I. A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells. Cell 1999; 99:189-98.
4. Simmen T, Honing S, Icking A, Tikkanen R, Hunziker W. AP-4 binds basolateral signals and participates in basolateral sorting in epithelial MDCK cells. Nat Cell Biol 2002; 4:154-9.
5. Dotti CG, Simons K. Polarized sorting of viral glycoproteins to the axon and dendrites of hippocampal neurons in culture. Cell 1990; 62:63-72.
6. Jareb M, Banker G. The polarized sorting of membrane proteins expressed in cultured hippocampal neurons using viral vectors. Neuron 1998; 20:855-67.
7. Silverman MA, Peck R, Glover G, He C, Carlin C, Banker G. Motifs that mediate dendritic targeting in hippocampal neurons: a comparison with basolateral targeting signals. Mol Cell Neurosci 2005; 29:173-80.
8. Matsuda S, Miura E, Matsuda K, Kakegawa W, Kohda K, Watanabe M, Yuzaki M. Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP-4. Neuron 2008; 57:730-45.
9. Yap CC, Murate M, Kishigami S, Muto Y, Kishida H, Hashikawa T, Yano R. Adaptor protein complex-4 (AP-4) is expressed in the central nervous system neurons and interacts with glutamate receptor delta2. Mol Cell Neurosci 2003; 24:283-95.
10. Vandenberghe W, Nicoll RA, Bredt DS. Stargazin is an AMPA receptor auxiliary subunit. Proc Natl Acad Sci USA 2005; 102:485-90.
11. Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. Embo J 2000; 19:5720-8.
12. Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 2004; 15:1101-11.
13. Bjorkoy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, Stenmark H, Johansen T. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 2005; 171:603-14.
14. Martinez-Vicente M, Cuervo AM. Autophagy and neurodegenerarion: when the cleaning crew goes on strike. Lancet Neurol 2007; 6:352-61.
15. Wang QJ, Ding Y, Kohtz DS, Mizushima N, Cristea IM, Rout MP, Chait BT, Zhong Y, Heintz N, Yue Z. Induction of autophagy in axonal dystrophy and degeneration. J Neurosci 2006; 26:8057-68.