Towards the definition of a chimpanzee and human conserved CD6 domain 1 epitope recognized by T1 monoclonal antibody

Hybridoma

Volumn 27, Issue 4, 2008, Pages 291-301

  Alonso, Ruby ^a   Huerta, Vivian ^b   De Leon, Joel ^a   Piedra, Patricia ^a   Puchades, Yaquelin ^b   Guirola, Osmany ^b   Chinea, Glay ^b   Montero, Enrique ^a  

^a CENTER OF MOLECULAR IMMUNOLOGY   (Cuba)

^b CENTER FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Cuba)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; CD6 ANTIGEN; EPITOPE; MONOCLONAL ANTIBODY; PROTEIN INTERACTING WITH PROTEIN KINASE C;

ANIMAL CELL; ANTIBODY STRUCTURE; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL ACTIVATION; CELL ADHESION; CELL MATURATION; CELL SURVIVAL; CHIMPANZEE; CONFORMATION; CONTROLLED STUDY; EMBRYO; GLYCOSYLATION; HUMAN; HUMAN CELL; LYMPHOCYTE; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIGEN-ANTIBODY REACTIONS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CELLS, CULTURED; CONSERVED SEQUENCE; CROSS REACTIONS; EPITOPE MAPPING; EPITOPES; EPITOPES, T-LYMPHOCYTE; HUMANS; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PAN TROGLODYTES; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

MURINAE; PAN;

EID: 50249165877     PISSN: 15540014     EISSN: None     Source Type: Journal    
DOI: 10.1089/hyb.2008.0007     Document Type: Article

References (42)

1. Sarrias MR, Gronlund J, Padilla O, Madsen J, Holmskov U, and Lozano F: The Scavenger Receptor Cysteine-Rich (SRCR) domain: an ancient and highly conserved protein module of the innate immune system. Crit Rev Immunol 2004;24:1-37.
2. Kamoun M, Kadin ME, Martin PJ, Nettleton J, and Hansen JA: A novel human T cell antigen preferentially expressed on mature T cells and shared by both well and poorly differentiated B cell leukemias and lymphomas. J Immunol 1981;127:987-991.
3. Aruffo A, Melnick MB, Linsley PS, and Seed B: The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins. J Exp Med 1991;174:949-952.
4. Patel DD, Wee SF, Whichard LP, Bowen MA, Pesando JM, Aruffo A, and Haynes BF: Identification and characterization of a 100-kD ligand for CD6 on human thymic epithelial cells. J Exp Med 1995;181:1563-1568.
5. Hassan NJ, Barclay AN, and Brown MH: Frontline: Optimal T cell activation requires the engagement of CD6 and CD166. Eur J Immunol 2004;34:930-940.
6. Singer NG, Fox DA, Haqqi TM, Beretta L, Endres JS, Prohaska S, Parnes JR, Bromberg J, and Sramkoski RM: CD6: expression during development, apoptosis and selection of human and mouse thymocytes. Int Immunol 2002;14:585-597.
7. Bodian DL, Skonier JE, Bowen MA, Neubauer M, Siadak AW, Aruffo A, and Bajorath J: Identification of residues in CD6 which are critical for ligand binding. Biochemistry 1997;36:2637-2641.
8. Whitney GS, Starling GC, Bowen MA, Modrell B, Siadak AW, and Aruffo A: The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site. J Biol Chem 1995;270:18187-18190.
9. Cayrol R, Wosik K, Berard JL, Dodelet-Devillers A, Ifergan I, Kebir H, Haqqani AS, Kreymborg K, Krug S, Moumdjian R, Bouthillier A, Becher B, Arbour N, David S, Stanimirovic D, and Prat A: Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system. Nat Immunol 2008;9:137-145.
10. Starling GC, Siadak AW, Bowen MA, Aruffo A, Bajorath J, Bodian DL, and Skonier JE: Monoclonal Antibodies to Human CD6. Bristol-Mayer Squibb Company, San Diego, 2002, pp. 44-79.
11. Bott CM, Doshi JB, Morimoto C, Romain PL, and Fox DA: Activation of human T cells through CD6: functional effects of a novel anti-CD6 monoclonal antibody and definition of four epitopes of the CD6 glycoprotein. Int Immunol 1993;5:783-792.
12. Gangemi RM, Swack JA, Gaviria DM, and Romain PL: Anti-T12, an anti-CD6 monoclonal antibody, can activate human T lymphocytes. J Immunol 1989;143:2439-2447.
13. Swack JA, Gangemi RM, Rudd CE, Morimoto C, Schlossman SF, and Romain PL: Structural characterization of CD6: properties of two distinct epitopes involved in T cell activation. Mol Immunol 1989;26:1037-1049.
14. Gavilondo J, Garcia CA, Fernandez A, Vazquez A, Amador JF, Cabrera L, and Hernandez S: Obtención de anticuerpos monoclonales anti-T. Rev Cubana Oncol 1985;1:1008-1016.
15. Mateo C, Lombardero J, Moreno E, Morales A, Bombino G, Coloma J, Wims L, Morrison SL, and Perez R: Removal of amphipathic epitopes from genetically engineered antibodies: production of modified immunoglobulins with reduced immunogenicity. Hybridoma 2000;19:463-471.
16. Roque-Navarro L, Mateo C, Lombardero J, Mustelier G, Fernandez A, Sosa K, Morrison SL, and Perez R: Humanization of predicted T-cell epitopes reduces the immunogenicity of chimeric antibodies: new evidence supporting a simple method. Hybrid Hybridomics 2003;22:245-257.
17. Garcia CA, Faxas ME, Gavilondo J, Amador JF, and Exposito G: Topical treatment of cutaneous T cell lymphoma skin lesion with the mouse anti-CD6 antibody ior t1. Biotecnología Aplicada 1990;7:176-181.
18. Montero E, Falcon L, Morera Y, Delgado J, Amador JF, and Perez R: CD6 molecule may be important in the pathological mechanisms of lymphocytes adhesion to human skin in psoriasis and ior t1 MAb a possible new approach to treat this disease. Autoimmunity 1999;29:155-156.
19. Tormo BR, Garcia CA, Chong A, Ochoa C, Faxas ME, Sagaro B, and Biberfeld P: Immunohistophatology of cutaneous T-cell lymphomas treated with topic ior t1 (anti-CD6) monoclonal antibody. Biotecnol Aplicada 1994;11:20-24.
20. Bayer EA, and Wilchek M: The use of the avidin-biotin complex as a tool in molecular biology. Methods Biochem Anal 1980;26:1-45.
21. Andrew SM, and Titus JA: Fragmentation of immunoglobulins G. In: Current Protocols in Immunology. Colligan JE, Kruisbeek AM, Margulies DH, Shevach EM, and Strober W (Eds.). Wiley, New York, 1997, pp. 1-10.
22. Heukeshoven J, and Dernick R: Improved silver staining procedure for fast staining in PhastSystem development unit. I. Staining of sodium dodecyl sulfate gels. Electrophoresis 1988;9:28-32.
23. Felici F, Castagnoli L, Musacchio A, Jappelli R, and Cesareni G: Selection of antibody ligands from a large library of oligopeptides expressed on a multivalent exposition vector. J Mol Biol 1991;222:301-310.
24. Parmley SF, and Smith GP: Antibody-selectable filamentous fd phage vectors: affinity purification of target genes. Gene 1988;73:305-318.
25. Sanger F, Nicklen S, and Coulson AR: DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 1977;74:5463-5467.
26. Sali A, and Blundell TL: Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol 1993;234:779-815.
27. Vriend G: WHAT IF: a molecular modeling and drug design program. J Mol Graph 1990;8:52-56,29.
28. Hall TA: BioEdit: a user-friendly biological secuence alignment editor and analysis program for Windows. Nucleic Acids Symp 1999;41:95-98.
29. Bowen MA, Bajorath J, D'Egidio M, Whitney GS, Palmer D, Kobarg J, Starling GC, Siadak AW, and Aruffo A: Characterization of mouse ALCAM (CD166): the CD6-binding domain is conserved in different homologs and mediates cross-species binding. Eur J Immunol 1997;27:1469-1478.
30. Bowen MA, Bajorath J, Siadak AW, Modrell B, Malacko AR, Marquardt H, Nadler SG, and Aruffo A: The amino-terminal immunoglobulin-like domain of activated leukocyte cell adhesion molecule binds specifically to the membrane-proximal scavenger receptor cysteine-rich domain of CD6 with a 1:1 stoichiometry. J Biol Chem 1996;271:17390-17396.
31. Laursen HB, Jorgensen AL, Jones C, and Bak AL: Higher rate of evolution of X chromosome alpha-repeat DNA in human than in the great apes. Embo J 1992;11:2367-2372.
32. Swack JA, Mier JW, Romain PL, Hull SR, and Rudd CE: Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule. J Biol Chem 1991;266:7137-7143.
33. Hohenester E, Sasaki T, and Timpl R: Crystal structure of a scavenger receptor cysteine-rich domain sheds light on an ancient superfamily. Nat Struct Biol 1999;6:228-232.
34. Gimferrer I, Calvo M, Mittelbrunn M, Farnos M, Sarrias MR, Enrich C, Vives J, Sanchez-Madrid F, and Lozano F: Relevance of CD6-mediated interactions in T cell activation and proliferation. J Immunol 2004;173:2262-2270.
35. Gimferrer I, Farnos M, Calvo M, Mittelbrunn M, Enrich C, Sanchez-Madrid F, Vives J, and Lozano F: The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells. J Biol Chem 2003;278:8564-8571.
36. Hafler DA, Fallis RJ, Dawson DM, Schlossman SF, Reinherz EL, and Weiner HL: Immunologic responses of progressive multiple sclerosis patients treated with an anti-T-cell monoclonal antibody, anti-T12. Neurology 1986;36:777-784.
37. Kirkman RL, Araujo JL, Busch GJ, Carpenter CB, Milford EL, Reinherz EL, Schlossman SF, Strom TB, and Tilney NL: Treatment of acute renal allograft rejection with monoclonal anti-T12 antibody. Transplantation 1983;36:620-626.
38. Reinherz EL, Geha R, Rappeport JM, Wilson M, Penta AC, Hussey RE, Fitzgerald KA, Daley JF, Levine H, Rosen FS, and Schlossman SF: Reconstitution after transplantation with T-lymphocyte-depleted HLA haplotype-mismatched bone marrow for severe combined immunodeficiency. Proc Natl Acad Sci USA 1982;79:6047-6051.
39. Osorio LM, Garcia CA, Jondal M, and Chow SC: The anti-CD6 mAb, IOR-T1, defined a new epitope on the human CD6 molecule that induces greater responsiveness in T cell receptor/CD3-mediated T cell proliferation. Cell Immunol 1994;154:123-133.
40. Joo YS, Singer NG, Endres JL, Sarkar S, Kinne RW, Marks RM, and Fox DA: Evidence for the expression of a second CD6 ligand by synovial fibroblasts. Arthritis Rheum 2000;43:329-335.
41. Saifullah MK, Fox DA, Sarkar S, Abidi SM, Endres J, Piktel J, Haqqi TM, and Singer NG: Expression and characterization of a novel CD6 ligand in cells derived from joint and epithelial tissues. J Immunol 2004;173:6125-6133.
42. Sarrias MR, Farnos M, Mota R, Sanchez-Barbero F, Ibañez A, Gimferrer I, Vera J, Fenutria R, Casals C, Yelamos J, and Lozano F: CD6 binds to phatogen-associated molecular patterns and protects from LPS-induced septic shock. Proc Natl Acad Sci USA 2007;104:11724-11729.