Aromatization of androstenedione and 16α-hydroxyandrostenedione in human placental microsomes. Kinetic analysis of inhibition by the 19-oxygenated and 3-deoxy analogs

Steroids

Volumn 73, Issue 12, 2008, Pages 1262-1269

  Numazawa, Mitsuteru ^a   Watari, Yoko ^a   Komatsu, Sachiko ^a   Yamashita, Kouwa ^a   Nagaoka, Masao ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

16 Hydroxyandrostenedione; Androstenedione; Aromatase; Biochemical aromatization; Substrate binding site

Indexed keywords

16ALPHA BROMANDROST 4 ENE 17,19 DIONE; 16ALPHA BROMO 19 HYDROXYANDROST 4 EN 17 ONE; 16ALPHA BROMOANDROST 4 ENE 17 ONE; 16ALPHA HYDROXYANDROS 4 EN 17 ONE; 16ALPHA HYDROXYANDROST 4 ENE 17,19 DIONE; 16ALPHA HYDROXYANDROSTENEDIONE; 16ALPHA,19 DIHYDROXYANDROST 4 EN 17 ONE; [1BETA 3 H]16ALPHA HYDROXYANDROSTENEDIONE; ANDROST 4 ENE 16ALPHA,17BETA,19 TRIOL; ANDROSTE 4 ENE 16ALPHA,17BETA DIOL; ANDROSTENEDIONE; ANDROSTENEDIONE DERIVATIVE; AROMATASE; AROMATASE INHIBITOR; BROMOKETONE; KETONE DERIVATIVE; UNCLASSIFIED DRUG; 16 HYDROXYANDROST 4 EN 3,17 DIONE; 16-HYDROXYANDROST-4-EN-3,17-DIONE; DRUG DERIVATIVE; OXYGEN;

AROMATIZATION; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; KINETICS; MICROSOME; PLACENTA; CHEMISTRY; CYCLIZATION; FEMALE; INFRARED SPECTROSCOPY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANDROSTENEDIONE; AROMATASE INHIBITORS; CYCLIZATION; FEMALE; HUMANS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSOMES; OXYGEN; PLACENTA; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 50249162480     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2008.06.001     Document Type: Article

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