Associations of SNAP-25 polymorphisms with cognitive dysfunctions in Caucasian patients with schizophrenia during a brief trail of treatment with atypical antipsychotics

European Archives of Psychiatry and Clinical Neuroscience

Volumn 258, Issue 6, 2008, Pages 335-344

  Spellmann, Ilja ^a   Müller, Norbert ^a   Musil, Richard ^a   Zill, Peter ^a   Douhet, Anette ^a   Dehning, Sandra ^a   Cerovecki, Anja ^a   Bondy, Brigitta ^a   Möller, Hans Jürgen ^a   Riedel, Michael ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Atypical antipsychotics; Cognitive improvement; Executive function; Schizophrenia; SNAP 25

Indexed keywords

ARIPIPRAZOLE; ATYPICAL ANTIPSYCHOTIC AGENT; BIPERIDEN; CITALOPRAM; LORAZEPAM; MIRTAZAPINE; OLANZAPINE; QUETIAPINE; RISPERIDONE; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; ZOPICLONE;

3' UNTRANSLATED REGION; ADULT; AGED; ARTICLE; CAUCASIAN; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG DOSE TITRATION; EXTRAPYRAMIDAL SYNDROME; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENOTYPE; HUMAN; INSOMNIA; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; NEUROPSYCHOLOGICAL TEST; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT RESPONSE; VERBAL MEMORY; VISUAL MEMORY; WORKING MEMORY;

ADMINISTRATION, ORAL; ADULT; ALLELES; ANTIPSYCHOTIC AGENTS; ATTENTION; COGNITION; DOUBLE-BLIND METHOD; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; MEMORY; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PSYCHIATRIC STATUS RATING SCALES; REACTION TIME; SCHIZOPHRENIA; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25; VERBAL LEARNING; YOUNG ADULT;

EID: 50249147927     PISSN: 09401334     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00406-007-0800-9     Document Type: Article

References (70)

1. M Albus W Hubmann F Mohr S Hecht P Hinterberger-Weber NN Seitz H Kuchenhoff 2006 Neurocognitive functioning in patients with first-episode schizophrenia: results of a prospective 5-year follow-up study Eur Arch Psychiatry Clin Neurosci 256 442 451
2. SM Bajjalieh RH Scheller 1995 The biochemistry of neurotransmitter secretion J Biol Chem 270 1971 1974
3. AM Barr CE Young AG Phillips WG Honer 2006 Selective effects of typical antipsychotic drugs on SNAP-25 and synaptophysin in the hippocampal trisynaptic pathway Int J Neuropsychopharmacol 9 457 463
4. CL Barr Y Feng K Wigg S Bloom W Roberts M Malone R Schachar R Tannock JL Kennedy 2000 Identification of DNA variants in the SNAP-25 gene and linkage study of these polymorphisms and attention-deficit hyperactivity disorder Mol Psychiatry 5 405 409
5. RM Bilder RS Goldman J Volavka P Czobor M Hoptman B Sheitman JP Lindenmayer L Citrome J McEvoy M Kunz M Chakos TB Cooper TL Horowitz JA Lieberman 2002 Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorder Am J Psychiatry 159 1018 1028
6. Bleuler E (1950) Dementia Praecox for the Group of Schizophrenias. In: Zinkin J (ed) International University Press, New York
7. K Brophy Z Hawi A Kirley M Fitzgerald M Gill 2002 Synaptosomal-associated protein 25 (SNAP-25) and attention deficit hyperactivity disorder (ADHD): evidence of linkage and association in the Irish population Mol Psychiatry 7 913 917
8. KE Burdick JF Goldberg M Harrow RN Faull AK Malhotra 2006 Neurocognition as a stable endophenotype in bipolar disorder and schizophrenia J Nerv Ment Dis 194 255 260
9. KE Burdick TE Goldberg B Funke JA Bates T Lencz R Kucherlapati AK Malhotra 2007 DTNBP1 genotype influences cognitive decline in schizophrenia Schizophr Res 89 169 172
10. F Dudbridge 2003 A survey of current software for linkage analysis Hum Genomics 1 63 65
11. MF Egan TE Goldberg BS Kolachana JH Callicott CM Mazzanti RE Straub D Goldman DR Weinberger 2001 Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia Proc Natl Acad Sci USA 98 6917 6922
12. L Erlenmeyer-Kimling BA Cornblatt D Rock S Roberts M Bell A West 1993 The New York high-risk project: anhedonia, attentional deviance, and psychopathology Schizophr Bull 19 141 153
13. JM Gold C Carpenter C Randolph TE Goldberg DR Weinberger 1997 Auditory working memory and Wisconsin card sorting test performance in schizophrenia Arch Gen Psychiatry 54 159 165
14. TE Goldberg RE Straub JH Callicott A Hariri VS Mattay L Bigelow R Coppola MF Egan DR Weinberger 2006 The G72/G30 gene complex and cognitive abnormalities in schizophrenia Neuropsychopharmacology 31 2022 2032
15. C Gonzalez-Blanch M varez-Jimenez JM Rodriguez-Sanchez R Perez-Iglesias JL Vazquez-Barquero B Crespo-Facorro 2006 Cognitive functioning in the early course of first-episode schizophrenia spectrum disorders: timing and patterns Eur Arch Psychiatry Clin Neurosci 256 364 371
16. MF Gosso EJ de Geus MJ van Belzen TJ Polderman P Heutink DI Boomsma D Posthuma 2006 The SNAP-25 gene is associated with cognitive ability: evidence from a family-based study in two independent Dutch cohorts Mol Psychiatry 11 878 886
17. MF Green BD Marshall Jr WC Wirshing D Ames SR Marder S McGurk RS Kern J Mintz 1997 Does risperidone improve verbal working memory in treatment-resistant schizophrenia? Am J Psychiatry 154 799 804
18. K Gutbrod R Cohen B Mager E Meier 1989 Coding and recall of categorized material in aphasics J Clin Exp Neuropsychol 11 821 841
19. ND Halim CS Weickert BW McClintock TM Hyde DR Weinberger JE Kleinman BK Lipska 2003 Presynaptic proteins in the prefrontal cortex of patients with schizophrenia and rats with abnormal prefrontal development Mol Psychiatry 8 797 810
20. PJ Harrison DR Weinberger 2005 Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence Mol Psychiatry 10 40 68
21. KA Hawkins 1999 Memory deficits in patients with schizophrenia: preliminary data from the Wechsler memory scale-third edition support earlier findings J Psychiatry Neurosci 24 341 347
22. RK Heaton JA Gladsjo BW Palmer J Kuck TD Marcotte DV Jeste 2001 Stability and course of neuropsychological deficits in schizophrenia Arch Gen Psychiatry 58 24 32
23. EJ Hess KA Collins NG Copeland NA Jenkins MC Wilson 1994 Deletion map of the coloboma (Cm) locus on mouse chromosome 2 Genomics 21 257 261
24. CJ Heyser MC Wilson LH Gold 1995 Coloboma hyperactive mutant exhibits delayed neurobehavioral developmental milestones Brain Res Dev Brain Res 89 264 269
25. WG Honer P Falkai C Young T Wang J Xie J Bonner L Hu GL Boulianne Z Luo WS Trimble 1997 Cingulate cortex synaptic terminal proteins and neural cell adhesion molecule in schizophrenia Neuroscience 78 99 110
26. J Horacek V Bubenikova-Valesova M Kopecek T Palenicek C Dockery P Mohr C Hoschl 2006 Mechanism of action of atypical antipsychotic drugs and the neurobiology of schizophrenia CNS Drugs 20 389 409
27. CN Karson RE Mrak KO Schluterman WQ Sturner JG Sheng WS Griffin 1999 Alterations in synaptic proteins and their encoding mRNAs in prefrontal cortex in schizophrenia: a possible neurochemical basis for "hypofrontality" Mol Psychiatry 4 39 45
28. RS Keefe SE Roitman PD Harvey CS Blum RL DuPre DM Prieto M Davidson KL Davis 1995 A pen-and-paper human analogue of a monkey prefrontal cortex activation task: spatial working memory in patients with schizophrenia Schizophr Res 17 25 33
29. RS Keefe LJ Seidman BK Christensen RM Hamer T Sharma MM Sitskoorn RR Lewine DA Yurgelun-Todd RC Gur M Tohen GD Tollefson TM Sanger JA Lieberman 2004 Comparative effect of atypical and conventional antipsychotic drugs on neurocognition in first-episode psychosis: a randomized, double-blind trial of olanzapine versus low doses of haloperidol Am J Psychiatry 161 985 995
30. RS Keefe JA Sweeney H Gu RM Hamer DO Perkins JP McEvoy JA Lieberman 2007 Effects of olanzapine, quetiapine, and risperidone on neurocognitive function in early psychosis: a randomized, double-blind 52-week comparison Am J Psychiatry 164 1061 1071
31. RS Kern MF Green BA Cornblatt JR Owen RD McQuade WH Carson M Ali R Marcus 2006 The neurocognitive effects of aripiprazole: an open-label comparison with olanzapine Psychopharmacology (Berl) 187 312 320
32. J Kornhuber A Schultz J Wiltfang I Meineke CH Gleiter R Zochling KW Boissl F Leblhuber P Riederer 1999 Persistence of haloperidol in human brain tissue Am J Psychiatry 156 885 890
33. Kraepelin E (1919) Dementia Praecox and Paraphrenia. In: Barclay RM, Robertson GM (eds) Lifingstone, Edinborough
34. V Kustanovich B Merriman J McGough JT McCracken SL Smalley SF Nelson 2003 Biased paternal transmission of SNAP-25 risk alleles in attention-deficit hyperactivity disorder Mol Psychiatry 8 309 315
35. Lehrl S (1977) Mehrfachwahl-Wortschatz-Intelligenztest. Manual zum MWT-B. Manual zum MWT-B. Straube, Erlangen
36. R Lewis 2004 Should cognitive deficit be a diagnostic criterion for schizophrenia? J Psychiatry Neurosci 29 102 113
37. HY Meltzer 2004 Cognitive factors in schizophrenia: causes, impact, and treatment CNS Spectr 9 15 24
38. HY Meltzer SR McGurk 1999 The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia Schizophr Bull 25 233 255
39. S Moritz TS Woodward M Krausz D Naber 2002 Relationship between neuroleptic dosage and subjective cognitive dysfunction in schizophrenic patients treated with either conventional or atypical neuroleptic medication Int Clin Psychopharmacol 17 41 44
40. M Morrens E Wezenberg RJ Verkes W Hulstijn GS Ruigt BG Sabbe 2007 Psychomotor and memory effects of haloperidol, olanzapine, and paroxetine in healthy subjects after short-term administration J Clin Psychopharmacol 27 15 21
41. EB Mukaetova-Ladinska J Hurt WG Honer CR Harrington CM Wischik 2002 Loss of synaptic but not cytoskeletal proteins in the cerebellum of chronic schizophrenics Neurosci Lett 317 161 165
42. DJ Muller TA Klempan LV De T Sicard J Volavka P Czobor BB Sheitman JP Lindenmayer L Citrome JP McEvoy JA Lieberman WG Honer JL Kennedy 2005 The SNAP-25 gene may be associated with clinical response and weight gain in antipsychotic treatment of schizophrenia Neurosci Lett 379 81 89
43. N Muller M Schwarz 2006 Schizophrenia as an inflammation-mediated dysbalance of glutamatergic neurotransmission Neurotox Res 10 131 148
44. T Nakahara K Nakamura T Tsutsumi K Hashimoto H Hondo S Hisatomi K Motomura H Uchimura 1998 Effect of chronic haloperidol treatment on synaptic protein mRNAs in the rat brain Brain Res Mol Brain Res 61 238 242
45. KH Nuechterlein ME Dawson MF Green 1994 Information-processing abnormalities as neuropsychological vulnerability indicators for schizophrenia Acta Psychiatr Scand Suppl 384 71 79
46. GA Oyler GA Higgins RA Hart E Battenberg M Billingsley FE Bloom MC Wilson 1989 The identification of a novel synaptosomal-associated protein, SNAP-25, differentially expressed by neuronal subpopulations J Cell Biol 109 3039 3052
47. BW Palmer RK Heaton JS Paulsen J Kuck D Braff MJ Harris S Zisook DV Jeste 1997 Is it possible to be schizophrenic yet neuropsychologically normal? Neuropsychology 11 437 446
48. J Peuskens C Demily F Thibaut 2005 Treatment of cognitive dysfunction in schizophrenia Clin Ther 27 Suppl A 25 37
49. JL Rapoport AM Addington S Frangou MR Psych 2005 The neurodevelopmental model of schizophrenia: update 2005 Mol Psychiatry 10 434 449
50. JL Reilly MS Harris MS Keshavan JA Sweeney 2006 Adverse effects of risperidone on spatial working memory in first-episode schizophrenia Arch Gen Psychiatry 63 1189 1197
51. RM Reitan 1958 Validity of the trailmaking test as an indication of organic brain damage Percept Mot Skills 8 271 276
52. Rey A (1958) Ĺexamen clinique en psychologie. Presse Universitaire de France, Paris
53. M Riedel I Spellmann M Strassnig A Douhet S Dehning M Opgen-Rhein R Valdevit RR Engel N Kleindienst N Mueller HJ Moeller 2007 Effects of Risperidone and Quetiapine on cognition in patients with schizophrenia and predominantly negative symptoms Eur Arch Psychiatry Clin Neurosci 257 6 360 370
54. Riedel M, Muller N, Spellmann I, Engel RR, Musil R, Valdevit R, Dehning S, Douhet A, Cerovecki A, Strassnig M, Moller HJ (2007) Efficacy of olanzapine versus quetiapine on cognitive dysfunctions in patients with an acute episode of schizophrenia. Eur Arch Psychiatry Clin Neurosci
55. JC Ruiz MJ Soler I Fuentes P Tomas 2007 Intellectual functioning and memory deficits in schizophrenia Compr Psychiatry 48 276 282
56. JK Rybakowski A Borkowska M Skibinska A Szczepankiewicz P Kapelski A Leszczynska-Rodziewicz PM Czerski J Hauser 2006 Prefrontal cognition in schizophrenia and bipolar illness in relation to Val66Met polymorphism of the brain-derived neurotrophic factor gene Psychiatry Clin Neurosci 60 70 76
57. K Sawada CE Young AM Barr K Longworth S Takahashi V Arango JJ Mann AJ Dwork P Falkai AG Phillips WG Honer 2002 Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illness Mol Psychiatry 7 484 492
58. BE Snitz AW Macdonald III CS Carter 2006 Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes Schizophr Bull 32 179 194
59. T Sollner SW Whiteheart M Brunner H Erdjument-Bromage S Geromanos P Tempst JE Rothman 1993 SNAP receptors implicated in vesicle targeting and fusion Nature 362 318 324
60. O Spreen AL Benton 1965 Comparative studies of some psychological tests for cerebral damage J Nerv Ment Dis 140 323 333
61. P Thoma B Wiebel I Daum 2007 Response inhibition and cognitive flexibility in schizophrenia with and without comorbid substance use disorder Schizophr Res 92 168 180
62. PM Thompson S Egbufoama MP Vawter 2003 SNAP-25 reduction in the hippocampus of patients with schizophrenia Prog Neuropsychopharmacol Biol Psychiatry 27 411 417
63. PM Thompson M Kelley J Yao G Tsai DP van Kammen 2003 Elevated cerebrospinal fluid SNAP-25 in schizophrenia Biol Psychiatry 53 1132 1137
64. DI Velligan TJ Prihoda D Sui JL Ritch N Maples AL Miller 2003 The effectiveness of quetiapine versus conventional antipsychotics in improving cognitive and functional outcomes in standard treatment settings J Clin Psychiatry 64 524 531
65. M Wagner BB Quednow J Westheide TE Schlaepfer W Maier KU Kuhn 2005 Cognitive improvement in schizophrenic patients does not require a serotonergic mechanism: randomized controlled trial of olanzapine vs amisulpride Neuropsychopharmacology 30 381 390
66. A Watanabe T Kato 2004 Cerebrovascular response to cognitive tasks in patients with schizophrenia measured by near-infrared spectroscopy Schizophr Bull 30 435 444
67. Wechsler D (1986) Wechsler Intelligence Scale for Childre-Revised (WISC-R)
68. Wiebel B, Happe A, Piekara FH (1995) Das neuropsychologische Diagnostikprogramm TESTBAT
69. AH Wong F Macciardi T Klempan W Kawczynski CL Barr S Lakatoo M Wong C Buckle J Trakalo E Boffa J Oak MH Azevedo A Dourado I Coelho A Macedo A Vicente J Valente CP Ferreira MT Pato CN Pato JL Kennedy HH Van Tol 2003 Identification of candidate genes for psychosis in rat models, and possible association between schizophrenia and the 14-3-3eta gene Mol Psychiatry 8 156 166
70. P Zuffante CM Leonard JM Kuldau RM Bauer EG Doty RM Bilder 2001 Working memory deficits in schizophrenia are not necessarily specific or associated with MRI-based estimates of area 46 volumes Psychiatry Res 108 187 209