Promoter hypermethylation and loss of heterozygosity of the APC gene in patients with familial adenomatous polyposis

Chinese Journal of Medical Genetics

Volumn 25, Issue 4, 2008, Pages 378-381

  Zhang, Yuan Ying ^a   Chen, Sen Qing ^a   Zhu, Ming ^a   Li, Jin Tian ^a   Ma, Guo Jian ^a   Zhang, Xiao Mei ^a   Zhou, Jian Nong ^a  

^a JIANGSU CANCER HOSPITAL   (China)

Author keywords

Adenomatus polyposis coli gene; Familial adenomatous polyposis; Loss of heterozygosity; Methylation; Methylation specific PCR

Indexed keywords

ADENOMATOUS POLYP; ADENOMATOUS POLYPOSIS COLI GENE; ARTICLE; CANCER TISSUE; CHROMOSOME ABERRATION; CLINICAL ARTICLE; DNA EXTRACTION; DNA SEQUENCE; FAMILIAL ADENOMATOUS POLYP; FAMILIAL POLYPOSIS; GENE AMPLIFICATION; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; HYPERMETHYLATION; METHYLATION; MULTIPLEX LIGATION DEPENDENT PROBE AMPLIFICATION; PEDIGREE; POLYMERASE CHAIN REACTION; PROMOTER REGION;

ADENOMATOUS POLYPOSIS COLI; ADENOMATOUS POLYPOSIS COLI PROTEIN; ADULT; BASE SEQUENCE; COLORECTAL NEOPLASMS; CPG ISLANDS; DNA METHYLATION; DNA, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, APC; HETEROZYGOTE; HUMANS; LOSS OF HETEROZYGOSITY; MALE; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC;

EID: 50249105303     PISSN: 10039406     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. O'Sullivan MJ, McCarthy TV, Doyle CT. Familial adenomatous polyposis : from bedside to benchside. Am J Clin Pathol, 1998, 109:521-526.
2. Esteller M, Sparks A, Toyota M, et al. Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer. Cancer Res, 2000, 60:4366-4371.
3. Sieber OM, Lamlum H, Crabtree MD, et al . Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas. Proc Natl Acad Sci U S A, 2002, 99:2954-2958.
4. Schouten JP, McElgunn CJ, Waaijer R, et al. Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification. Nucleic Acids Res, 2002, 30:e57.
5. Zhou JN, Chen SQ, Zhang XM, et al. A novel APC gene germLine mutation in a familial adenomatous polyposis pedigree. Chin J Med Genet, 2006, 23:388-391.
6. Yuan Y, Mendez R, Sahin A, et al. Hypermethylation leads to silencing of the SYK gene in human breast cancer. Cancer Res, 2001, 61:5558-5561.
7. Polakis P. The adenomatous polyposis coli (APC) tumor suppressor. Biochim Biophys Acta, 1997, 1332:127-147.
8. Knudson AG. Two genetic hits (more or less) to cancer. Nat Rev Cancer, 2001, 1:157-162.
9. Michils G, Tejpar S, Thoelen R, et al. Large deletions of the APC gene in 15% of mutation-negative patients with classical polyposis (FAP): a Belgian study. Hum Mutat, 2005, 25:125-134.
10. Segditsas S, Tomlinson I. Colorectal cancer and genetic alterations in the Wnt pathway. Oncogene, 2006, 25:7531-7537.