The primary, secondary, catastrophic, and seronegative variants of the antiphospholipid syndrome: A personal history long in the making

Seminars in Thrombosis and Hemostasis

Volumn 34, Issue 3, 2008, Pages 227-235

  Asherson, Ronald A ^a,b  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b Netcare   (South Africa)

Author keywords

CAPS; Catastrophic antiphospholipid (Asherson's) syndrome; PAPS; Primary antiphospholipid syndrome; Seronegative antiphospholipid syndrome; SNAPS

Indexed keywords

ANTINUCLEAR ANTIBODY; BLOOD CLOTTING FACTOR 5 LEIDEN; CARDIOLIPIN ANTIBODY; CELL NUCLEUS ANTIGEN; DOUBLE STRANDED DNA; ETHOSUXIMIDE; IMMUNOGLOBULIN M; LIPOCORTIN 5; LUPUS ANTICOAGULANT; NUCLEOSOME ANTIBODY; ORAL CONTRACEPTIVE AGENT; PHENOTHIAZINE; PHOSPHOLIPID ANTIBODY; PROCAINAMIDE; SINGLE STRANDED DNA; THIAZIDE DIURETIC AGENT;

ADULT RESPIRATORY DISTRESS SYNDROME; ANTIBODY TITER; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; ASHERSON SYNDROME; AUTOIMMUNE DISEASE; BLOOD CLOTTING DISORDER; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DISEASE ASSOCIATION; DISSEMINATED INTRAVASCULAR CLOTTING; DOUBLE STRANDED DNA BREAK; DRUG INDUCED DISEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FETUS WASTAGE; GANGRENE; HELLP SYNDROME; HUMAN; NEOPLASM; PRIORITY JOURNAL; PROGNOSIS; PROTEIN C DEFICIENCY; PROTEIN S DEFICIENCY; RHEUMATIC DISEASE; SECONDARY ANTIPHOSPHOLIPID SYNDROME; SERONEGATIVE ANTIPHOSPHOLIPID SYNDROME; SJOEGREN SYNDROME; SNEDDON SYNDROME; SPONTANEOUS ABORTION; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOCYTOPENIA; VASCULAR DISEASE;

ABORTION, HABITUAL; ANTIBODIES, ANTIPHOSPHOLIPID; ANTIPHOSPHOLIPID SYNDROME; FEMALE; HISTORY, 20TH CENTURY; HUMANS; LUPUS COAGULATION INHIBITOR; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; NEOPLASMS; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; THROMBOPHILIA; VENOUS THROMBOSIS;

EID: 50249103825     PISSN: 00946176     EISSN: 10989064     Source Type: Journal    
DOI: 10.1055/s-0028-1082266     Document Type: Article

References (53)

1. Bowie EJ, Thompson JH Jr, Pascuzzi CA, Owens CA Jr. Thrombosis in systemic lupus erythematosus despite circulating anticoagulants. J Lab Clin Med 1963;62:416-430
2. Alarcón-Segovia D, Osmundson PJ. Peripheral vascular syndromes associated with systemic lupus erythematosus. Ann Intern Med 1965;62:907-919
3. Harris EN, Baguley E, Asherson RA, Hughes GRV. Clinical and serological features of the antiphospholipid syndrome (APS) [abstract]. Br J Rheumatol 1987;26(Suppl 2)':19
4. Tan EM, Cohen AS, Fries FJ, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-1277
5. Asherson RA, Cervera R, Lahita R. Latent, incomplete or lupus at all? J Rheumatol 1991;18:1783-1786
6. Cervera R, Piette JC, Font J, et al. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis Rheum 2002;46:1019-1027
7. Soulier MC, Boffa MC. Avortements à répétition, thromboses et anticoagulant circulant antithromboplastine. Nouv Presse Med 1980;9:859-864
8. Carreras LO, Defreyn G, Machin SJ, et al. Arterial thrombosis, intrauterine death and "lupus" anticoagulant detection of immunoglobulin interfering with prostacyclin formation. Lancet 1981;1:244-246
9. Carreras LO, Vermylen J, Spitz B, Van Assche A. Lupus anticoagulant and inhibition of prostacyclin formation in patients with repeated abortion, intrauterine growth retardation and intrauterine death. Br J Obstet Gynaecol 1981;88:890-894
10. Beaumont H. Syndrome hémorrhagique acquis du a un anticoagulant. Sang 1954;25:1-5
11. Krulik M, Tobelem G, Audebert AA, Mougent-Martin M, Debray J. Les anticoagulants circulants au cours du lupus érythématosus disséminé. A propos de trios observations. Ann Med Interne (Paris) 1977;128:57-62
12. Nilsson IM, Astedt B, Hedner U, et al. Intrauterine death and circulating anticoagulant "antithromboplastin". Acta Med Scand 1975;197:153-159
13. Grennan DM, McCormack JN, Wojtacha D, Carty M, Behan W. Immunological studies of the placenta in systemic lupus erythematosus. Ann Rheum Dis 1978;37:129-134
14. Abramowsky CR, Vegas ME, Swinehart G, Gyves MT. Decidual vasculopathy of the placenta and lupus erythematosus. N Engl J Med 1980;303:668-672
15. Derue GJ, Englert HJ, Harris EN, Gharavi AE, Morgan SH, Hull RG. Fetal loss in systemic lupus erythematosus; association with anticardiolipin antibodies. Br J Obstet Gynaecol 1985;5:207-209
16. Rand JH, Wu XX, Guller S, et al. Reduction of Annexin V (placental anticoagulant protein-1) on placental villi of women with antiphospholipid antibodies and recurrent spontaneous abortion. Am. J Obstet Gynaecol 1994;337:154-160
17. Salmon JE, Girardi G, Holers VM. Activation of complement mediates antiphospholipid antibody-induced pregnancy loss. Lupus 2003;12:535-538
18. Asherson RAA. 'Primary' antiphospholipid syndrome? J Rheumatol 1988;15:1742-1746
19. Font J, Cervera R. Sindrome antifosfolipido primario: una nueva entidad? Med Clin (Barc) 1988;91:736-738
20. Asherson RA, Khamashta MA, Ordi-Ros J, et al. The 'primary' antiphospholipid syndrome: major clinical and serological features. Medicine (Baltimore) 1989;68:366-374
21. Mackworth-Young CG, Loizou S, Walport MJ. Primary antiphospholipid syndrome. Ann Rheum Dis 1989;48:362-367
22. Alarcón-Segovia D, Sánchez-Guerrero J. Primary antiphospholipid syndrome. J Rheumatol 1989;16:482-488
23. Font J, López-Soto A, Cervera R, et al. The 'primary' antiphospholipid syndrome. Autoimmunity 1991;9:69-75
24. Asherson RA, Schamroth-Rapaport N, Skudowitz B, Singh S, Marx D, Miesbach W. Recurrent deep vein thrombosis, ovarian carcinoma and antibodies to mitochondria M5 in a patient with asymptomatic primary "plus" antiphospholipid syndrome: an unusual combination. Clin Exp Rheumatol 2007;25:890-895
25. Piette JC, Wechsler B, Francès C, Papo T, Godeau P. Exclusion criteria for primary antiphospholipid syndrome. J Rheumatol 1993;20:1802-1804
26. Hughes GR. The Prosser-White oration 1983. Connective tissue diseases and the skin. Clin Exp Dermatol 1984;9:535-544
27. Khamashta MA, Mackworth-Young C. Antiphospholipid (Hughes') syndrome. BMJ 1997;314:253-257
28. Alarcon-Segovia D. The antiphospholipid story. J Rheumatol 2003;30:1893-1896
29. Ehrenstein MR, Swana M, Keeling D, Asherson RA, Hughes GRV, Isenberg DA. Anti DNA antibodies in the primary antiphospholipid syndrome (PAPS). Br J Rheumatol 1993;32:362-365
30. Neogi T, Gladman DD, Ibanez D, Urowitz M. AntidsDNA antibody testing by Farr and ELISA techniques is not equivalent. J Rheumatol 2006;33:1785-1788
31. Asherson RA, Shoenfeld Y. The significance of antibodies to ssDNA in the primary antiphospholipid syndrome. Clin Exp Rheumatol 1994;12:1-3
32. Asherson RA, Miyawaki J, Wen R, et al. Anti-ssDNA in the primary antiphospholipid syndrome. Lupus 1992;l(Suppl 1): 46
33. Andreoli L, Pregnolato F, Burlingame R, et al. Antinucleo-some antibodíes in primary antiphospholipid syndrome. Clin Exp Rheumatol 2007;25:A25
34. Vianna JL, Khamashta MA, Ordi-Ros J, et al. Comparison of the primary and secondary antiphospholipid syndrome: a European multicenter study of 114 patients. Am J Med 1994;96:3-9
35. Seisdedos L, Muñoz-Rodriguez FJ, Cervera R, Font J, Ingelmo M. Primary antiphospholipid syndrome evolving into systemic lupus erythematosus. Lupus 1997;6:285-286
36. Font J, Cervera R, López-Soto A, et al. Anticardiolipin antibodies in patients with autoimmune diseases: isotype distribution and clinical association. Clin Rheumatol 1989;8:475-483
37. Miesbach W. Antiphospholipid antibodies and antiphospholipid syndrome in patients with malignancies: features, incidence, identification, and treatment. Semin Thromb Hemost 2008;34:282-285
38. Mueh JR, Herbst KD, Rapaport SI. Thrombosis in patients with the lupus anticoagulant. Ann Intern Med 1980;92:156-159
39. Gómez-Puerta JA, Cervera R, Espinoza G, et al. Antiphospholipid antibodies associated with malignancies: clinical and pathological characteristics of 120 patients. Semin Arthritis Rheum 2006;35:322-332
40. Zandman Goddard G, Shoenfeld Y. Antiphospholipid antibodies and infections-drugs. In: Asherson RA, Cervera R, Piette J-C, Shoenfeld Y, eds. The Antiphospholipid Syndrome 11. Amsterdam, The Netherlands: Elsevier; 2002:343-360
41. Cervera R, Asherson RA. Antiphospholipid antibodies associated with infections. Clinical and microbiological characteristics. Immunobiology 2005;210:735-741
42. Drenkard C, Sánchez-Guerrero J, Alarcón-Segovia D. Fall in antiphospholipid antibody at the time of thromboocclusive episodes in systemic lupus erythematosus. J Rheumatol 1989;16:614-617
43. Miret C, Cervera R, Reverter JC, et al. Antiphospholipid syndrome without 'seronegative' antiphospholipid antibodies at the time of the thrombotic event: transient antiphospholipid syndrome plasminogen activator inhibitor. Clin Exp Rheumatol 1997;15:541-544
44. Joseph J, Scopelitis E. Seronegative antiphospholipid syndrome associated with plasminogen activator inhibitor. Lupus 1994;3:201-203
45. McCarthy GA. Seronegative APS (SNAPS) in 53 patients: seroconversion rate at 3.5 yrs [abstract]. J Autoimmun 2000:15OC35
46. Bird AG, Lendrum R, Asherson RA, Hughes GRV. Disseminated intravascular coagulation, antiphospholipid antibodies and ischemic necrosis of the extremities. Ann Rheum Dis 1987;46:251-259
47. Ingram SB, Goodnight SH, Bennett RM. An unusual syndrome of a devastating non-inflammatory vasculopathy associated with anticardiolipin antibodies. Arthritis Rheum 1987;30:1167-1172
48. Greisman SG, Thayaparan R-S, Godwin TA, Lockshin MD. Occlusive vasculopathy in systemic lupus erythematosus - association with anticardiolipin antibody. Arch Intern Med 1991;151:389-392
49. Harris EN, Bos K. An acute disseminated coagulopathy-vasculopathy associated with the antiphospholipid syndrome. Arch Intern Med 1991;151:231-232
50. Asherson RA. The catastrophic antiphospholipid antibody syndrome. J Rheumatol 1992;19:508-512
51. Piette JC, Cervera R, Levy R, Nasonov EL, Triplett DA, Shoenfeld Y. The catastrophic antiphospholipid syndrome - Asherson's syndrome. Ann Med Interne (Paris) 2003;154:95-96
52. Makatsariya A, Asherson RA, Bitsazde V, Baimuradova S, Akinshina S. Catastrophic antiphospholipid (Asherson's) syndrome and genetic thrombophilic disorders. Autoimmun Rev 2006;6:89-93
53. Merrill JT, Asherson RA. The catastrophic antiphospholipid syndrome. Nat Clin Pract Rheumatol 2006;2:81-89