Microhemorrhages in nonfatal high-altitude cerebral edema

Journal of Cerebral Blood Flow and Metabolism

Volumn 28, Issue 9, 2008, Pages 1635-1642

  Kallenberg, Kai ^a   Dehnert, Christoph ^b   Dörfler, Arnd ^c   Schellinger, Peter D ^c   Bailey, Damian M ^d   Knauth, Michael ^a,e   Bärtsch, Peter D ^b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^d UNIVERSITY OF GLAMORGAN   (United Kingdom)

^e UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

Cerebral edema; High altitude; Intracerebral hemorrhage; MRI

Indexed keywords

HEMOSIDERIN;

ADULT; AGED; ALTITUDE DISEASE; ARTICLE; BRAIN EDEMA; BRAIN HEMORRHAGE; CLINICAL ARTICLE; CORPUS CALLOSUM; FEMALE; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL;

ALTITUDE; ALTITUDE SICKNESS; BRAIN EDEMA; CEREBRAL HEMORRHAGE; CORPUS CALLOSUM; HEMOSIDERIN; HUMANS; MAGNETIC RESONANCE IMAGING; TIME FACTORS;

EID: 50249099182     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2008.55     Document Type: Article

References (28)

1. Bailey DM, Roukens R, Knauth M, Kallenberg K, Christ S, Mohr A, Genius J, Storch-Hagenlocher B, Meisel F, McEneny J, Young IS, Steiner T, Hess K, Bärtsch P (2006) Free radical-mediated damage to barrier function is not associated with altered brain morphology in high-altitude headache. J Cereb Blood Flow Metab 26:99-111
2. Bärtsch P, Roach RC (2001) Acute mountain sickness and high-altitude cerebral edema. In: High altitude. an exploration of human adaptation (Hornbein TF, Schoene RB, eds). New York, NY: Marcel Dekker, 731-76
3. Blitstein MK, Tung GA (2007) MRI of cerebral micro-hemorrhages. AJR Am J Roentgenol 189:720-5
4. Dickinson J, Heath D, Gosney J, Williams D (1983) Altitude-related deaths in seven trekkers in the Himalayas. Thorax 38:646-56
5. Fayed N, Modrego PJ, Morales H (2006) Evidence of brain damage after high-altitude climbing by means of magnetic resonance imaging. Am J Med 119:168;e1-e6
6. Garrido E, Castello A, Ventura JL, Capdevila A, Rodriguez FA (1993) Cortical atrophy and other brain magnetic resonance imaging (MRI) changes after extremely high-altitude climbs without oxygen. Int J Sports Med 14:232-4
7. Garrido E, Segura R, Capdevila A, Aldoma J, Rodriguez FA, Javierra C, Ventura JL (1995) New evidence from magnetic resonance imaging of brain changes after climbs at extreme altitude. Eur J Appl Physiol Occup Physiol 70:477-81
8. Greenberg SM, Vonsattel JP, Stakes JW, Gruber M, Finklestein SP (1993) The clinical spectrum of cerebral amyloid angiopathy: presentations without lobar hemorrhage. Neurology 43:2073-9
9. Haacke EM, Xu Y, Cheng YC, Reichenbach JR (2004) Susceptibility weighted imaging (SWI). Magn Reson Med 52:612-8
10. Hackett PH, Rennie D, Levine HD (1976) The incidence, importance, and prophylaxis of acute mountain sickness. Lancet 2:1149-55
11. Hackett PH, Yarnell PR, Hill R, Reynard K, Heit J, McCormick J (1998) High-altitude cerebral edema evaluated with magnetic resonance imaging: clinical correlation and pathophysiology. JAMA 280:1920-5
12. Hackett PH (1999) The cerebral etiology of high-altitude cerebral edema and acute mountain sickness. Wilderness Environ Med 10:97-109
13. Houston CS, Dickinson J (1975) Cerebral form of high-altitude illness. Lancet 2:758-61
14. Jeong JH, Kwon JC, Chin J, Yoon SJ, Na DL (2002) Globus pallidus lesions associated with high mountain climbing. J Korean Med Sci 17:861-3
15. Kallenberg K, Bailey DM, Christ S, Mohr A, Roukens R, Menold E, Steiner T, Bartsch P, Knauth M (2007) Magnetic resonance imaging evidence of cytotoxic cerebral edema in acute mountain sickness. J Cereb Blood Flow Metab 27:1064-71
16. Lonjon M, Roche JL, George B, Mourier KL, Paquis P, Lot G, Grellier P (1993) Intracranial cavernoma. 30 cases. Presse Med 22:990-4
17. Miserocchi G, Passi A, Negrini D, Del Fabbro M, De Luca G (2001) Pulmonary interstitial pressure and tissue matrix structure in acute hypoxia. Am J Physiol Lung Cell Mol Physiol 280:L881-7
18. Roach RC, Bärtsch P, Hackett PH, Oelz O (1993) The Lake Louise acute mountain sickness scoring system, vol. 272-274 Burlington: Queen City Printers
19. Sampson JB, Cymerman A, Burse RL, Maher JT, Rock PB (1983) Procedures for the measurement of acute mountain sickness. Aviat Space Environ Med 54:1063-73
20. Schoonman GG, Sandor PS, Nirkko AC, Lange T, Jaermann T, Dydak U, Kremer C, Ferrari MD, Boesiger P, Baumgartner RW (2007) Hypoxia-induced acute mountain sickness is associated with intracellular cerebral edema: a 3 T magnetic resonance imaging study. J Cereb Blood Flow Metab 28:198-206
21. Singh I, Khanna PK, Srivastava MC, Lal M, Roy SB, Subramanyam CS (1969) Acute mountain sickness. N Engl J Med 280:175-84
22. Swenson ER, Maggiorini M, Mongovin S, Gibbs JS, Greve I, Mairbaurl H, Bartsch P (2002) Pathogenesis of high-altitude pulmonary edema: inflammation is not an etiologic factor. JAMA 287:2228-35
23. Tissot van Patot MC, Leadbetter G, Keyes LE, Bendrick-Peart J, Beckey VE, Christians U, Hackett P (2005) Greater free plasma VEGF and lower soluble VEGF receptor-1 in acute mountain sickness. J Appl Physiol 98:1626-9
24. Tsushima Y, Aoki J, Endo K (2003) Brain microhemorrhages detected on T2*-weighted gradient-echo MR images. AJNR Am J Neuroradiol 24:88-96
25. Usui C, Inoue Y, Kimura M, Kirino E, Nagaoka S, Abe M, Nagata T, Arai H (2004) Irreversible subcortical dementia following high altitude illness. High Alt Med Biol 5:77-81
26. Vernooij MW, Ikram MA, Tanghe HL, Vincent AJ, Hofman A, Krestin GP, Niessen WJ, Breteler MM, van der Lugt A (2007) Incidental findings on brain MRI in the general population. N Engl J Med 357:1821-1828
27. Wong SH, Turner N, Birchall D, Walls TJ, English P, Schmid ML (2004) Reversible abnormalities of DWI in high-altitude cerebral edema. Neurology 62:335-6
28. Xu F, Severinghaus JW (1998) Rat brain VEGF expression in alveolar hypoxia: possible role in high-altitude cerebral edema. J Appl Physiol 85:53-7