Role of the conserved distal heme asparagine of coral allene oxide synthase (Asn137) and human catalase (Asn148): Mutations affect the rate but not the essential chemistry of the enzymatic transformations

Archives of Biochemistry and Biophysics

Volumn 477, Issue 2, 2008, Pages 285-290

  Gao, Benlian ^a   Boeglin, William E ^a   Brash, Alan R ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Allene oxide; Allene oxide synthase; Catalase; Distal heme; Enzyme kinetics; HPETE; Hydrogen peroxide; Hydroperoxyeicosatetraenoic acid; Peroxidase

Indexed keywords

8 HYDROXYPEROXYEICOSATETRAENOIC ACID; ALLENE DERIVATIVE; ALLENE OXIDE SYNTHASE; ASPARAGINE; CATALASE; FATTY ACID; HYDROGEN PEROXIDE; LIPOXYGENASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMISTRY; CORAL; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SUBSTRATE; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SITE DIRECTED MUTAGENESIS; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; ANTHOZOA; ASPARAGINE; CATALASE; CONSERVED SEQUENCE; ENZYME ACTIVATION; ENZYME STABILITY; HEME; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; KINETICS; MOLECULAR SEQUENCE DATA; MUTATION; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

ANTHOZOA;

EID: 50149117920     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2008.07.011     Document Type: Article

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