Antitumor activity of extracts and compounds from the rhizomes of Veratrum dahuricum

Phytotherapy Research

Volumn 22, Issue 8, 2008, Pages 1093-1096

  Tang, Jian ^a   Li, Hui Liang ^b   Shen, Yun Heng ^b   Jin, Hui Zi ^a   Yan, Shi Kai ^a   Liu, Run Hui ^b   Zhang, Wei Dong ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Antitumor activity; Cyclopamine; Germine; Veratrum dahuricum

Indexed keywords

CHLOROFORM; CYCLOPAMINE; GERMINE DERIVATIVE; JERVINE; PLANT EXTRACT; UNCLASSIFIED DRUG; VERAMITALINE; VERATRAMINE; VERATROSINE; VERATRUM ALKALOID; VERATRUM DAHURICUM EXTRACT;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG INHIBITION; DRUG STRUCTURE; HUMAN; HUMAN CELL; MEDICINAL PLANT; RHIZOME; VERATRUM DAHURICUM;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL FRACTIONATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; NEOPLASMS; PLANT EXTRACTS; RHIZOME; VERATRUM; VERATRUM ALKALOIDS;

VERATRUM;

EID: 50149114699     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2463     Document Type: Article

References (11)

1. Berman DM, Karhadkar SS, Hallahan AR et al. 2002. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 297: 1559-1561.
2. Carmichael J, DeGraff WG, Dazdar AF et al. 1987. Evaluation of a tetrazolium-based semiautomated colorimetric assay-assessment of chemosensitivity testing. Cancer Res 47: 936-942.
3. Editorial Board of Flora of China of Chinese Academy of Sciences. 1980. Flora of China: Vol. 14. Science Press: Beijing, 21-30.
4. Editorial Board of Zhong Hua Ben Cao of State Administration of Traditional Chinese Medicine. 1999. ZhongHua BenCao: Vol. 22. Shanghai Science and Technology Press: Shanghai, 183-188.
5. Feldmann G, Dhara S, Fendrich V et al. 2007. Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: A new paradigm for combination therapy in solid cancers. Cancer Res 67: 2187-2196.
6. Li HL, Tang J, Liu RH et al. 2007. Characterization and identifi-cation of steroidal alkaloids in the Chinese herb Veratrum nigrum L. by high-performance liquid chromatography/ electrospray ionization with multistage mass spectrometry. Rapid Commun Mass Spectrom 21: 869-879.
7. Lu DR, Dai FB. 2005. The use of veratramine as inhibitor to signal transduction. CN 1689559A. Intellectual Property Publishing House: Beijing.
8. Tang J, Li HL, Shen YH et al. 2007. Four new germine esters from Veratrum dahuricum. Helv Chim Acta 90: 769-775.
9. Thayer SP, Di Magliano MP, Heiser PW et al. 2003. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425: 851-856.
10. Watkins DN, Berman DM, Burkholder SG et al. 2003. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 422: 313-317.
11. Xu GJ, Xu LS, Wang ZT. 2001. Species Systematization and Quality Evaluation of Commonly Used Chinese Traditional Drugs: Section 4. Fujian Science and Technology Press: Fujian, 121-178.