The iron-sulfur cluster of electron transfer flavoprotein-ubiquinone oxidoreductase is the electron acceptor for electron transfer flavoprotein

Biochemistry

Volumn 47, Issue 34, 2008, Pages 8894-8901

  Swanson, Michael A ^a   Usselman, Robert J ^a   Frerman, Frank E ^b   Eaton, Gareth R ^a   Eaton, Sandra S ^a  

^a UNIVERSITY OF DENVER   (United States)

^b Children's Hospital Colorado   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORINE COMPOUNDS; ELECTRON TRANSITIONS; ENZYMES; SULFUR;

ELECTRON ACCEPTORS; ELECTRON TRANSFER; IRON-SULFUR CLUSTERS; OXIDOREDUCTASE; UBIQUINONE;

ELECTRONS;

ASPARAGINE DERIVATIVE; ELECTRON TRANSFERRING FLAVOPROTEIN; FLAVINE ADENINE NUCLEOTIDE; IRON SULFUR PROTEIN; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); UBIQUINONE DERIVATIVE;

ARTICLE; ELECTRON SPIN RESONANCE; ELECTRON TRANSPORT; HYDROGEN BOND; MUTAGENESIS; MUTATION; NONHUMAN; OXIDATION REDUCTION POTENTIAL; PRIORITY JOURNAL; PROTEIN FUNCTION; RHODOBACTER SPHAEROIDES;

ANIMALS; ASPARAGINE; CRYSTALLOGRAPHY, X-RAY; ELECTRON SPIN RESONANCE SPECTROSCOPY; ELECTRON TRANSPORT; ELECTRON-TRANSFERRING FLAVOPROTEINS; FLAVIN-ADENINE DINUCLEOTIDE; HYDROGEN BONDING; IRON; IRON-SULFUR PROTEINS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; PROTEIN STRUCTURE, SECONDARY; SULFUR; SWINE; TEMPERATURE; THREONINE;

RHODOBACTER SPHAEROIDES; SUS;

EID: 50149109392     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800507p     Document Type: Article

References (26)

1. Ruzicka, F. J., and Beinert, H. (1977) A new iron-sulfur protein of the respiratory chain: a component of the fatty acid oxidation pathway. J. Biol. Chem. 252, 8440-8445.
2. Toogood, H. S., Leys, D., and Scrutton, N. S. (2007) Dynamics driving function - new insights from electron transferring flavoproteins and partner complexes. FEBS J. 274, 5481-5504.
3. Goodman, S. I., Binard, R. J., Woontner, M. R., and Frerman, F. E. (2002) Glutaric acidemia type II: gene structure and mutations of the electron transfer flavoprotein ubiquinone oxidoreductase (ETF-QO) gene. Mol. Genet. Metab. 77, 86-90.
4. Beresford, M. W., Pourfarzam, M., Turnbull, D. M., and Davidson, J. E. (2006) So doctor, what exactly is wrong with my muscles? Glutaric aciduria type II presenting in a teenager. Neuromuscular Disord. 16, 269-273.
5. Zhang, J., Frerman, F. E., and Kim, J.-J. (2006) Structure of electron transfer flavoprotein ubiquinone oxidoreductase and electron transfer to the mitochondrial ubuiquinone pool. Proc. Natl. Acad. Sci. U.S.A. 103, 16212-16217.
6. Page, C. C., Moser, C. C., Chen, X., and Dutton, P. L. (1999) Natural engineering principals of electron tunnelling in biological oxidation-reduction. Nature 402, 47-52.
7. Chothia, C., and Lesk, A. M. (1986) The relation between the divergence of sequence and structure in proteins. EMBO J. 5, 823-826.
8. + Cluster and on the Catalytic Activity in Electron Transfer Flavoprotein-ubiquinone Oxidoreductase (ETF-QO). Biochemistry 47, 92-100.
9. Breinlinger, E., Niemz, A., and Rotello, V. M. (1995) Model systems for flavoenzyme activity. Stabilization of the flavin radical anion through specific hydrogen bond interactions. J. Am. Chem. Soc. 117, 5379-5380.
10. Miroux, B., and Walker, J. E. (1996) Overproduction of proteins in Escherichia coli: mutant hosts that allow synthesis of some membrane proteins and globular proteins at high levels. J. Mol. Biol. 260, 289-298.
11. Wu, G., Mansey, S. S., Wu, S., Suresus, K. K., Foster, M. W., and Cowan, J. A. (2002) Characterization of an iron-sulfur cluster assembly protein (ISU1) from Schizosaccharomyces pombe. Biochemistry 41, 5024-5032.
12. Siegel, L. M. (1978) Quantitative determination of noncovalently bound flavins: types and methods of analysis. Methods Enzymol. 53, 419-429.
13. Ramsay, R. R., Steenkamp, D. J., and Husain, M. (1987) Reactions of electron transfer flavoprotein and electron transfer flavoprotein-ubiquinone oxidoreductase. Biochem. J. 241, 883-892.
14. Beckmann, J. D., and Frerman, F. E. (1985) Electron transfer flavoprotein-ubiquinone oxidoreductase from pig liver: purification and molecular, redox and catalytic properties. Biochemistry 24, 3913-3921.
15. Fersht, A. (1988) in Structure and Mechanism in Protein Science, pp 104-105, W. H. Freeman and Co., New York.
16. Patil, P. V., and Ballou, D. P. (2000) The use of protocatechuate dioxygenase for maintaining anaerobic conditions in biochemical experiments. Anal. Biochem. 286, 187-192.
17. Dutton, P. L. (1978) Redox potentiomery: determination of mid-point potentials of oxidation reduction components of biological electron transfer systems. Methods Enzymol. 54, 411-435.
18. Fielding, A. J., Usselman, R. J., Watmough, N., Simkovic, M., Frerman, F. E., Eaton, G. R., and Eaton, G. R. (2008) Electron Paramagnetic Resonance Characterization and Interspin Distance Measurement of Electron Transfer Flavoprotein Ubiquinone Oxidoreductase (ETF-QO). J. Magn. Reson. 190, 222-232.
19. m effects. Biol. Magn. Reson. 19, 347-381.
20. Rakowsky, M. H., More, K. M., Kulikov, A. V., Eaton, G. R., and Eaton, S. S. (1995) Time-Domain Electron Paramagnetic Resonance as a Probe of Electron-Electron Spin-Spin Interaction in Spin-Labeled Low-Spin Iron Porphyrins. J. Am. Chem. Soc. 117, 2049-2057.
21. Paulsen, K. E., Orville, A. M., Frerman, F. E., Lipscomb, J. D., and Stankovich, M. T. (1992) Redox properties of electron-transfer flavoprotein ubiquinone oxidoreductase as determined by EPR-spectroelectrochemistry. Biochemistry 31, 11755-11761.
22. Eaton, S. S., and Eaton, G. R. (2000) Relaxation times of organic radicals and transition metal ions. Biol. Magn. Reson. 19, 29-154.
23. 2. Role of the driving force in intramolecular electron transfer kinetics. Biochemistry 37, 12761-12771.
24. Coves, J., Zeghouf, M., Macherel, D., Guigliarelli, B., Asso, M., and Fontecave, M. (1997) Flavin mononucleotide-binding domain of the flavoprotein component of the sulfite reductase from Escherichia coli. Biochemistry 36, 5921-5928.
25. Simkovic, M., Degala, G. D., Eaton, S. S., and Frerman, F. E. (2002) Expression of human electron transfer flavoprotein-ubiquinone oxidoreductase from a baculovirus vector: kinetic and spectral characterization of the human protein. Biochem. J. 364, 659-667.
26. Zhang, J., Frerman, F. E., and Kim, J.-J. (2006) Structure of electron transfer flavoprotein ubiquinone oxidoreductase and electron transfer to the mitochondrial ubuiquinone pool. Proc. Natl. Acad. Sci. U.S.A. 103, 16212-16217.