Determination of azelnidipine by LC-ESI-MS and its application to a pharmacokinetic study in healthy Chinese volunteers

Pharmazie

Volumn 63, Issue 8, 2008, Pages 568-570

  Jian Jun, Zou ^a   Hong Jian, Ji ^b   Xiao Hua, Zhou ^b   Yu Bin, Zhu ^a   Hong Wei, Fan ^a   Da Wei, Xiao ^a   Qin, Hu ^b  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIUM ACETATE; AZELNIDIPINE; ETHER; METHANOL; PEROSPIRONE; SODIUM HYDROXIDE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CHINESE; CLINICAL TRIAL; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIQUID LIQUID EXTRACTION; MALE; MAXIMUM PLASMA CONCENTRATION; MULTIPLE DRUG DOSE; NORMAL HUMAN; PH; PHARMACOKINETICS; PLASMA; QUANTITATIVE ANALYSIS; SINGLE DRUG DOSE; STANDARD; STEADY STATE; TIME TO MAXIMUM PLASMA CONCENTRATION; VOLUNTEER;

EID: 50149104995     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2008.8062     Document Type: Article

References (6)

1. Ding L, Li L, Ma PC (2007) Determination of azelnidipine in human plasma by liquid chromatography-electrospray ionization-mass spectrometry. J Pharm Biomed Anal 43: 575-579.
2. 2+-channel blockers on the induction of inducible nitric oxide synthase in vascular smooth muscle cells. J Cardiovasc Pharmacol 47: 314-321.
3. Kiyoshi K, Yoko U (2006) Simultaneous determination of azelnidipine and two metabolites in human plasma using liquid chromatography-tandem mass spectrometry. J Chromatogr B 844: 45-52.
4. Kiyoshi K, Naozumi S, Yoko U, Ichiro F, Naoki U, Eiji U, Hajime Y (2007) Enantioselective determination of azelnidipine in human plasma using liquid chromatography-tandem mass spectrometr. J Chromatogr B 852: 389-397.
5. Koike H, Kimura T, Kawasaki T, Sada T, Ikeda T, Sanbuissho A, Saito H (2002) Azelnidipine, a long-acting calcium channel blocker with slow onset and high vascular affinity. Annu Rep Sankyo Res Lab 54: 1-64.
6. Kuramoto K, Ichikawa S, Hirai A, Kanada S, Nakachi T, Ogihara T (2003) Azelnidipine and amlodipine: a comparison of their pharmacokinetics and effects on ambulatory blood pressure. Hypertens Res 26:201-208.