Dual regulation of NR2B and NR2C expression by NMDA receptor activation in mouse cerebellar granule cell cultures

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 33, 2008, Pages 12010-12015

  Iijima, Kouichirou ^a,b   Abe, Haruka ^a,b   Okazawa, Makoto ^a   Moriyoshi, Koki ^b   Nakanishi, Shigetada ^a  

^a OSAKA BIOSCIENCE INSTITUTE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Cerebellar development; Gene regulation; Glutamate receptor; Synaptic maturation

Indexed keywords

AMPA RECEPTOR; AMPA RECEPTOR AGONIST; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2C; POTASSIUM CHLORIDE; PROTEIN SUBUNIT;

ANIMAL CELL; ARTICLE; BIOTINYLATION; BRAIN DEVELOPMENT; CELL CULTURE; CELL MATURATION; CELL STRUCTURE; CONTROLLED STUDY; DOWN REGULATION; GRAY MATTER; NERVE CELL EXCITABILITY; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYNAPTIC MEMBRANE; UPREGULATION;

ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; CELL MEMBRANE; CELLS, CULTURED; CEREBELLUM; GLUTAMATES; MICE; MICE, INBRED ICR; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN SUBUNITS; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 50149098951     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0805574105     Document Type: Article

References (33)

1. Sanes JR, Lichtman JW (2001) Induction, assembly, maturation and maintenance of a postsynaptic apparatus. Nat Rev Neurosci 2:791-805.
2. 2+ signalling in development and maturation of mammalian cerebellar granule cells. J Physiol 575:389-395.
3. Nakanishi S (1992) Molecular diversity of glutamate receptors and implications for brain function. Science 258:597-603.
4. Akazawa C, Shigemoto R, Bessho Y, Nakanishi S, Mizuno N (1994) Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats. J Comp Neurol 347:150-160.
5. Watanabe M, Mishina M, Inoue Y (1994) Distinct spatiotemporal expressions of five NMDA receptor channel subunit mRNAs in the cerebellum. J Comp Neurol 343:513-519.
6. Farrant M, Feldmeyer D, Takahashi T, Cull-Candy SG (1994) NMDA-receptor channel diversity in the developing cerebellum. Nature 368:335-339.
7. Kadotani H, et al. (1996) Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit. J Neurosci 16:7859-7867.
8. Gallo V, Kingsbury A, Balázs R, Jørgensen OS (1987) The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J Neurosci 7:2203-2213.
9. +-induced depolarization and NMDA treatment. Neuron 12:87-95.
10. Audinat E, Lambolez B, Rossier J, Crépel F (1994) Activity-dependent regulation of N-methyl-D-aspartate receptor subunit expression in rat cerebellar granule cells. Eur J Neurosci 6:1792-1800.
11. Vallano ML, Lambolez B, Audinat E, Rossier J (1996) Neuronal activity differentially regulates NMDA receptor subunit expression in cerebellar granule cells. J Neurosci 16:631-639.
12. Chadderton P, Margrie TW, Häusser M (2004) Integration of quanta in cerebellar granule cells during sensory processing. Nature 428:856-860.
13. Condorelli DF, et al. (1993) Growth conditions differentially regulate the expression of α-amino-3-hydroxy-5-methylisoxazole-4- propionate (AMPA) receptor subunits in cultured neurons. J Neurochem 61:2133-2139.
14. A receptor α6 subunit gene. J Neurosci 18:2822-2833.
15. Sato M, Suzuki K, Yamazaki H, Nakanishi S (2005) A pivotal role of calcineurin signaling in development and maturation of postnatal cerebellar granule cells. Proc Natl Acad Sci USA 102:5874-5879.
16. Suzuki K, Sato M, Morishima Y, Nakanishi S (2005) Neuronal depolarization controls brain-derived neurotrophic factor-induced upregulation of NR2C NMDA receptor via calcineurin signaling. J Neurosci 25:9535-9543.
17. Mogensen HS, Hack N, Balázs R, Jørgensen OS (1994) The survival of cultured mouse cerebellar granule cells is not dependent on elevated potassium-ion concentration. Int J Dev Neurosci 12:451-460.
18. Mason CA, Gregory E (1984) Postnatal maturation of cerebellar mossy and climbing fibers: transient expression of dual features on single axons. J Neurosci 4:1715-1735.
19. Sheardown MJ, Nielsen EØ, Hansen AJ, Jacobsen P, Honoré T (1990) 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia. Science 247:571-574.
20. 3H]D-AP5 binding sites on brain membranes and anticonvulsant activity. Brain Res 382:169-173.
21. Nowak L, Bregestovski P, Ascher P, Herbet A, Prochiantz A (1984) Magnesium gates glutamate-activated channels in mouse central neurones. Nature 307:462-465.
22. von Engelhardt J, et al. (2007) Excitotoxicity in vitro by NR2A- and NR2B-containing NMDA receptors. Neuropharmacology 53:10-17.
23. Zhou M, Baudry M (2006) Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors. J Neurosci 26:2956-2963.
24. Kennedy MB, Beale HC, Carlisle HJ, Washburn LR (2005) Integration of biochemical signalling in spines. Nat Rev Neurosci 6:423-434.
25. 2+-calmodulin and protein kinase Cs: a hypothetical synthesis of their conflicting convergences on shared substrate domains. Trends Neurosci 22:12-16.
26. Xia Z, Storm DR (2005) The role of calmodulin as a signal integrator for synaptic plasticity. Nat Rev Neurosci 6:267-276.
27. 2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells. Biochem Biophys Res Commun 181:968-975.
28. Pláteník J, Kuramoto N, Yoneda Y (2000) Molecular mechanisms associated with long-term consolidation of the NMDA signals. Life Sci 67:335-364.
29. Cuenda A, et al. (1995) SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 364:229-233.
30. Favata MF, et al. (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273:18623-18632.
31. Rossi P, De Filippi G, Armano S, Taglietti V, D'Angelo E (1998) The weaver mutation causes a loss of inward rectifier current regulation in premigratory granule cells of the mouse cerebellum. J Neurosci 18:3537-3547.
32. Schlett K, et al. (2004) Long-term NR2B expression in the cerebellum alters granule cell development and leads to NR2A down-regulation and motor deficits. Mol Cell Neurosci 27:215-226.
33. Sato M, Suzuki K, Nakanishi S (2001) NMDA receptor stimulation and brain-derived neurotrophic factor upregulate homer 1a mRNA via the mitogen-activated protein kinase cascade in cultured cerebellar granule cells. J Neurosci 21:3797-3805.