Effects of injectable propofol emulsion on singlet oxygen released from activated human neutrophils and that chemically generated

Journal of Pharmacological Sciences

Volumn 107, Issue 4, 2008, Pages 460-464

  Senda, Chika ^a   Nishinaka, Yoko ^a   Arai, Toshiyuki ^b   Segawa, Hajime ^b   Mori, Hiroko ^c   Nonogawa, Mitsuru ^a   Endo, Nobuyuki ^d   Miyoshi, Takashi ^b   Yamashita, Kouhei ^b   Sasada, Masataka ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY HOSPITAL   (Japan)

^c Higashiyama Takeda Hospital   (Japan)

^d WAKASA WAN ENERGY RESEARCH CENTER   (Japan)

Author keywords

Emulsifier; Propofol emulsion; Singlet oxygen

Indexed keywords

EMULSIFYING AGENT; INTRALIPID; PROPOFOL; SCAVENGER; SINGLET OXYGEN; ZYMOSAN;

ARTICLE; BRAIN ISCHEMIA; CELL CULTURE; CHEMOLUMINESCENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; EMULSION; HUMAN; HUMAN CELL; NEUROPROTECTION; NEUTROPHIL; OXIDATIVE STRESS; REPERFUSION INJURY; STATISTICAL ANALYSIS; ULTRAVIOLET A RADIATION; ULTRAVIOLET SPECTROPHOTOMETRY;

EID: 50149095030     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.08040SC     Document Type: Article

References (15)

1. Adembri C, Venturi L, Pellegrini-Giampietro DE. Neuroprotective effects of propofol in acute cerebral injury. CNS Drug Rev. 2007;13:333-351.
2. Sagara Y, Hendler S, Khoh-Reiter S, Gillenwater G, Carlo D, Schubert D, et al. Propofol hemisuccinate protects neuronal cells from oxidative injury. J Neurochem. 1999;73:2524-2530.
3. Ishikawa Y, Satoh T, Enokido Y, Nishio C, Ikeuchi T, Hatanaka H. Generation of reactive oxygen species, release of L-glutamate and activation of caspases are required for oxygen-induced apoptosis of embryonic hippocampal neurons in culture. Brain Res. 1999;824:71-80.
4. Valencia A, Moran J. Reactive oxygen species induce different cell death mechanisms in cultured neurons. Free Radic Biol Med. 2004;36:1112-1125.
5. Mikawa K, Akamatsu H, Nishina K, Shiga M, Maekawa N, Obara H, et al. Propofol inhibits human neutrophil functions. Anesth Analg. 1998;87:695-700.
6. Heyne B, Brault D, Fontaine-Aupart MP, Kohnen S, Tfibel F, Mouithys-Mickalad A, et al. Reactivity towards singlet oxygen of propofol inside liposomes and neuronal cells. Biochim Biophys Acta. 2005;1724:100-107.
7. Thomas AH, Lorente C, Capparelli AL, Martinez CG, Braun AM, Oliveros E. Singlet oxygen (1deltag) production by pterin derivatives in aqueous solutions. Photochem Photobiol Sci. 2003;2:245-250.
8. Lee JW, Miyawaki H, Bobst EV, Hester JD, Ashraf M, Bobst AM. Improved functional recovery of ischemic rat hearts due to singlet oxygen scavengers histidine and carnosine. J Mol Cell Cardiol. 1999;31:113-121.
9. Posner GH, Lever JR, Miura K, Lisek C, Seliger HH, Thompson A. A chemiluminescent probe specific for singlet oxygen. Biochem Biophys Res Commun. 1984;123:869-873.
10. -. Anal Biochem. 1986;159:363-369.
11. Fischer GW, Hunter KW, Wilson SR, Mease AD. Diminished bacterial defences with intralipid. Lancet. 1980;2:819-820.
12. Palmblad J, Brostrom O, Lahnborg G, Uden AM, Venizelos N. Neutrophil functions during total parenteral nutrition and Intralipid infusion. Am J Clin Nutr. 1982;35:1430-1436.
13. Klebanoff SJ. Myeloperoxidase: friend and foe. J Leukoc Biol. 2005;77:598-625.
14. Matsuo Y, Onodera H, Shiga Y, Nakamura M, Ninomiya M, Kihara T, et al. Correlation between myeloperoxidase-quantified neutrophil accumulation and ischemic brain injury in the rat. Effects of neutrophil depletion. Stroke. 1994;25:1469-1475.
15. Palmer C, Roberts RL, Young PI. Timing of neutrophil depletion influences long-term neuroprotection in neonatal rat hypoxic-ischemic brain injury. Pediatr Res. 2004;55:549-556.