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Volumn 24, Issue 8, 2008, Pages 2189-2202

Evolving concepts of type 2 diabetes management with oral medications: New approaches to an old disease

Author keywords

Glucose; Oral antidiabetic agents; Type 2 diabetes mellitus

Indexed keywords

6 (3 AMINO 1 PIPERIDINYL) 1 (2 CYANOBENZYL) 3 METHYLURACIL; ACARBOSE; ANTIDIABETIC AGENT; BILE ACID SEQUESTRANT; CANNABINOID RECEPTOR ANTAGONIST; COLESEVELAM; COLESTILAN; DIGOXIN; DIPEPTIDYL PEPTIDASE IV INHIBITOR; FENOFIBRATE; GASTRIC INHIBITORY POLYPEPTIDE ANTAGONIST; GLITAZONE DERIVATIVE; INSULIN; METFORMIN; METOPROLOL; MEVINOLIN; ORAL ANTIDIABETIC AGENT; PIOGLITAZONE; PLACEBO; PRAVASTATIN; RIMONABANT; ROSIGLITAZONE; SAXAGLIPTIN; SITAGLIPTIN; SULFONYLUREA DERIVATIVE; TARANABANT; UNINDEXED DRUG; VALPROIC ACID; VERAPAMIL; VILDAGLIPTIN; WARFARIN;

EID: 50149089590     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/03007990802212981     Document Type: Review
Times cited : (12)

References (82)
  • 1
    • 33845996154 scopus 로고    scopus 로고
    • Standards of medical care in diabetes - 2007
    • Anon
    • Anon. Standards of medical care in diabetes - 2007. Diabetes Care 2007;30(Suppl 1):S4-S41
    • (2007) Diabetes Care , vol.30 , Issue.SUPPL. 1
  • 2
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • Anon
    • Anon. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998;352:837-53
    • (1998) Lancet , vol.352 , pp. 837-853
  • 3
    • 0029147687 scopus 로고
    • Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: A randomized prospective 6-year study
    • Ohkubo Y, Kishikawa H, Araki E, et al. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Pract 1995;28:103-17
    • (1995) Diabetes Res Clin Pract , vol.28 , pp. 103-117
    • Ohkubo, Y.1    Kishikawa, H.2    Araki, E.3
  • 4
    • 34250785602 scopus 로고    scopus 로고
    • Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial: Design and methods
    • Buse JB. Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial: design and methods. Am J Cardiol 2007; 99:S21-S33
    • (2007) Am J Cardiol , vol.99
    • Buse, J.B.1
  • 6
    • 0142199812 scopus 로고    scopus 로고
    • Design of the cooperative study on glycemic control and complications in diabetes mellitus type 2: Veterans Affairs Diabetes Trial
    • Abraira C, Duckworth W, McCarren M, et al. Design of the cooperative study on glycemic control and complications in diabetes mellitus type 2: Veterans Affairs Diabetes Trial. J Diabetes Complications 2003; 17:314-22
    • (2003) J Diabetes Complications , vol.17 , pp. 314-322
    • Abraira, C.1    Duckworth, W.2    McCarren, M.3
  • 7
    • 0347133334 scopus 로고    scopus 로고
    • Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes
    • Saydah SH, Fradkin J, Cowie CC. Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes. J Am Med Assoc 2004-291:335-42
    • J Am Med Assoc , vol.2004 -291 , pp. 335-342
    • Saydah, S.H.1    Fradkin, J.2    Cowie, C.C.3
  • 8
    • 0032983666 scopus 로고    scopus 로고
    • Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: Progressive requirement for multiple therapies (UKPDS 49)
    • Turner RC, Cull CA, Frighi V, et al. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). J Am Med Assoc 1999-281:2005-12
    • J Am Med Assoc , vol.1999 -281 , pp. 2005-2012
    • Turner, R.C.1    Cull, C.A.2    Frighi, V.3
  • 9
    • 33646539120 scopus 로고    scopus 로고
    • Diets do not fail: The success of medical nutrition therapy in patients with diabetes
    • Kulkarni K. Diets do not fail: the success of medical nutrition therapy in patients with diabetes. Endocr Pract 2006;12 (Suppl 1):121-3
    • (2006) Endocr Pract , vol.12 , Issue.SUPPL. 1 , pp. 121-123
    • Kulkarni, K.1
  • 10
    • 50149091929 scopus 로고    scopus 로고
    • Available at:, last accessed July 26, 2007
    • PRECOSE (acarbose tablets) prescribing information. Available at: http://www.univgraph.com/Bayer/inserts/Precose.pdf [last accessed July 26, 2007]
    • PRECOSE (acarbose tablets) prescribing information
  • 11
    • 50149105419 scopus 로고    scopus 로고
    • Available at:, last accessed July 26, 2007
    • GLYSET(miglitol tablets) prescribing information. Available at: http://www.pfizer.com/files/products/uspi_glyset.pdf [last accessed July 26, 2007]
    • GLYSET(miglitol tablets) prescribing information
  • 13
    • 84861695998 scopus 로고    scopus 로고
    • Available at:, last accessed July 26, 2007
    • JANUVIA (sitagliptin tablets) prescribing information. Available at: http://www.merck.com/product/usa/pi_circulars/j/januvia/januvia_pi.pdf [last accessed July 26, 2007]
    • JANUVIA (sitagliptin tablets) prescribing information
  • 14
    • 50149114293 scopus 로고    scopus 로고
    • Available at:, last accessed July 26, 2007
    • STARLIX (nateglinide tablets) prescribing information. Available at: http://www.pharma.us.novartis.com/product/pi/pdf/Starlix.pdf [last accessed July 26, 2007]
    • STARLIX (nateglinide tablets) prescribing information
  • 16
    • 50149105884 scopus 로고    scopus 로고
    • MICRONASE (glyburide) prescribing information. Available at:, last accessed November 1, 2006
    • MICRONASE (glyburide) prescribing information. Available at: http://www.pfizer.com/files/products/uspi_micronase.pdf [last accessed November 1, 2006]
  • 19
    • 50149114687 scopus 로고    scopus 로고
    • AVANDIA (rosiglitazone maleate tablets) prescribing information. Available at:, last accessed July 26, 2007
    • AVANDIA (rosiglitazone maleate tablets) prescribing information. Available at: http://us.gsk.com/products/assets/us_avandia.pdf [last accessed July 26, 2007]
  • 20
    • 50149100132 scopus 로고    scopus 로고
    • ACTOS (pioglitazone hydrochloride tablets) prescribing information. Available at:, last accessed July 26, 2007
    • ACTOS (pioglitazone hydrochloride tablets) prescribing information. Available at: http://www.actos.com/actos/prescribinginfo.aspx [last accessed July 26, 2007]
  • 21
    • 7044253431 scopus 로고    scopus 로고
    • A meta-analysis comparing the effect of thiazolidinediones on cardiovascular risk factors
    • Chiquette E, Ramirez G, Defronzo R. A meta-analysis comparing the effect of thiazolidinediones on cardiovascular risk factors. Arch Intern Med 2004;164:2097-104
    • (2004) Arch Intern Med , vol.164 , pp. 2097-2104
    • Chiquette, E.1    Ramirez, G.2    Defronzo, R.3
  • 22
    • 29944436303 scopus 로고    scopus 로고
    • IDF Clinical Guidelines Task Force, Brussels: International Diabetes Federation;
    • IDF Clinical Guidelines Task Force. Global guideline for Type 2 diabetes. Brussels: International Diabetes Federation; 2005
    • (2005) Global guideline for Type 2 diabetes
  • 24
    • 33746588255 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan DM, Buse JB, Davidson MB, et al. Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2006; 29:1963-72
    • (2006) Diabetes Care , vol.29 , pp. 1963-1972
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3
  • 25
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. New Engl J Med 2007;356:2457-71
    • (2007) New Engl J Med , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 26
    • 0014914649 scopus 로고
    • A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. II. Mortality results
    • Meinert CL, Knatterud GL, Prout TE, et al. A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. II. Mortality results. Diabetes 1970;19(Suppl):789-830
    • (1970) Diabetes , vol.19 , Issue.SUPPL. , pp. 789-830
    • Meinert, C.L.1    Knatterud, G.L.2    Prout, T.E.3
  • 27
    • 50149115564 scopus 로고    scopus 로고
    • JANUMET (sitagliptin-metformin combination tablets) prescribing information. Available at:, last accessed July 26, 2007
    • JANUMET (sitagliptin-metformin combination tablets) prescribing information. Available at: http://www.merck.com/proctuct/usa/ pi_circulars/j/janumet/janumet_pi.pdf [last accessed July 26, 2007]
  • 28
    • 42149194313 scopus 로고    scopus 로고
    • Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naive patients with type 2 diabetes
    • Rosenstock J, Sankoh S, List JF. Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naive patients with type 2 diabetes. Diabetes Obes Metab 2008; 10:376-86
    • (2008) Diabetes Obes Metab , vol.10 , pp. 376-386
    • Rosenstock, J.1    Sankoh, S.2    List, J.F.3
  • 31
    • 33845472504 scopus 로고    scopus 로고
    • Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes
    • Aschner P, Kipnes MS, Lunceford JK, et al. Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care 2006;29:2632-7
    • (2006) Diabetes Care , vol.29 , pp. 2632-2637
    • Aschner, P.1    Kipnes, M.S.2    Lunceford, J.K.3
  • 32
    • 33845489598 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus
    • Raz I, Hanefeld M, Xu L, et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia 2006; 49:2564-71
    • (2006) Diabetologia , vol.49 , pp. 2564-2571
    • Raz, I.1    Hanefeld, M.2    Xu, L.3
  • 33
    • 33845476757 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone
    • Charbonnel B, Karasik A, Liu J, et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care 2006;29:2638-43
    • (2006) Diabetes Care , vol.29 , pp. 2638-2643
    • Charbonnel, B.1    Karasik, A.2    Liu, J.3
  • 34
    • 33751557143 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: A 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study
    • Rosenstock J, Brazg R, Andryuk PJ, et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther 2006; 28:1556-68
    • (2006) Clin Ther , vol.28 , pp. 1556-1568
    • Rosenstock, J.1    Brazg, R.2    Andryuk, P.J.3
  • 35
    • 33745903093 scopus 로고    scopus 로고
    • Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes
    • Pratley RE, Jauffret-Kamel S, Galbreath E, et al. Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes. Horm Metab Res 2006;38:423-8
    • (2006) Horm Metab Res , vol.38 , pp. 423-428
    • Pratley, R.E.1    Jauffret-Kamel, S.2    Galbreath, E.3
  • 36
    • 33847687205 scopus 로고    scopus 로고
    • Vildagliptin in drug-naive patients with type 2 diabetes: A 24-week, double-blind, randomized, placebo-controlled, multiple-dose study
    • Dejager S, Razac S, Foley JE, et al. Vildagliptin in drug-naive patients with type 2 diabetes: a 24-week, double-blind, randomized, placebo-controlled, multiple-dose study. Horm Metab Res 2007-39:218-23
    • (2007) Horm Metab Res , pp. 218-223
    • Dejager, S.1    Razac, S.2    Foley, J.E.3
  • 37
    • 33846905487 scopus 로고    scopus 로고
    • Efficacy and tolerability of vildagliptin monotherapy in drug-naive patients with type 2 diabetes
    • Pi-Sunye FX, Schweizer A, Mills D, et al. Efficacy and tolerability of vildagliptin monotherapy in drug-naive patients with type 2 diabetes. Diabetes Res Clin Pract 2007; 76:132-8
    • (2007) Diabetes Res Clin Pract , vol.76 , pp. 132-138
    • Pi-Sunye, F.X.1    Schweizer, A.2    Mills, D.3
  • 38
    • 34548118796 scopus 로고    scopus 로고
    • Comparison between vildagliptin and metformin to sustain reductions in HbA(1c) over 1 year in drug-naive patients with Type 2 diabetes
    • Schweizer A, Couturier A, Foley JE, et al. Comparison between vildagliptin and metformin to sustain reductions in HbA(1c) over 1 year in drug-naive patients with Type 2 diabetes. Diabetic Med 2007;24:955-61
    • (2007) Diabetic Med , vol.24 , pp. 955-961
    • Schweizer, A.1    Couturier, A.2    Foley, J.E.3
  • 39
    • 33846694046 scopus 로고    scopus 로고
    • Comparison of vildagliptin and rosiglitazone monotherapy in patients with type 2 diabetes: A 24-week, double-blind, randomized trial
    • Rosenstock J, Baron MA, Dejager S, et al. Comparison of vildagliptin and rosiglitazone monotherapy in patients with type 2 diabetes: a 24-week, double-blind, randomized trial. Diabetes Care 2007;30:217-23
    • (2007) Diabetes Care , vol.30 , pp. 217-223
    • Rosenstock, J.1    Baron, M.A.2    Dejager, S.3
  • 40
    • 33846827085 scopus 로고    scopus 로고
    • Efficacy and tolerability of initial combination therapy with vildagliptin and pioglitazone compared with component monotherapy in patients with type 2 diabetes
    • Rosenstock J, Baron MA, Camisasca RP, et al. Efficacy and tolerability of initial combination therapy with vildagliptin and pioglitazone compared with component monotherapy in patients with type 2 diabetes. Diabetes Obes Metab 2007; 9:175-85
    • (2007) Diabetes Obes Metab , vol.9 , pp. 175-185
    • Rosenstock, J.1    Baron, M.A.2    Camisasca, R.P.3
  • 41
    • 34147093268 scopus 로고    scopus 로고
    • Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin
    • Bosi E, Camisasca RP, Collober C, et al. Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin. Diabetes Care 2007;30:890-5
    • (2007) Diabetes Care , vol.30 , pp. 890-895
    • Bosi, E.1    Camisasca, R.P.2    Collober, C.3
  • 42
    • 9444285818 scopus 로고    scopus 로고
    • Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes
    • Ahren B, Gomis R, Standl E, et al. Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes. Diabetes Care 2004; 27:2874-80
    • (2004) Diabetes Care , vol.27 , pp. 2874-2880
    • Ahren, B.1    Gomis, R.2    Standl, E.3
  • 43
    • 23044487247 scopus 로고    scopus 로고
    • Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year
    • Ahren B, Pacini G, Foley JE, et al. Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year. Diabetes Care 2005; 28:1936-40
    • (2005) Diabetes Care , vol.28 , pp. 1936-1940
    • Ahren, B.1    Pacini, G.2    Foley, J.E.3
  • 44
    • 33846828660 scopus 로고    scopus 로고
    • Vildagliptin in combination with pioglitazone improves glycaemic control in patients with type 2 diabetes failing thiazolidinedione monotherapy: A randomized, placebo-controlled study
    • Garber AJ, Schweizer A, Baron MA, et al. Vildagliptin in combination with pioglitazone improves glycaemic control in patients with type 2 diabetes failing thiazolidinedione monotherapy: a randomized, placebo-controlled study. Diabetes Obes Metab 2007;9:166-74
    • (2007) Diabetes Obes Metab , vol.9 , pp. 166-174
    • Garber, A.J.1    Schweizer, A.2    Baron, M.A.3
  • 45
    • 18244397429 scopus 로고    scopus 로고
    • Food for thought: Endocannabinoid modulation of lipogenesis
    • Lichtman AH, Cravatt BF. Food for thought: endocannabinoid modulation of lipogenesis. J Clin Invest 2005;115:1130-3
    • (2005) J Clin Invest , vol.115 , pp. 1130-1133
    • Lichtman, A.H.1    Cravatt, B.F.2
  • 46
    • 21644468930 scopus 로고    scopus 로고
    • The endocannabinoid system: A new therapeutic target for cardiovascular risk factor management
    • Finer N, Pagotto U. The endocannabinoid system: a new therapeutic target for cardiovascular risk factor management. Br J Diabetes Vasc Dis 2005;5:121-4
    • (2005) Br J Diabetes Vasc Dis , vol.5 , pp. 121-124
    • Finer, N.1    Pagotto, U.2
  • 47
    • 27844463517 scopus 로고    scopus 로고
    • Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia
    • Despres JP, Golay A, Sjostrom L. Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. New Engl J Med 2005;353:2121-34
    • (2005) New Engl J Med , vol.353 , pp. 2121-2134
    • Despres, J.P.1    Golay, A.2    Sjostrom, L.3
  • 49
    • 50149117733 scopus 로고    scopus 로고
    • New data shows Acomplia (rimonabant) benefited patients with type 2 diabetes by improving blood sugar control, reducing weight and acting on other cardiometabolic risk factors. Available at: http://en.sanofi-aventis.com/press/ppc-14733.asp [last accessed May 15, 2008]
    • New data shows Acomplia (rimonabant) benefited patients with type 2 diabetes by improving blood sugar control, reducing weight and acting on other cardiometabolic risk factors. Available at: http://en.sanofi-aventis.com/press/ppc-14733.asp [last accessed May 15, 2008]
  • 50
    • 33751001942 scopus 로고    scopus 로고
    • Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: A randomised controlled study
    • Scheen AJ, Finer N, Hollander P, et al. Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study. Lancet 2006;368:1660-72
    • (2006) Lancet , vol.368 , pp. 1660-1672
    • Scheen, A.J.1    Finer, N.2    Hollander, P.3
  • 51
    • 32044464960 scopus 로고    scopus 로고
    • Activation of cannabinoid CB1 receptors induces glucose intolerance in rats
    • Bermudez-Siva FJ, Serrano A, Diaz-Molina FJ, et al. Activation of cannabinoid CB1 receptors induces glucose intolerance in rats. Eur J Pharmacol 2006;531:282-4
    • (2006) Eur J Pharmacol , vol.531 , pp. 282-284
    • Bermudez-Siva, F.J.1    Serrano, A.2    Diaz-Molina, F.J.3
  • 52
    • 33846018374 scopus 로고    scopus 로고
    • Does rimonabant pull its weight for type 2 diabetes?
    • Cleland SJ, Sattar N. Does rimonabant pull its weight for type 2 diabetes? Lancet 2006;368:1632-4
    • (2006) Lancet , vol.368 , pp. 1632-1634
    • Cleland, S.J.1    Sattar, N.2
  • 53
    • 36048995288 scopus 로고    scopus 로고
    • Efficacy and safety of the weight-loss drug rimonabant: A meta-analysis of randomised trials
    • Christensen R, Kristensen PK, Bartels EM, et al. Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials. Lancet 2007;370:1706-13
    • (2007) Lancet , vol.370 , pp. 1706-1713
    • Christensen, R.1    Kristensen, P.K.2    Bartels, E.M.3
  • 54
    • 33645098531 scopus 로고    scopus 로고
    • Clinical utility of bile acid sequestrants in the treatment of dyslipidemia: A scientific review
    • Insull Jr W. Clinical utility of bile acid sequestrants in the treatment of dyslipidemia: a scientific review. South Med J 2006; 99:257-73
    • (2006) South Med J , vol.99 , pp. 257-273
    • Insull Jr, W.1
  • 55
    • 0141866661 scopus 로고    scopus 로고
    • Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle
    • De Fabiani E, Mitro N, Gilardi F, et al. Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle. J Biol Chem 2003;278:39124-32
    • (2003) J Biol Chem , vol.278 , pp. 39124-39132
    • De Fabiani, E.1    Mitro, N.2    Gilardi, F.3
  • 56
    • 33750522053 scopus 로고    scopus 로고
    • Blood glucose-lowering activity of colestimide in patients with type 2 diabetes and hypercholesterolemia: A case-control study comparing colestimide with acarbose
    • Suzuki T, Oba K, Futami S, et al. Blood glucose-lowering activity of colestimide in patients with type 2 diabetes and hypercholesterolemia: a case-control study comparing colestimide with acarbose. J Nippon Med Sch 2006;73:277-84
    • (2006) J Nippon Med Sch , vol.73 , pp. 277-284
    • Suzuki, T.1    Oba, K.2    Futami, S.3
  • 57
    • 2542435874 scopus 로고    scopus 로고
    • Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxol
    • Yamagata K, Daitoku H, Shimamoto Y, et al. Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxol. J Biol Chem 2004;279:23158-65
    • (2004) J Biol Chem , vol.279 , pp. 23158-23165
    • Yamagata, K.1    Daitoku, H.2    Shimamoto, Y.3
  • 58
    • 0016748143 scopus 로고
    • Hypocholesterolemic activity of colestipol in diabetes
    • Bandisocle MS, Boshell BR. Hypocholesterolemic activity of colestipol in diabetes. Curr Ther Res Clin Exp 1975;18:276-84
    • (1975) Curr Ther Res Clin Exp , vol.18 , pp. 276-284
    • Bandisocle, M.S.1    Boshell, B.R.2
  • 59
    • 0017770543 scopus 로고
    • Colestipol by hypercholesteremia in diabetics]
    • Duntsch G. [Colestipol by hypercholesteremia in diabetics]. Fortschr Med 1977;95:1492-6
    • (1977) Fortschr Med , vol.95 , pp. 1492-1496
    • Duntsch, G.1
  • 60
    • 0028575639 scopus 로고
    • Cholestyramine therapy for dyslipidemia in non-insulin-dependent diabetes mellitus. A short-term, double-blind, crossover trial
    • Garg A, Grundy SM. Cholestyramine therapy for dyslipidemia in non-insulin-dependent diabetes mellitus. A short-term, double-blind, crossover trial. Ann Intern Med 1994;121:416-22
    • (1994) Ann Intern Med , vol.121 , pp. 416-422
    • Garg, A.1    Grundy, S.M.2
  • 61
    • 0033673164 scopus 로고    scopus 로고
    • Additive effects of simvastatin beyond its effects on LDL-cholesterol in hypertensive type 2 diabetic patients
    • Tonolo G, Melis MG, Formato M, et al. Additive effects of simvastatin beyond its effects on LDL-cholesterol in hypertensive type 2 diabetic patients. Eur J Clin Invest 2000; 30:980-7
    • (2000) Eur J Clin Invest , vol.30 , pp. 980-987
    • Tonolo, G.1    Melis, M.G.2    Formato, M.3
  • 62
    • 33947610582 scopus 로고    scopus 로고
    • Effect of colestimide therapy for glycemic control in type 2 diabetes mellitus with hypercholesterolemia
    • Yamakawa T, Takano T, Utsunomiya H, et al. Effect of colestimide therapy for glycemic control in type 2 diabetes mellitus with hypercholesterolemia. Endocr J 2007;54:53-8
    • (2007) Endocr J , vol.54 , pp. 53-58
    • Yamakawa, T.1    Takano, T.2    Utsunomiya, H.3
  • 63
    • 33947120281 scopus 로고    scopus 로고
    • Results of the glucose-lowering effect of WelChol study (GLOWS): A randomized, double-blind, placebo-controlled pilot study evaluating the effect of colesevelam hydrochloride on glycemic control in subjects with type 2 diabetes
    • Zieve FJ, Kalin MF, Schwartz SL, et al. Results of the glucose-lowering effect of WelChol study (GLOWS): a randomized, double-blind, placebo-controlled pilot study evaluating the effect of colesevelam hydrochloride on glycemic control in subjects with type 2 diabetes. Clin Ther 2007;29:74-83
    • (2007) Clin Ther , vol.29 , pp. 74-83
    • Zieve, F.J.1    Kalin, M.F.2    Schwartz, S.L.3
  • 64
    • 0037797108 scopus 로고    scopus 로고
    • Colesevelam HCl a non-systemic lipid-altering drug
    • Bays H, Dujovne C. Colesevelam HCl a non-systemic lipid-altering drug. Expert Opin Pharmacother 2003;4:779-90
    • (2003) Expert Opin Pharmacother , vol.4 , pp. 779-790
    • Bays, H.1    Dujovne, C.2
  • 65
    • 0033731362 scopus 로고    scopus 로고
    • In vitro comparison of bile acid binding to colesevelarn HCl and other bile acid sequestrants
    • Braunlin W, Zhorov E, Smisek D. In vitro comparison of bile acid binding to colesevelarn HCl and other bile acid sequestrants. Polymer Preprints; 2000;41:708-9
    • (2000) Polymer Preprints , vol.41 , pp. 708-709
    • Braunlin, W.1    Zhorov, E.2    Smisek, D.3
  • 67
    • 34547150134 scopus 로고    scopus 로고
    • Rationale and design of a prospective clinical trial program to evaluate the glucose-lowering effects of colesevelam HCl in patients with type 2 diabetes mellitus
    • Bays HE, Cohen DE. Rationale and design of a prospective clinical trial program to evaluate the glucose-lowering effects of colesevelam HCl in patients with type 2 diabetes mellitus. Curr Med Res Opin 2007;23:1673-84
    • (2007) Curr Med Res Opin , vol.23 , pp. 1673-1684
    • Bays, H.E.1    Cohen, D.E.2
  • 69
    • 33846637891 scopus 로고    scopus 로고
    • Metabolic effects of subchronic ablation of the incretin receptors by daily administration of (Pro3)GIP and exendin(9-39)amide in obese diabetic (ob/ob) mice
    • Parker JC, Irwin N, Lavery KS, et al. Metabolic effects of subchronic ablation of the incretin receptors by daily administration of (Pro3)GIP and exendin(9-39)amide in obese diabetic (ob/ob) mice. Biol Chem 2007;388:221-6
    • (2007) Biol Chem , vol.388 , pp. 221-226
    • Parker, J.C.1    Irwin, N.2    Lavery, K.S.3
  • 70
    • 34249941340 scopus 로고    scopus 로고
    • Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice
    • Irwin N, McClean PL, O'Harte F P, et al. Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice. Diabetologia 2007;50:1532-40
    • (2007) Diabetologia , vol.50 , pp. 1532-1540
    • Irwin, N.1    McClean, P.L.2    O'Harte, F.P.3
  • 71
    • 0037103769 scopus 로고    scopus 로고
    • The Src-family tyrosine kinase inhibitor PP1 interferes with the activation of ribosomal protein S6 kinases
    • Shah OJ, Kimball SR, Jefferson LS. The Src-family tyrosine kinase inhibitor PP1 interferes with the activation of ribosomal protein S6 kinases. Biochem J 2002;366:57-62
    • (2002) Biochem J , vol.366 , pp. 57-62
    • Shah, O.J.1    Kimball, S.R.2    Jefferson, L.S.3
  • 72
    • 24144446404 scopus 로고    scopus 로고
    • Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability
    • Tremblay F, Krebs M, Dombrowski L, et al. Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. Diabetes 2005;54:2674-84
    • (2005) Diabetes , vol.54 , pp. 2674-2684
    • Tremblay, F.1    Krebs, M.2    Dombrowski, L.3
  • 73
    • 0037238379 scopus 로고    scopus 로고
    • Effects of the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes
    • Andrews RC, Rooyackers O, Walker BR. Effects of the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes. J Clin Endocrinol Metab 2003;88:285-91
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 285-291
    • Andrews, R.C.1    Rooyackers, O.2    Walker, B.R.3
  • 74
    • 50149086496 scopus 로고    scopus 로고
    • Metabolic effects of 14-day treatment with DIO-902: Results of a randomized, placebo-controlled trial in patients with type 2 diabetes
    • Chicago, IL, June 22-26
    • Schwartz S, Rendell M, Ahmann A, et al. Metabolic effects of 14-day treatment with DIO-902: results of a randomized, placebo-controlled trial in patients with type 2 diabetes, 67th Annual American Diabetes Association Scientific Sessions, Chicago, IL, June 22-26, 2007
    • (2007) 67th Annual American Diabetes Association Scientific Sessions
    • Schwartz, S.1    Rendell, M.2    Ahmann, A.3
  • 75
    • 18044388740 scopus 로고    scopus 로고
    • Small molecule glucokinase activators as novel anti-diabetic agents
    • Leighton B, Atkinson A, Coghlan MP. Small molecule glucokinase activators as novel anti-diabetic agents. Biochem Soc Trans 2005-133:371-4
    • Biochem Soc Trans , vol.2005 -133 , pp. 371-374
    • Leighton, B.1    Atkinson, A.2    Coghlan, M.P.3
  • 76
    • 0037317489 scopus 로고    scopus 로고
    • PTP1B inhibitors as potential therapeutics in the treatment of type 2 diabetes and obesity
    • Zhang ZY, Lee SY. PTP1B inhibitors as potential therapeutics in the treatment of type 2 diabetes and obesity. Expert Opin Investig Drugs 2003;12:223-33
    • (2003) Expert Opin Investig Drugs , vol.12 , pp. 223-233
    • Zhang, Z.Y.1    Lee, S.Y.2
  • 78
    • 50149092150 scopus 로고    scopus 로고
    • A double-blind randomized repeat dose study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of three times daily dosing of sergliflozin, a novel inhibitor of renal glucose reabsorption
    • Chicago, IL, June 22-26
    • Hussey EK, Dobbins RL, Stolz RR, et al. A double-blind randomized repeat dose study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of three times daily dosing of sergliflozin, a novel inhibitor of renal glucose reabsorption, in healthy, overweight and obese subjects, 67th Annual American Diabetes Association Scientific Sessions, Chicago, IL, June 22-26, 2007
    • (2007) healthy, overweight and obese subjects, 67th Annual American Diabetes Association Scientific Sessions
    • Hussey, E.K.1    Dobbins, R.L.2    Stolz, R.R.3
  • 79
    • 33748286778 scopus 로고    scopus 로고
    • Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats
    • van Poelje PD, Potter SC, Chandramouli VC, et al. Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats. Diabetes 2006;55:1747-54
    • (2006) Diabetes , vol.55 , pp. 1747-1754
    • van Poelje, P.D.1    Potter, S.C.2    Chandramouli, V.C.3
  • 80
    • 50149091065 scopus 로고    scopus 로고
    • CS-917, a fructose 1,6-bisphosphate inhibitor, suppresses gluconeogenesis in human hepatocytes, whereas metformin stimulates glycolysis in Caco-2 cells
    • Chicago, IL, June 22-26
    • Okuno A, Takahashi K, Tanaka J, et al. CS-917, a fructose 1,6-bisphosphate inhibitor, suppresses gluconeogenesis in human hepatocytes, whereas metformin stimulates glycolysis in Caco-2 cells, 67th Annual American Diabetes Association Scientific Sessions, Chicago, IL, June 22-26, 2007
    • (2007) 67th Annual American Diabetes Association Scientific Sessions
    • Okuno, A.1    Takahashi, K.2    Tanaka, J.3
  • 81
    • 50149115753 scopus 로고    scopus 로고
    • MB06322 (CS-917), but not metformin, lowers blood glucose by inhibiting gluconeogenesis in Zucker diabetic fatty rats
    • Chicago, IL, June 22-26
    • Van Poelje PD, Potter SC, Haughey MP, et al. MB06322 (CS-917), but not metformin, lowers blood glucose by inhibiting gluconeogenesis in Zucker diabetic fatty rats, 67th Annual American Diabetes Association Scientific Sessions, Chicago, IL, June 22-26, 2007
    • (2007) 67th Annual American Diabetes Association Scientific Sessions
    • Van Poelje, P.D.1    Potter, S.C.2    Haughey, M.P.3


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