Practical application of CellML 1.1: The integration of new mechanisms into a human ventricular myocyte model

Progress in Biophysics and Molecular Biology

Volumn 98, Issue 1, 2008, Pages 38-51

  Nickerson, David ^a   Buist, Martin ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Cardiac cellular electrophysiology; Cardiac ischemia; CellML; Mathematical model description; Model exchange

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; CALCIUM CHANNEL; POTASSIUM; SODIUM CALCIUM EXCHANGE PROTEIN;

BIOLOGICAL MODEL; BIOLOGY; CHEMISTRY; COMPUTER PROGRAM; COMPUTER SIMULATION; CYTOLOGY; HEART ATRIUM; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HUMAN; METABOLISM; METHODOLOGY; PATHOLOGY; REVIEW; THEORETICAL MODEL;

ADENOSINE TRIPHOSPHATE; CALCIUM; CALCIUM CHANNELS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; HEART ATRIA; HUMANS; MODELS, BIOLOGICAL; MODELS, THEORETICAL; MYOCARDIAL ISCHEMIA; MYOCYTES, CARDIAC; POTASSIUM; SODIUM-CALCIUM EXCHANGER; SOFTWARE;

EID: 50049131641     PISSN: 00796107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbiomolbio.2008.05.006     Document Type: Review

References (27)

1. Berners-Lee, T., Fielding, R., Masinter, L., 2005. Rfc 3986, uniform resource identifier (uri): Generic syntax. .
2. Carmeliet E. Cardiac ionic currents and acute ischaemia: from channels to arrhythmias. Physiol. Rev. 79 3 (1999) 917-1017
3. Clancy C.E., and Rudy Y. Na(+) channel mutation that causes both brugada and long-qt syndrome phenotypes: a simulation study of mechanism. Circulation 105 10 (2002) 1208-1213
4. Cuellar A.A., Lloyd C.M., Nielson P.F., Halstead M.D.B., Bullivant D.P., Nickerson D.P., and Hunter P.J. An overview of CellML 1.1, a biological model description language. Simulation 79 12 (2003) 740-747
5. Cuellar, A.A., Nelson, M.R., Hedley, W.H., 2006a. CellML Metadata 1.0 Specification. .
6. Cuellar, A.A., Nielsen, P.F., Halstead, M.D.B., Bullivant, D.P., Nickerson, D.P., Hedley, W.H., Nelson, M.R., Lloyd, C.M., 2006b. CellML 1.1 Specification. .
7. + channel modification by metabolic inhibition in isolated guinea-pig ventricular myocytes. J. Physiol. 465 (1993) 163-179
8. Doering A.E., and Lederer W.J. The mechanism by which cytoplasmic protons inhibit the sodium-calcium exchanger in guinea-pig heart cells. J. Physiol. 466 (1993) 481-499
9. Doering A.E., and Lederer W.J. The action of Na+ as a cofactor in the inhibition by cytoplasmic protons of the cardiac Na(+)-Ca2+ exchanger in the guinea-pig. J. Physiol. 480 Pt 1 (1994) 9-20
10. Haworth R.A., and Goknur A.B. ATP dependence of calcium uptake by the Na-Ca exchanger of adult heart cells. Circ. Res. 71 1 (1992) 210-217
11. Hedley W.J., Nelson M.R., Bullivant D.P., and Nielsen P.F. A short introduction to CellML. Philos. Trans. Royal Soc. A: Math., Phys. Eng. Sci. 359 1783 (2001) 1073-1089. http://dx.doi.org/10.1098/rsta.2001.0817
12. Henderson I.M., Starling A.P., Wictome M., East J.M., and Lee A.G. Binding of Ca2+ to the (Ca(2+)-Mg2+)-atpase of sarcoplasmic reticulum: kinetic studies. Biochem. J. 297 Pt 3 (1994) 625-636
13. + channels in myocardial ischemia. Jpn. Heart J. 38 3 (1997) 297-315
14. Irisawa H., and Sato R. Intra- and extracellular actions of proton on the calcium current of isolated guinea pig ventricular cells. Circ. Res. 59 3 (1986) 348-355
15. Ito H., Vereecke J., and Carmeliet E. Intracellular protons inhibit inward rectifier K+ channel of guinea-pig ventricular cell membrane. Pflugers Arch. 422 (1992) 280-286
16. 2+ dynamics: the roles of ryanodine receptor adaptation and sarcoplasmic reticulum load. Biophys. J. 74 3 (1998) 1149-1168
17. Kaibara M., and Kameyama M. Inhibition of the calcium channel by intracellular protons in single ventricular myocytes of the guinea-pig. J. Physiol. 403 (1988) 621-640
18. Luo C.H., and Rudy Y. A dynamic model of the cardiac ventricular action potential. i. Simulations of ionic currents and concentration changes. Circ. Res. 74 6 (1994) 1071-1096
19. Matsuoka S., Sarai N., Kuratomi S., Ono K., and Noma A. Role of individual ionic current systems in ventricular cells hypothesized by a model study. Jpn. J. Physiol. 53 (2003) 105-123
20. Nichols C.G., Ripoll C., and Lederer W.J. ATP-sensitive potassium channel modulation of the guinea pig ventricular action potential and contraction. Circ. Res. 68 1 (1991) 280-287
21. Nickerson D.P., and Hunter P.J. The noble cardiac ventricular electrophysiology models in CellML. Prog. Biophys. Mol. Biol. 90 (2006) 346-359
22. Nickerson D.P., Nash M.P., Nielsen P.F., Smith N.P., and Hunter P.J. Computational multiscale modeling in the IUPS Physiome Project: modeling cardiac electromechanics. IBM J. Res. Dev. 50 6 (2006) 617-630
23. Noble D. The voltage dependence of the cardiac membrane conductance. Biophys. J. 2 (1962) 381-393
24. + channels in cardiac muscle. Nature 305 (1983) 147-148
25. Shaw R.M., and Rudy Y. Electrophysiologic effects of acute myocardial ischemia: a theoretical study of altered cell excitability and action potential duration. Cardiovasc. Res. 35 (1997) 256-272
26. ten Tusscher K.H.W.J., Noble D., Noble P.J., and Panfilov A.V. A model for human ventricular tissue. Am. J. Physiol. Heart Circ. Physiol. 286 4 (2004) H1573-H1589
27. Xu L., Mann G., and Meissner G. Regulation of cardiac Ca2+ release channel (ryanodine receptor) by Ca2+, H+, Mg2+, and adenine nucleotides under normal and simulated ischemic conditions. Circ. Res. 79 6 (1996) 1100-1109. http://circres.ahajournals.org/cgi/content/abstract/79/6/1%20100