The effects of cryptorchidism on the regulation of steroidogenesis and gap junctional communication in equine testes

Endokrynologia Polska

Volumn 59, Issue 2, 2008, Pages 112-118

  Hejmej, Anna ^a   Bilińska, Barbara ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

Connexin43; Cryptorchidism; Immunohistochemistry; Stallion; Steroidogenesis

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; ANDROGEN; AROMATASE; CONNEXIN 43; ESTRADIOL; ESTROGEN; LUTEINIZING HORMONE RECEPTOR; STEROID HORMONE; TESTOSTERONE;

ANIMAL CELL; ANIMAL TISSUE; AROMATIZATION; ARTICLE; CELL COMMUNICATION; CELL FUNCTION; CONTROLLED STUDY; CRYPTORCHISM; DISEASE ASSOCIATION; ENDOCRINE DISEASE; GAP JUNCTION; HORMONE SYNTHESIS; HORSE; IMMUNOHISTOCHEMISTRY; INTERSTITIUM; LEYDIG CELL; MALE; MALE INFERTILITY; NONHUMAN; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; SEMINIFEROUS TUBULE; SIGNAL TRANSDUCTION; SPERMATOGENESIS; STALLION; STEROIDOGENESIS; SUBFERTILITY; TESTIS CELL; TISSUE HOMOGENATE; ANIMAL; BIOSYNTHESIS; CELL JUNCTION; GENE EXPRESSION; METABOLISM;

3-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; AROMATASE; CONNEXIN 43; CRYPTORCHIDISM; ESTRADIOL; GAP JUNCTIONS; GENE EXPRESSION; HORSES; LEYDIG CELLS; MALE; RECEPTORS, LH; SPERMATOGENESIS; TESTOSTERONE;

EID: 50049106292     PISSN: 0423104X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Pinart E, Sancho S, Briz MD et al. Ultrastructural study of the boar seminiferous epithelium: changes in cryptorchidism. J Morphol 2000; 244: 190-202.
2. Pinart E, Bonet S, Briz M et al. Histochemical study of the interstitial tissue in scrotal and abdominal boar testes, Vet J 2002; 163: 68-76.
3. Huff DS, Fenig DM, Canning DA et al. Abnormal germ cell development in cryptorchidism. Horm Res 2001; 55: 11-17.
4. Kotula-Balak M, Wojciechowska J, Bilińska B. The site of aromatization in the mouse cryptorchid testis. Folia Biol (Krakow) 2001; 49: 279-283.
5. Kaleva M, Toppari J. Cryptorchidism: an indicator of testicular dysgenesis? Cell Tissue Res 2005; 322: 167-171
6. Virtanen HE, Bjerknes R, Cortes D et al. Cryptorchidism: classification, prevalence and long-term consequences. Acta Paediatr 2007; 96: 611-616.
7. Bergh A, Söder O. Studies of cryptorchidism in experimental animal models. Acta Paediatr 2007; 96: 617-621.
8. Searle D, Dart AJ, Dart CM et al. Equine castration: review of anatomy, approaches, techniques and complications in normal, cryptorchid and monorchid horses. Aust Vet J 1999; 77: 428-34.
9. Smolen AJ. Image analytic techniques for quantification of immunocytochemical staining in the nervous system. In: Conn PM (ed.). Methods in Neurosciences. Academic Press, San Diego 1990; 208-229.
10. Dufau ML, Catt KJ, Tsuruhara T et al. Radioimmunoassay of plasma testosterone. Clin Chim Acta 1972; 37: 109-116.
11. Hotchkiss J, Atkinson LE, Knobil E. Time course of serum estrogen and luteinizing hormone (LH) concentrations during the menstrual cycle of the rhesus monkey. Endocrinology 1971; 89: 177-183.
12. Ascoli M, Fanelli F, Segaloff DL. The lutropin/choriogonadotropin receptor, a 2002 perspective. Endocr Rev 2002; 23: 141-174.
13. Huhtaniemi I, Bergh A, Nikula H et al. Differences in the regulation of steroidogenesis and tropic hormone receptors between the scrotal and abdominal testes of unilaterally cryptorchid adult rats. Endocrinology 1984; 115: 550-155.
14. Hovatta O, Huhtaniemi I, Wahlstrom T. Testicular gonadotrophins and their receptors in human cryptorchidism as revealed by immunohistochemistry and radioreceptor assay. Acta Endocrinol (Copenh) 1986; 111: 128-132.
15. Tena-Sempere M, Kero J, Rannikko A et al. Experimental cryptorchidism induces a change in the pattern of expression of LH receptor mRNA in rat testis after selective Leydig cell destruction by ethylene dimethane sulfonate. J Endocrinol 1999; 161: 131-141.
16. Wisner JR Jr, Gomes WR. Influence of experimental cryptorchidism on cholesterol side-chain cleavage enzyme and delta5-3beta-hydroxysteroid dehydrogenase activities in rat testes. Steroids 1978, 31: 189-203.
17. Bilińska B, Kotula-Balak M, Gancarczyk M et al. Androgen aromatization in cryptorchid mouse testis. Acta Histochem 2003; 105: 57-165.
18. Illera JC, Silvan G, Munro CJ et al. Amplified androstenedione enzyme-immunoassay for the diagnosis of cryptorchidism in the male horse: comparison with testosterone and estrone sulphate methods. J Steroid Biochem Mol Biol 2003; 84: 377-382
19. Kawakami E, Hori T, Tsutsui T. Function of contralateral testis after artificial unilateral cryptorchidism in dogs. J Vet Med Sci 1999; 61:1107-1111.
20. Ryan PL, Friendship RM, Raeside JI. Impaired estrogen production by Leydig cells of the naturally retained testis in unilaterally cryptorchid boars and stallions. J Androl 1986; 7: 100-104.
21. Ren L, Medan MS, Ozu M et al. Effects of experimental cryptorchidism on sperm motility and testicular endocrinology in adult male rats. J Reprod Dev 2006; 52: 219-228.
22. Lei ZM, Mishra S, Ponnuru P et al. Testicular phenotype in luteinizing hormone receptor knockout animals and the effect of testosterone replacement therapy. Biol Reprod 2004; 71: 1605-1613.
23. O'Donnell L, Robertson KM, Jones ME et al. Estrogen and spermatogenesis. Endocr Rev 2001; 22: 289-318.
24. Hess RA. Estrogen in the adult male reproductive tract: a review. Reprod Biol Endocrinol 2003; 1: 52.
25. Toyama Y, Hosoi I, Ichikawa S et al. b-estradiol 3-benzoate affects spermatogenesis in the adult mouse. Mol Cell Endocrinol 2001; 178:161-168.
26. Gancarczyk M, Paziewska-Hejmej A, Carreau S et al. Dose- and photoperiod-dependent effects of 17beta-estradiol and the anti-estrogen ICI 182,780 on testicular structure, acceleration of spermatogenesis, and aromatase immunoexpression in immature bank voles. Acta Histochem 2004; 106: 269-278
27. Williams K, McKinnell C, Saunders PT et al. Neonatal exposure to potent and environmental oestrogens and abnormalities of the male reproductive system in the rat: evidence for importance of androgen-oestrogen balance and assessment of the relevance to man. Hum Reprod Update 2001; 7: 236-247.
28. Pointis G, Fiorini C, Defamie N et al. Gap junctional communication in the male reproductive system. Biochim Biophys Acta 2005; 1719: 102-116.
29. Steger K, Tetens F, Bergmann M. Expression of connexin 43 in human testis. Histochem Cell Biol 1999; 112: 215-220.
30. Batias C, Defamie N, Lablack A et al. Modified expression of testicular gap-junction connexin 43 during normal spermatogenic cycle and in altered spermatogenesis. Cell Tissue Res 1999; 298: 113-121.
31. Risley MS, Tan IP, Roy C et al. Cell, age- and stage-dependent distribution of connexin43 gap junctions in testes. J Cell Sci 1992; 103: 81-96.
32. Batias C, Siffroi JP, Fenichel P et al. Connexin43 gene expression and regulation in the rodent seminiferous epithelium. J Histochem Cytochem 2000; 48: 793-805.
33. Fiorini C, Tilloy-Ellul A, Chevalier S et al. Sertoli cell junctional proteins as early targets for different classes of reproductive toxicants. Reprod Toxicol 2004; 18: 413-421.
34. Defamie N, Berthaut I, Mograbi B et al. Impaired gap junction connexin43 in Sertoli cells of patients with secretory azoospermia: a marker of undifferentiated Sertoli cells. Lab Invest 2003; 83: 449-456.
35. Kahiri CN, Khalil MW, Tekpetey F et al. Leydig cell function in mice lacking connexin43. Reproduction 2006; 132: 607-616.
36. Segretain D, Decrouy X, Dompierre J et al. Sequestration of connexin43 in the early endosomes: an early event of Leydig cell tumor progression. Mol Carcinog 2003; 38: 179-187.