Liquid chromatography/electrospray ionization tandem mass spectrometry for the quantification of mitiglinide in human plasma: Validation and its application to pharmacokinetic studies

Biomedical Chromatography

Volumn 22, Issue 8, 2008, Pages 873-878

  Zhang, Yan ^a,b   Ding, Likun ^a   Tian, Yun ^a   Yang, Jing ^a   Yang, Lin ^a   Wen, Aidong ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

HPLC MS MS; Mitiglinide; Pharmacokinetics

Indexed keywords

ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONS; MASS SPECTROMETERS; MASS SPECTROMETRY; PLASMA (HUMAN);

AGILENT; ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY; HPLC-MS-MS; HUMAN PLASMAS; LIQUID CHROMATOGRAPHY ELECTROSPRAY; MITIGLINIDE; PHARMACOKINETIC STUDIES; PRECURSOR IONS; PRODUCT IONS; RELATIVE STANDARDS DEVIATIONS;

PHARMACOKINETICS;

ACETIC ACID ETHYL ESTER; AMMONIUM ACETATE; METHANOL; MITIGLINIDE;

ACCURACY; ADULT; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; CONTROLLED STUDY; DRUG DETERMINATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; FLOW RATE; HUMAN; LIQUID CHROMATOGRAPHY; MALE; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; STRUCTURE ANALYSIS; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

EID: 50049089834     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1005     Document Type: Article

References (6)

1. DHHS/FDA/CDER. Guidance for Industry, Bioanalytical Method Validation. US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, May 2001.
2. Liang Y, Sun J, Xie L, Kang A, Xie Y, Chen WD, Lv H and Wang GJ. Simple, sensitive, and rapid LC-ESI-MS method for quantification of mitiglinide in human urine. Chromatographia 2007; 66: 165.
3. Ojima K, Kiyono Y and Kojima M. Pharmacological and clinical profile of mitiglinide calcium hydrate (Glufast), a new insulinotropic agent with rapid onset. Nippon Yakurigaku Zasshi 2004; 124: 245-255.
4. Reimann F, Proks P and Ashcroft FM. Effect of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and on Kir6.2/SUR2B types of ATP-sensitive potassium channel. British Journal of Pharmacology 2001; 132: 1542.
5. + channels and insulin secretion: comparison with the sulfonylureas and nateglinide. European Journal of Pharmacology 2001; 431: 119.
6. Yu L and Zeng S. Determination of mitiglinide in rat plasma by high-performance liquid chromatography with UV detection. Journal of Chromatography B 2006; 834: 204.