The LIM protein LIMD1 influences osteoblast differentiation and function

Experimental Cell Research

Volumn 314, Issue 15, 2008, Pages 2884-2894

  Luderer, Hilary F ^a   Bai, Shuting ^a   Longmore, Gregory D ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

LIM proteins; Limd1; Mesenchymal stem cells; Osteoblast; Osteoprogenitors; Wnt signaling; catenin

Indexed keywords

BETA CATENIN; LIM PROTEIN; NUCLEIC ACID BINDING PROTEIN; PROTEIN LIMD1; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; BONE MINERALIZATION; CELL COUNT; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; IN VITRO STUDY; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

MUS;

EID: 50049085189     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2008.06.003     Document Type: Article

References (25)

1. Roodman G.D. Regulation of osteoclast differentiation. Ann. N. Y. Acad. Sci. 1068 (2006) 100-109
2. Rogers A., and Eastell R. Circulating osteoprotegerin and receptor activator for nuclear factor kappaB ligand: clinical utility in metabolic bone disease assessment. J. Clin. Endocrinol. Metab. 90 (2005) 6323-6331
3. Kiss H., Kedra D., Yang Y., Kost-Alimova M., Kiss C., O'Brien K.P., Fransson I., Klein G., Imreh S., and Dumanski J.P. A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3. Hum. Genet. 105 (1999) 552-559
4. Crawford A.W., and Beckerle M.C. Purification and characterization of zyxin, an 82,000-dalton component of adherens junctions. J. Biol. Chem. 266 (1991) 5847-5853
5. Petit M.M., Mols R., Schoenmakers E.F., Mandahl N., and Van de Ven W.J. LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. Genomics 36 (1996) 118-129
6. Yi J., and Beckerle M.C. The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis. Genomics 49 (1998) 314-316
7. Goyal R.K., Lin P., Kanungo J., Payne A.S., Muslin A.J., and Longmore G.D. Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner. Mol. Cell. Biol. 19 (1999) 4379-4389
8. Srichai M.B., Konieczkowski M., Padiyar A., Konieczkowski D.J., Mukherjee A., Hayden P.S., Kamat S., El-Meanawy M.A., Khan S., Mundel P., Lee S.B., Bruggeman L.A., Schelling J.R., and Sedor J.R. A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus. J. Biol. Chem. 279 (2004) 14398-14408
9. Kadrmas J.L., and Beckerle M.C. The LIM domain: from the cytoskeleton to the nucleus. Nat. Rev. Mol. Cell. Biol. 5 (2004) 920-931
10. Wilson S.G., Reed P.W., Bansal A., Chiano M., Lindersson M., Langdown M., Prince R.L., Thompson D., Thompson E., Bailey M., Kleyn P.W., Sambrook P., Shi M.M., and Spector T.D. Comparison of genome screens for two independent cohorts provides replication of suggestive linkage of bone mineral density to 3p21 and 1p36. Am. J. Hum. Genet. 72 (2003) 144-155
11. Feng Y., Zhao H., Luderer H.F., Epple H., Ross F.P., Teitelbaum S.L., and Longmore G.D. The LIM protein, LIMD1, regulates AP-1 activation through an interaction with TRAF6 to influence osteoclast development. J. Biol. Chem. (2006)
12. Feng Y., and Longmore G.D. The LIM protein Ajuba influences interleukin-1-induced NF-kB activation by affecting the assembly and activity of the protein kinase Cz/p62/TRAF6 signaling complex. MCB 21 (2005)
13. Semerad C.L., Christopher M.J., Liu F., Short B., Simmons P.J., Winkler I., Levesque J.P., Chappel J., Ross F.P., and Link D.C. G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow. Blood 106 (2005) 3020-3027
14. Takahashi N., Akatsu T., Udagawa N., Sasaki T., Yamaguchi A., Moseley J.M., Martin T.J., and Suda T. Osteoblastic cells are involved in osteoclast formation. Endocrinology 123 (1988) 2600-2602
15. Castro C.H., Shin C.S., Stains J.P., Cheng S.L., Sheikh S., Mbalaviele G., Szejnfeld V.L., and Civitelli R. Targeted expression of a dominant-negative N-cadherin in vivo delays peak bone mass and increases adipogenesis. J. Cell. Sci. 117 (2004) 2853-2864
16. Haraguchi K., Ohsugi M., Abe Y., Semba K., Akiyama T., and Yamamoto T. Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3beta-mediated phosphorylation of beta-catenin. Oncogene (2007)
17. Church V.L., and Francis-West P. Wnt signalling during limb development. Int. J. Dev. Biol. 46 (2002) 927-936
18. Logan C.Y., and Nusse R. The Wnt signaling pathway in development and disease. Annu. Rev. Cell. Dev. Biol. 20 (2004) 781-810
19. Zubler R.H. Ex vivo expansion of hematopoietic stem cells and gene therapy development. Swiss. Med. Wkly. 136 (2006) 795-799
20. Liu F., Kohlmeier S., and Wang C.Y. Wnt signaling and skeletal development. Cell Signal (2007)
21. Duran A., Serrano M., Leitges M., Flores J.M., Picard S., Brown J.P., Moscat J., and Diaz-Meco M.T. The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev. Cell 6 (2004) 303-309
22. Sanz L., Sanchez P., Lallena M.J., Diaz-Meco M.T., and Moscat J. The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. Embo. J 18 (1999) 3044-3053
23. Sanz L., Diaz-Meco M.T., Nakano H., and Moscat J. The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. Embo. J. 19 (2000) 1576-1586
24. Morissette J., Laurin N., and Brown J.P. Sequestosome 1: mutation frequencies, haplotypes, and phenotypes in familial Paget's disease of bone. J. Bone Miner. Res. 21 Suppl 2 (2006) P38-44
25. Naot D., Bava U., Matthews B., Callon K.E., Gamble G.D., Black M., Song S., Pitto R.P., Cundy T., Cornish J., and Reid I.R. Differential gene expression in cultured osteoblasts and bone marrow stromal cells from patients with Paget's disease of bone. J. Bone Miner. Res 22 (2007) 298-309