Can primary hypolactasia manifest itself after the age of 20 years? A two-decade follow-up study

Scandinavian Journal of Gastroenterology

Volumn 43, Issue 9, 2008, Pages 1082-1087

  Seppo, Leena ^a   Tuure, Tuula ^a   Korpela, Riitta ^a,b   Järvelä, Irma ^c,d   Rasinperä, Heli ^c   Sahi, Timo ^c  

^a VALIO LTD   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Hypolactasia; Lactase; Lactose; Lactose intolerance; Lactose tolerance test

Indexed keywords

LACTASE; LACTOSE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DIAGNOSTIC PROCEDURE; DNA DETERMINATION; FEMALE; FINLAND; FOLLOW UP; GASTROINTESTINAL ENDOSCOPY; GASTROINTESTINAL SYMPTOM; GENOTYPE; HUMAN; LACTASE DEFICIENCY; LACTOSE TOLERANCE; MALE; PRIORITY JOURNAL;

ADULT; AGE DISTRIBUTION; AGE OF ONSET; AGED; COHORT STUDIES; FEMALE; FINLAND; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INCIDENCE; LACTASE; LACTOSE; LACTOSE INTOLERANCE; LACTOSE TOLERANCE TEST; MALE; MIDDLE AGED; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; SEX DISTRIBUTION; TIME FACTORS;

EID: 49949087747     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.1080/00365520802095485     Document Type: Article

References (26)

1. Flatz G. Genetics of lactose digestion in humans. Adv Hum Genet 1987;16:1-77.
2. Sahi T. Genetics and epidemiology of adult-type hypolactasia. Scand J Gastroenterol 1994;Suppl 29:7-20.
3. Sahi T, Launiala K, Laitinen H. Hypolactasia in a fixed cohort of young Finnish adults. A follow-up study. Scand J Gastroenterol 1983;18:865-70.
4. Enattah NS, Sahi T, Savilahti E, Terwilliger JD, Peltonen L, Järvelä I. Identification of a variant associated with adult-type hypolactasia. Nat Genet 2002;30:233-7.
5. Kuokkanen M, Enattah NS, Oksanen A, Savilahti E, Orpana A, Järvelä I. Transcriptional regulation of the lactasephlorhizin hydrolase gene by polymorphisms associated with adult-type hypolactasia. Gut 2003;52:647-52.
6. Rasinperä H, Savilahti E, Enattah NS, Kuokkanen M, Tötterman N, Lindahl H, et al. A genetic test which can be used to diagnose adult-type hypolactasia in children. Gut 2004;53:1571-6.
7. Arola H. Diagnosis of hypolactasia and lactose malabsorption. Scand J Gastroenterol 1994;Suppl 29:26-35.
8. Sahi T. Lactose malabsorption in Finnish-speaking and Swedish-speaking populations in Finland. Scand J Gastroenterol 1974a;9:303-8.
9. Sahi T. The inheritance of selective adult-type lactose malabsorption. Scand J Gastroenterol 1974b;Suppl 9:1-74.
10. Jussila J. Diagnosis of lactose malabsorption by the lactose tolerance test with peroral ethanol administration. Scand J Gastroenterol 1969;4:361-8.
11. Teuri U, Vapaatalo H, Korpela R. Fructo-oligosaccharides and lactulose cause more symptoms in lactose maldigesters and pseudohypolactasia subjects than in control digesters. Am J Clin Nutr 1999;69:973-9.
12. Syvänen AC, Aalto-Setälä K, Harju L, Kontula K, Söderlund H. A primer-guided nucleotide incorporation assay in the genotyping of apolipoprotein E. Genomics 1990;8:684-92.
13. Sahi T, Isokoski M, Jussila J, Launiala K. Lactose malabsorption in Finnish children of school age. Acta Paediatr Scand 1972;61:11-6.
14. Lewinsky RH, Jensen TG, Moller J, Stensballe A, Olsen J, Troelsen JT. T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro. Hum Mol Genet 2005;14:3945-53.
15. Rydel JW, Chibalin AV, Zierath JR. Intracellular mechanisms underlying increases in glucose uptake in response to insulin or exercise in skeletal muscle. Acta Physiol Scand 2001;171:249-57.
16. Enattah NS, Kuokkanen M, Forsblom C, Natah S, Oksanen A, Järvelä I, et al. Correlation of intestinal disaccharidase activities with the C/T(13910 variant and age. World J Gastroenterol 2007;13:3508-12.
17. Poulter M, Hollox E, Harvey CB, Mulcare C, Peuhkuri K, Kajander K, et al. The causal element for the lactase persistence/non-persistence polymorphism is located in a 1 Mb region of linkage disequilibrium in Europeans. Ann Hum Genet 2003;67:298-311.
18. Nilsson TK, Johansson CA. A novel method for diagnosis of adult hypolactasia by genotyping of the (13910 C/T polymorphism with pyrosequencing technology. Scand J Gastroenterol 2004;39:287-90.
19. Ridefelt P, Håkensson LD. Lactose intolerance: lactose tolerance test versus genotyping. Scand J Gastroenterol 2005;40:822-6.
20. Gugatschka M, Doping H, Fahrleitner-Pammer A, Pietschmann P, Kudlacek S, Strele A, et al. Molecularly-defined lactose malabsorption, milk consumption and anthropometric differences in adult males. Q J Med 2005;98:857-63.
21. Carroccio A, Montalto G, Cavera G, Notarbatolo A. Lactose intolerance and self-reported milk intolerance: relationship with lactose maldigestion and nutrient intake. Lactase Deficiency Study Group. J Am Coll Nutr 1998;17:631-6.
22. Suarez FL, Savaiano DA, Levitt MD. A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with self-reported severe lactose intolerance. N Engl J Med 1995;333:1-4.
23. Saltzman JR, Russell RM, Golner B, Barakat S, Dallal GE, Goldin BR. A randomized trial of Lactobacillus acidophilus BG2FO4 to treat lactose intolerance. Am J Clin Nutr 1999;69:140-6.
24. Peuhkuri K, Vapaatalo H, Korpela R. Wide variations in the testing of lactose tolerance: results of a questionnaire study in Finnish health care centres. Scand J Clin Lab Invest 2000;60:291-7.
25. Gupta SK, Chong SK, Fitzgerald JF. Disaccharidase activities in children: normal values and comparison based on symptoms and histologic changes. J Pediatr Gastroenterol Nutr 1999;28:246-51.
26. Enattah N, Pekkarinen T, Välimäki MJ, Löyttyniemi E, Järvelä I. Genetically defined adult-type hypolactasia and self-reported lactose intolerance as risk factors of osteoporosis in Finnish postmenopausal women. Eur J Clin Nutr 2005;59:1105-11.