Modeling of caffeine release from crosslinked water-swellable gelatin and gelatin-maltodextrin hydrogels

Drug Delivery

Volumn 15, Issue 7, 2008, Pages 455-463

  Abbasi, A ^a,b   Eslamian, M ^b   Rousseau, D ^a  

^a RYERSON UNIVERSITY   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Controlled release; Diffusion; Gelatin; Maltodextrin; Mathematical modeling; Swelling

Indexed keywords

BLOOM 300; CAFFEINE; CROSS LINKING REAGENT; GELATIN; GENIPIN; MALTODEXTRIN; STAR DRI 1005A; UNCLASSIFIED DRUG; WATER;

ARTICLE; CHEMICAL COMPOSITION; CONTROLLED DRUG RELEASE; DIFFUSION; DRUG PENETRATION; HYDROGEL; MATHEMATICAL MODEL; PRIORITY JOURNAL; VALIDATION PROCESS;

CAFFEINE; CROSS-LINKING REAGENTS; DELAYED-ACTION PREPARATIONS; DIFFUSION; DRUG DELIVERY SYSTEMS; GELATIN; HYDROGELS; MATHEMATICAL COMPUTING; MODELS, CHEMICAL; POLYSACCHARIDES; WATER;

EID: 49949086419     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.1080/10717540802321628     Document Type: Article

References (15)

1. Crank, J. 1975a. The mathematics of diffusion. Clarendon Press, Oxford.
2. Crank, J. 1975b. Two methods for the numerical solution of moving boundary problems in diffusion and heat flow. Q. J. Mech. Appl. Math. 10:220-231.
3. Fan, L. T., and Singh, S. K. 1989. A quantitative treatment of polymer properties and applications. J. Control. Rel. 13:20-28.
4. Fujita, H. 1967. Diffusion in polymer-diluent system. Fortschrer Fortschr Hochpolymer 3:1-47.
5. Ju, R. T. C., Nixon, P. R., Patel, M. V., and Tong, D. M. 1995. Drug-release from hydrophilic matrices. 2. A mathematical-model based on the polymer dis-entanglement concentration and the diffusion layer. J. Pharm. Sci. 84:1464-1477.
6. Kim, B., Flamme, K. L., and Peppas, N. A. 2003. Dynamic swelling behavior of pH-sensitive anionic hydrogels used for protein delivery. J. Appl. Polym. Sci. 89:1606-1613.
7. Masaro, L., and Zhu, X. X. 1999. Physical models of diffusion for polymer solutions, gels and solids. Prog. Polym. Sci. 24:731-775.
8. Nishinari, K., and Doi, E. 1994. Food hydrocolloids: structure, properties, and functions. Plenum Press, New York.
9. Siepmann, J., and Peppas, N. A. 2001. Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv. Drug Del. Rev. 48:139-157.
10. Siepmann, J., Bodmeier, R., Peppas, N. A., and Kranz, H. 1999. HPMC-matrices for controlled drug delivery: a new model combining diffusion, swelling, and dissolution mechanisms and predicting the release kinetics. Pharm. Res. 6:1748-1756.
11. Sung, H. W., Huang, R. N. Huang, L. L. H., Tsai, C. C., and Chiu, C. T. 1998. Feasibility study of a natural cross-linking reagent for biological tissue fixation. J. Biomed. Mater. Res. A 42:560-567.
12. Swarbrick, J., and Boylan, J. C. 1988. Encyclopedia of pharmaceutical technology. Volume 18. Marcel Dekker Inc., New York.
13. Vrentas, J. S., and Duda, J. L. 1977. Molecular diffusion in polymer solutions. Am. Inst. Chem. Eng. J. 25:1-24.
14. Wise, D. L. 2000. Handbook of pharmaceutical controlled release technology. Marcel Dekker, Inc., New York.
15. Yao, C. H., Liu, B. S., Chang, C. J., Hsu, S. H., and Chen, Y. S. 2004. Preparation of networks of gelatin and genipin as degradable biomaterials. Mater. Chem. Phys. 83:204-208.