Analysis of the K-ras/B-raf/Erk signal cascade, p53 and CMAP as markers for tumor progression in colorectal cancer patients

Oncology Reports

Volumn 20, Issue 1, 2008, Pages 3-11

  Georgieva, Milk ^a,c   Krasteva, Maria ^b   Angelova, Elka ^a   Ralchev, Krassimir ^a   Dimitrov, Valentin ^a   Bozhimirov, Stanislav ^b   Georgieva, Elena ^b   Berger, Martin R ^c  

^a National Oncology Center Bulgaria   (Bulgaria)

^b INSTITUTE OF PHYSIOLOGY   (Bulgaria)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

B raf mutations; Colorectal cancer; Cystatin like metastasis associated protein expression; ERK activation; K ras mutations; p53 mutation

Indexed keywords

B RAF KINASE; CYSTATIN LIKE METASTASIS ASSOCIATED PROTEIN; GENE PRODUCT; K RAS PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P53; TUMOR MARKER; UNCLASSIFIED DRUG; BRAF PROTEIN, HUMAN; CST7 PROTEIN, HUMAN; CYSTATIN;

ADULT; ADVANCED CANCER; ARTICLE; CANCER CLASSIFICATION; CANCER GROWTH; CANCER MORTALITY; CANCER STAGING; CLINICAL ARTICLE; CODON; COLORECTAL CARCINOMA; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVATION; FEMALE; FRAMESHIFT MUTATION; GASTROINTESTINAL MUCOSA; GENE MUTATION; HUMAN; HUMAN TISSUE; INTRON; LIVER; LIVER METASTASIS; MALE; MISSENSE MUTATION; NONSENSE MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SIGNAL TRANSDUCTION; SINGLE STRAND CONFORMATION POLYMORPHISM; WESTERN BLOTTING; COLORECTAL TUMOR; DISEASE COURSE; GENETICS; METABOLISM; MIDDLE AGED; MUTATION; ONCOGENE RAS; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; TUMOR SUPPRESSOR GENE;

COLORECTAL NEOPLASMS; CYSTATINS; DISEASE PROGRESSION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GENES, P53; GENES, RAS; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; MIDDLE AGED; MUTATION; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS B-RAF; TUMOR MARKERS, BIOLOGICAL;

EID: 49849105979     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: 10.3892/or.20.1.3     Document Type: Article

References (26)

1. Graziano F and Cascinu S: Prognostic molecular markers for planning adjuvant chemotherapy trials in Dukes' B colorectal cancer patients: how much evidence is enough? Ann Oncol 14: 1026-1038, 2003.
2. McLeod HL, Murray GI, Mollison J, McKay J and Cassidy J: Selection of markers to predict tumour response or survival: description of a novel approach. Eur J Cancer 35: 1650-1652, 1999.
3. Jass JR, Whitehall VL and Leggett BA: Emerging concepts in colorectal neoplasia. Gastroenterology 123: 862-867, 2002.
4. Steegeng WT, van der Eb AJ and Jochensen AG: How phosphorylation regulates the activity of p53. J Mol Biol 263: 103-113, 1999.
5. Robinson MJ and Cobb MH: Mitogen-activated protein kinase pathways. Curr Opin Cell Biol 9: 180-186, 1997.
6. Malunders M and Barbacid M: Ras oncogenes: the first 30 years. Nat Rev Cancer 3: 459-465, 2003.
7. Davies H, Bignell GR, Cox C, Stephens P, Edkin S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V. Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson B, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner D, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JWC, Leung SY, Yuen ST, Weber B, Seigler HF, Darrow T, Peterson H, Marais R, Marshall CJ, Wooster R, Straton MR and Futreal PA: Mutations of the B-Raf gene in human cancer. Nature 417: 949-954, 2002.
8. Rajagopalan H, Bardelli A, Lengauer C, Kinzler KW, Vogelstein B and Velculescu VE: Tumorigenesis: RAF/RAS oncogenes and mismatch repair status. Nature 418: 934, 2002.
9. Singer G, Oldt R III, Cohen Y, Wang BG, Sidransky D, Kurman RJ and Shih I: Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma. J Natl Cancer Inst 95: 484-486, 2003.
10. Cohen Y, Goldenberg-Cohen N, Parrella P, Chowers I, Merbs SL, Peter J and Sidransky D: Lack of BRAF mutation in primary uveal melanoma. Invest Ophtalmol Vis Sci 44: 2876-2878, 2003.
11. Eliceiri BP, Klemke R, Strömblad S and Cheresh DA: Integrin xvβ 3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis. J Cell Biol 14: 1255-1263, 1998.
12. Bonni A, Brunet A, West AE, Datta SR, Takasu MA and Greenberg ME: Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286: 1358-1362, 1999.
13. Mercer K and Pritchard CA: Raf proteins and cancer: B-Raf is identified as a mutational target. Biochim Biophys Acta 1653: 25A-40A, 2003.
14. Gonzales-Aguilera J, Oliart S, Azcoita MM and Fernandez-Peralta A: Simultaneous mutations in KRAS and TP53 are indicative of poor prognosis in sporadic colorectal cancer. Am J Clin Oncol 27: 39-45, 2004.
15. Morita M, Yoshiuchi N, Arakawa H and Nishimura S: CMAP: a novel cystatin-like gene involved in liver metastasis. Cancer Res 59: 151-158, 1999.
16. Utsunomiya T, Hara Y, Kataoka A, Morita M, Arakawa H, Mori M and Nishimura S: Clin Cancer Res: 2591-2594, 2002.
17. Dieterle CP, Conzelmann M, Linnemann U and Berger M: Detection of isolated tumor cells by polymerase chain reaction-restriction fragment length polymorphism for K-ras mutations in tissue samples of 199 colorectal cancer patients. Clin Cancer: 641-650, 2004.
18. Krasteva ME, Garanina Z and Georgieva EI: Optimized polymerase chain reaction-based single-strand conformation polymorphism analysis of p53 gene applied to Bulgarian patients with invasive breast cancer. Clin Exp Med 3: 173-180, 2003.
19. Deng G, Chen L-C, Schott DR, Thor A, Bhargava V, Ljung B-M, Chew K and Smith HS: Loss of heterozygosity and p53 gene mutations in breast cancer. Cancer Res 54: 499-505, 1999. 20 Kraus M, Seelig M, Linnemann U and Berger M: The balanced induction of K-Ras codon 12 and 13 mutations in mucosa differs from their ratio in neoplastic tissues. Int J Oncol 29: 957-964, 2006.
20. Calistri D, Rengucci C, Seymour J, Lattuneddu A, Polifemo A, Monti F, Saragoni L and Amadori D: Mutation analysis of p53, K-Ras and B-Raf genes in colorectal cancer progression. J Cell Physiol 204: 484-488, 2005.
21. Fearon ER and Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 61: 759-767, 1990.
22. Graziani D, Romagnoli S, Cassani B, Alfano RM, Roncalli M and Coggi G: An Ava I polymorphism in the TP53 gene. Mol Cell Probes 13: 393-395, 1999.
23. Krasteva ME and Georgieva EI: Germline p53 single-base changes associated with Balkan endemic nephropathy. Biochem Biophys Res Commun 342: 562-567, 2006.
24. Vousden KH and Lu X: Live or let die: the cell's response to p53. Nat Rev Cancer 2: 594-604, 2002.
25. Morita M, Hara Y, Tamai Y, Arakawa H and Nishimura S: Genomic construct and mapping of the gene for CMAP (Leukostatin/Cystatin F, CST7) and identification of a proximal novel gene BSCv (C20orf3). Genomics 67: 87-91, 2000.
26. Conzelmann M, Linnemann U and Berger MR: Molecular detection of clinical colorectal cancer metastasis: how should multiple markers be put to use? Int J Colorectal Dis 20: 137-146, 2005.