Immunohistochemical evaluation of hepatic oval cell activation and differentiation toward pancreatic beta-cell phenotype in streptozotocin-induced diabetic mice

Journal of Molecular Histology

Volumn 39, Issue 4, 2008, Pages 463-468

  Vorobeychik, M ^a   Bloch, K ^a   Zemel, R ^a   Bachmetov, L ^a   Tur Kaspa, R ^a   Vardi, P ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

A6 antigen; Diabetes; Hepatic oval cells; Proinsulin

Indexed keywords

A6 ANTIGEN; ANTIGEN; PROINSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL COUNT; CELL DENSITY; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOPLASM; IMMUNOHISTOCHEMISTRY; LIVER; LIVER CELL; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; STREPTOZOCIN DIABETES;

ANIMALS; CELL DIFFERENTIATION; DIABETES MELLITUS, EXPERIMENTAL; IMMUNOHISTOCHEMISTRY; INSULIN-SECRETING CELLS; LIVER; MALE; MICE; MICE, INBRED ICR; PHENOTYPE; STREPTOZOCIN;

ANIMALIA; MUS;

EID: 49849099119     PISSN: 15672379     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10735-008-9185-y     Document Type: Article

References (18)

1. B Akhurst EJ Croager CA Farley-Roche 2001 A modified choline-deficient, ethionine-supplemented diet protocol effectively induces oval cells in mouse liver Hepatology 34 519 522 10.1053/jhep.2001.26751
2. G Andican G Burçak 2005 Oxidative damage to nuclear DNA in streptozotocin-diabetic rat liver Clin Exp Pharmacol Physiol 32 663 666 10.1111/j.0305-1870.2005.04247.x
3. TG Bird S Lorenzini S Forbes 2008 Activation of stem cells in hepatic diseases Cell Tissue Res 331 283 300 10.1007/s00441-007-0542-z
4. G Deutsch J Jung M Zheng 2001 A bipotential precursor population for pancreas and liver within the embryonic endoderm Development 128 871 881
5. C Dorrell M Grompe 2005 Liver repair by intra- and extrahepatic progenitors Stem Cell Rev 1 61 64 10.1385/SCR:1:1:061
6. N Engelhardt V Factor A Yasova 1990 Common antigens of mouse oval and biliary epithelial cells. Expression on newly formed hepatocytes Differentiation 45 29 37 10.1111/j.1432-0436.1990.tb00453.x
7. P Jelnes E Santoni-Rugiu M Rasmussen 2007 Remarkable heterogeneity displayed by oval cells in rat and mouse models of stem cell-mediated liver regeneration Hepatology 45 1462 1470 10.1002/hep.21569
8. S Kim J Shin H Kim 2007 Streptozotocin-induced diabetes can be reversed by hepatic oval cell activation through hepatic transdifferentiation and pancreatic islet regeneration Lab Invest 87 702 712 10.1038/labinvest.3700561
9. A Kofman G Morgan A Kirschenbaum 2005 Dose- and time-dependent oval cell reaction in acetaminophen-induced murine liver injury Hepatology 41 1252 1261 10.1002/hep.20696
10. H Kojima M Fujimiya K Matsumura 2004 Extrapancreatic insulin-producing cells in multiple organs in diabetes Proc Natl Acad Sci USA 101 2458 2463 10.1073/pnas.0308690100
11. H Kojima M Fujimiya T Terashima 2006 Extrapancreatic proinsulin/insulin- expressing cells in diabetes mellitus: is history repeating itself? Endocr J 53 715 722 10.1507/endocrj.KR-84
12. H Okamoto S Takasawa 2002 Recent advances in the Okamoto model: the CD38-cyclic ADP-ribose signal system and the regenerating gene protein (Reg)-Reg receptor system in beta-cells Diabetes 51 462 473 10.2337/diabetes.51.2007.S462
13. BE Petersen JP Goff JS Greenberger GK Michalopoulos 1998 Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat Hepatology 27 433 445 10.1002/hep.510270218
14. BE Petersen B Grossbard H Hatch 2003 Mouse A6-positive hepatic oval cells also express several hematopoietic stem cell markers Hepatology 37 632 640 10.1053/jhep.2003.50104
15. S Rhee Y Jeong J Choi 2005 Effects of vitamin E on phospholipase A 2 activity and oxidative damage to the liver in streptozotocin-induced diabetic rats Ann Nutr Metab 49 392 396 10.1159/000088930
16. WJ Schnedl S Ferber JH Johnson CB Newgard 1994 STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells Diabetes 43 1326 1333 10.2337/diabetes.43.11.1326
17. B Thorens 1996 Glucose transporters in the regulation of intestinal, renal and liver glucose fluxes Am J Physiol 270 G541 G553
18. L Yang S Li H Hatch 2002 In vitro trans-differentation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells Proc Natl Acad Sci USA 99 8078 8083 10.1073/pnas.122210699