CD4 deficits and disease course acceleration can be driven by a collapse of the CD8 response in rhesus macaques infected with simian immunodeficiency virus

AIDS

Volumn 22, Issue 12, 2008, Pages 1441-1452

  Marcondes, Maria Cecilia G ^a   Sopper, Sieghart ^b   Sauermann, Ulrike ^b   Burdo, Tricia H ^a   Watry, Debbie ^a   Zandonatti, Michelle ^a   Fox, Howard S ^a,c  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c NONE   (United States)

Author keywords

Acute infection; AIDS; Brain; CD4; CD8; Simian immunodeficiency virus

Indexed keywords

ANTIBODY; EPITOPE; TETRAMER;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; COLLAPSE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DISEASE COURSE; DISEASE MARKER; IN VIVO STUDY; KINETICS; LYMPHOCYTE DEPLETION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MEMORY T LYMPHOCYTE; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS INFECTION; VIRUS LOAD; ANIMAL; BRAIN; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; IMMUNOLOGY; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; MACACA; MONKEY DISEASE; VIROLOGY;

ANIMALS; BRAIN; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; DISEASE PROGRESSION; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; MACACA MULATTA; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; T-LYMPHOCYTES, CYTOTOXIC; VIRAL LOAD;

EID: 49849093757     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e3283052fb5     Document Type: Article

References (28)

1. Anzala OA, Nagelkerke NJ, BwayoJJ, Holton D, Moses S, Ngugi EN, et al. Rapid progression to disease in African sex workers with human immunodeficiency virus type 1 infection. J Infect Dis 1995; 1710:686-689.
2. Westmoreland SV, Halpern E, Lackner AA. Simian immunodeficiency virus encephalitis in rhesus macaques is associated with rapid disease progression. J Neurovirol 1998; 4:260-268.
3. Smith SM, Holland B, Russo C, Dailey PJ, Marx PA, Connor RI. Retrospective analysis of viral load and SIV antibody responses in rhesus macaques infected with pathogenic SIV: predictive value for disease progression. AIDS Res Hum Retroviruses 1999; 15:1691-1701.
4. Staprans SI, Dailey PJ, Rosenthal A, Horton C, Grant RM, Lerche N, Feinberg MB. Simian immunodeficiency virus disease course is predicted by the extent of virus replication during primary infection. J Virol 1999; 73:4829-4839.
5. Picker LJ, Hagen SI, Lum R, Reed-Inderbitzin EF, Daly LM, Syl wester AW, et al. Insufficient production and tissue delivery of CD4R memory T cells in rapidly progressive simian immunodeficiency virus infection. J Exp Med 2004; 200:1299-1314.
6. Okoye A, Meier-Schellersheim M, Brenchley JM, Hagen SI, Walker JM, Rohankhedkar M, et al. Progressive CD4R central memory T cell decline results in CD4R effector memory insufficiency and overt disease in chronic SIV infection. J Exp Med 2007; 204:2171 -2185.
7. Roberts ES, Zandonatti MA, Watry DD, Madden LJ, Henriksen SJ, Taffe MA, Fox HS. Induction of pathogenic sets of genes in macrophages and neurons in NeuroAIDS. Am J Pathol 2003; 162:2041-2057.
8. Madden LJ, Zandonatti MA, Flynn CT, Taffe MA, Marcondes MC, Schmitz JE, et al. 1CD8R cell depletion amplifies the acute retroviral syndrome. J Neurovirol 2004; 10 (Suppl 1):58-66.
9. Bissel SJ, Wang G, Trichel AM, Murphey-Corb M, Wiley CA. 1Longitudinal analysis of monocyte/macrophage infection in simian immunodeficiency virus-infected, CD8R T-cell-de-pleted macaques that develop lentiviral encephalitis. Am J Pathol 2006; 168:1553-1569.
10. Evans DT, O'Connor DH, J ing P, DzurisJL, Sidney J, da Silva J, et al. Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef. Nat Med 1999; 5:1270-1276.
11. Hirsch VM, Santra S, Goldstein S, Plishka R, Buckler-White A, Seth A, et al. Immune failure in the absence of profound CD4R T-lymphocyte depletion in simian immunodeficiency virus-infected rapid progressor macaques. J Virol 2004; 78:275-284.
12. Evans DT, Jing P, Allen TM, O'Connor DH, Horton H, Venham JE, et al Definition of five new simian immunodeficiency virus cytotoxic T-lymphocyte epitopes and their restricting major histocompatibility complex class I molecules: evidence for an influence on disease progression. J Virol 2000; 74:7400-7410.
13. Koup RA, Safrit JT, Cao Y, Andrews CA, McLeod G, Borkowsky W, et al. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol 1994; 68:4650-4655.
14. Pantaleo G, Soudeyns H, Demarest JF, Vaccarezza M, Graziosi C, Paolucci S, et al. Evidence for rapid disappearance of initially expanded HIV-specific CD8R Tcell clones during primary HIV infection. Proc Natl Acad Sci U S A 1997; 94:9848-9853.
15. Hay CM, Ruhl DJ, Basgoz NO, Wilson CC, Billingsley JM, DePasquale MP, et al. Lack of viral escape and defective in vivo activation of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes in rapidly progressive infection. J Virol 1999; 73:5509-5519.
16. Islam SA, Hay CM, Hartman KE, He S, Shea AK, Trocha AK, et al. Persistence of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte clones in a subject with rapid disease progression. J Virol 2001; 75:4907-4911.
17. Allen TM, Sidney J, del Guercio MF, Glickman RL, Lensmeyer GL, Wiebe DA, et al. Characterization of the peptide binding motif of a rhesus MHC class I molecule (Mamu-AM01) that binds an immunodominant CTL epitope from simian immunodeficiency virus. J Immunol 1998; 160:6062-6071.
18. Allen TM, O'Connor DH, Jing P, DzurisJL, Mothe BR, Vogel TU, et al. Tat-specific cytotoxic T lymphocytes select for SI V escape variants during resolution of primary viraemia. Nature 2000; 407:386-390.
19. Kuroda MJ, SchmitzJE, Barouch DH, Craiu A, Allen TM, Sette A, et al. Analysis of Gag-specific cytotoxic T lymphocytes in simian immunodeficiency virus-infected rhesus monkeys by cell staining with a tetrameric major histocompatibility complex class I-peptide complex. J Exp Med 998; 187:1373-1381.
20. Newberg MH, McEvers KJ, Gorgone DA, Lifton MA, Baumeister SH, Veazey RS, et al. Immunodomination in the evolution of dominant epitope-specific CD8R T lymphocyte responses in simian immunodeficiency virus-infected rhesus monkeys. J Immunol 2006; 176:319-328.
21. Marcondes MC, Burdo TH, Sopper S, Huitron-Resendiz S, Lanigan C, Watry D, et al. Enrichment and persistence of virus-specific CTL in the brain of simian immunodeficiency virus-infected monkeys is associated with a unique cytokine environment. J Immunol 2007; 178:5812-5819.
22. Watry D, Lane TE, Streb M, Fox HS. Transfer of neuropatho-genic simian immunodeficiency virus 0with naturally infected microglia. Am J Pathol 1995; 146:914-923.
23. Marcondes MC, Burudi EM, Huitron-Resendiz S, Sanchez-Ala-vez M, Watry D, Zandonatti M, et al. Highly activated CD8(R) T cells in the brain correlate with early central nervous system dysfunction in simian immunodeficiency virus infection. J Immunol 2001; 167:5429-5438.
24. Sauermann U, Stahl-Hennig C, Stolte N, Muhl T, Krawczak M, Spring M, et al. Homozygosity for a conserved Mhc class II DQ-DRB haplotype is associated with rapid disease progression in simian immunodeficiency virus-infected macaques: results from a prospective study. J Infect Dis 2000; 182:716-724.
25. Sopper S, Sauer U, Muller JG, Stahl-Hennig C, ter Meulen V. Early activation and proliferation of T cells in simian immunodeficiency virus-infected rhesus monkeys. AIDS Res Hum Retroviruses 2000; 16:689-697.
26. Garber DA, Silvestri G, Barry AP, Fedanov A, Kozyr N, McClure H, et al. Blockade of T cell costimulation reveals interrelated actions of CD4R and CD8R T cells in control of SIV replication. J Clin Invest 2004; 113:836-845.
27. Shedlock DJ, Shen H. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 2003; 300:337-339.
28. Regoes RR, Antia R, Garber DA, Silvestri G, Feinberg MB, Staprans SI. Roles of target cells and virus-specific cellular immunity in primary simian immunodeficiency virus infection. J Virol 2004; 78:4866-4875.