Induction of characteristic hepatocyte proliferative lesion with dietary exposure of Wistar Hannover rats to tocotrienol for 1 year

Toxicology

Volumn 250, Issue 2-3, 2008, Pages 143-150

  Tasaki, Masako ^a   Umemura, Takashi ^a   Inoue, Tomoki ^a   Okamura, Toshiya ^a   Kuroiwa, Yuichi ^a   Ishii, Yuji ^a   Maeda, Machiko ^a   Hirose, Masao ^b   Nishikawa, Akiyoshi ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b Food Safety Commission of Japan   (Japan)

Author keywords

Chronic exposure; GST P; Hepatocyte proliferative lesion; Tocotrienol; Wistar Hannover rat

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA TOCOTRIENOL; CYCLINE; GLUTATHIONE TRANSFERASE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING; CAUSE OF DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG MEGADOSE; EXPOSURE; FEMALE; HEPATITIS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIVER CELL DAMAGE; LIVER CYST; LIVER NODULE; MALE; NONHUMAN; ORGAN INJURY; PRIORITY JOURNAL; RAT; SPONGIOSIS HEPATIS; STATISTICAL SIGNIFICANCE; WEIGHT REDUCTION; WISTAR HANNOVER RAT;

ANIMALS; ANTIOXIDANTS; BLOOD CELL COUNT; BLOOD CHEMICAL ANALYSIS; BODY WEIGHT; CELL PROLIFERATION; DIET; EATING; FEMALE; GLUTATHIONE TRANSFERASE; HEPATOCYTES; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS, EXPERIMENTAL; MALE; ORGAN SIZE; RATS; RATS, WISTAR; TOCOTRIENOLS;

ANIMALIA; RATTUS;

EID: 49849083819     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2008.07.003     Document Type: Article

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