Contrasting drug resistance phenotypes resulting from cytomegalovirus DNA polymerase mutations at the same exonuclease locus

Journal of Clinical Virology

Volumn 43, Issue 1, 2008, Pages 107-109

  Chou, Sunwen ^a,b   Marousek, Gail ^b   Li, Shaobing ^c   Weinberg, Adriana ^c,d  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b PORTLAND VA MEDICAL CENTER   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

Antiviral drug resistance; Cytomegalovirus; Viral DNA polymerase mutations

Indexed keywords

ANTIVIRUS AGENT; CIDOFOVIR; DNA POLYMERASE; EXONUCLEASE; GANCICLOVIR;

ANTIVIRAL THERAPY; ARTICLE; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; GENE MUTATION; HOMOLOGOUS RECOMBINATION; IC 50; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REPORTER GENE; VIRUS STRAIN;

ANTIVIRAL AGENTS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; CYTOSINE; DNA-DIRECTED DNA POLYMERASE; DRUG RESISTANCE, VIRAL; EXODEOXYRIBONUCLEASES; FOSCARNET; GANCICLOVIR; HUMANS; MUTATION; PHENOTYPE; PHOSPHONIC ACIDS; PROTEIN STRUCTURE, TERTIARY; VIRAL PROTEINS;

EID: 49749146368     PISSN: 13866532     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcv.2008.04.005     Document Type: Article

References (10)

1. Gilbert C., and Boivin G. Human cytomegalovirus resistance to antiviral drugs. Antimicrob Agents Chemother 49 (2005) 873-883
2. Cihlar T., Fuller M.D., and Cherrington J.M. Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. J Virol 72 (1998) 5927-5936
3. Chou S., Lurain N.S., Thompson K.D., Miner R.C., and Drew W.L. Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus. J Infect Dis 188 (2003) 32-39
4. Chou S., Marousek G.I., Van Wechel L.C., Li S., and Weinberg A. Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens. Antimicrob Agents Chemother 51 (2007) 4160-4162
5. Chou S., Van Wechel L.C., Lichy H.M., and Marousek G.I. Phenotyping of cytomegalovirus drug resistance mutations by using recombinant viruses incorporating a reporter gene. Antimicrob Agents Chemother 49 (2005) 2710-2715
6. Eckle T., Prix L., Jahn G., Klingebiel T., Handgretinger R., Selle B., et al. Drug-resistant human cytomegalovirus infection in children after allogeneic stem cell transplantation may have different clinical outcomes. Blood 96 (2000) 3286-3289
7. Erice A., Gil-Roda C., Perez J.L., Balfour Jr. H.H., Sannerud K.J., Hanson M.N., et al. Antiviral susceptibilities and analysis of UL97 and DNA polymerase sequences of clinical cytomegalovirus isolates from immunocompromised patients. J Infect Dis 175 (1997) 1087-1092
8. Reddy A.J., Zaas A.K., Hanson K.E., and Palmer S.M. A single-center experience with ganciclovir-resistant cytomegalovirus in lung transplant recipients: treatment and outcome. J Heart Lung Transplant 26 (2007) 1286-1292
9. Scott G.M., Weinberg A., Rawlinson W.D., and Chou S. Multidrug resistance conferred by novel DNA polymerase mutations in human cytomegalovirus isolates. Antimicrob Agents Chemother 51 (2007) 89-94
10. Liu S., Knafels J.D., Chang J.S., Waszak G.A., Baldwin E.T., Deibel Jr. M.R., et al. Crystal structure of the herpes simplex virus 1 DNA polymerase. J Biol Chem 281 (2006) 18193-18200