Toxicity and antitumor activity of the vitamin D analogs PRI-1906 and PRI-1907 in combined treatment with cyclophosphamide in a mouse mammary cancer model

Cancer Chemotherapy and Pharmacology

Volumn 62, Issue 5, 2008, Pages 787-797

  Wietrzyk, Joanna ^a   Nevozhay, Dmitry ^a,b   Milczarek, Magdalena ^a   Filip, Beata ^a   Kutner, Andrzej ^c  

^a INSTITUTE OF IMMUNOLOGY AND EXPERIMENTAL THERAPY   (Poland)

^b Kopvillem Institute of Medical Physics   (Russian Federation)

^c INDUSTRIAL CHEMISTRY RESEARCH INSTITUTE   (Poland)

Author keywords

(1S,24R) 1,24 dihydroxyvitamin D3; Analogs; Antitumor; Calcitriol; Chemotherapy; Steroid

Indexed keywords

24 DEHYDRO 24A HOMO 1,25 DIHYDROXYERGOCALCIFEROL; 24 DEHYDRO 24A,26,27 TRIHOMO 1,25 DIHYDROXYERGOCALCIFEROL; CALCITRIOL; CALCITRIOL DERIVATIVE; CALCIUM; CYCLOPHOSPHAMIDE; PRI 1906; PRI 1907; PRI 2191; PROTEIN P27; TACALCITOL; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CALCIUM BLOOD LEVEL; CELL CYCLE; CELL CYCLE ARREST; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; FEMALE; LD 50; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE DRUG DOSE; WEIGHT CHANGE;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BODY WEIGHT; CALCITRIOL; CALCIUM; CELL CYCLE; CYCLOPHOSPHAMIDE; DIHYDROXYCHOLECALCIFEROLS; ERGOCALCIFEROLS; FEMALE; LETHAL DOSE 50; MALE; MAMMARY NEOPLASMS, ANIMAL; MICE; MICE, INBRED C3H; MICE, INBRED DBA; VITAMINS;

EID: 49749135218     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-007-0666-6     Document Type: Article

References (55)

1. A Opolski J Wietrzyk A Chrobak E Marcinkowska E Wojdat A Kutner C Radzikowski 1999 Antiproliferative activity in vitro of side-chain analogues of calcitriol against various human normal and cancer cell lines Anticancer Res 19 5217 5222
2. H Asou M Koike E Elstner M Cambell J Le MR Uskokovic N Kamada HP Koeffler 1998 19-nor vitamin-D analogs: a new class of potent inhibitors of proliferation and inducers of differentiation of human myeloid leukemia cell lines Blood 92 2441 2449
3. J Li RA Finch AC Sartorelli 1999 Role of vitamin D3 receptor in the synergistic differentiation of WEHI-3B leukemia cells by vitamin D3 and retinoic acid Exp Cell Res 249 279 290
4. 3, a potent angiogenesis inhibitor, on rat mammary tumors induced by 7,12-dimethylbenz[a] anthracene Anticancer Drugs 2 475 480
5. 3 and their combination inhibit angiogenesis induced by non-HPV-harboring tumor cell lines. RAR alpha mediates the antiangiogenic effect of retinoids Cancer Lett 89 117 124
6. AW Norman MT Mizwicki WH Okamura 2003 Ligand structure-function relationships in the vitamin D endocrine system from the perspective of drug development (including cancer treatment) Recent Results Cancer Res 164 55 82
7. H Reichel HP Koeffler AW Norman 1989 The role of the vitamin D endocrine system in health and disease N Engl J Med 320 980 991
8. A Opolski J Wietrzyk A Siwinska E Marcinkowska A Chrobak C Radzikowski A Kutner 2000 Biological activity in vitro of side-chain modified analogues of calcitriol Curr Pharm Des 6 755 765
9. 3 J Steroid Biochem Mol Biol 67 71 78
10. 3 activate three MAPK pathways and upregulate pRb expression in differentiating HL60 cells Cell Cycle 1 410 415
11. E Marcinkowska A Kutner 2002 Side-chain modified vitamin D analogs require activation of both PI 3-K and erk1,2 signal transduction pathways to induce differentiation of human promyelocytic leukemia cells Acta Biochim Pol 49 393 406
12. J Elias B Marian C Edling B Lachmann CR Noe SH Rolf I Schuster 2003 Induction of apoptosis by vitamin D metabolites and analogs in a glioma cell line Recent Results Cancer Res 164 319 332
13. MT Shokravi DM Marcus J Alroy K Egan MA Saornil DM Albert 1995 Vitamin D inhibits angiogenesis in transgenic murine retinoblastoma Invest Ophthalmol Vis Sci 36 83 87
14. 3 diminishes tumor-induced myelopoiesis and associated immunosuppression, and reduces tumor metastasis and recurrence Cancer Immunol Immunother 41 37 45
15. 2 metabolite, inhibits growth of breast cancer cells and tumors Anticancer Res 25 235 241
16. SA Lamprecht M Lipkin 2003 Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms Nat Rev Cancer 3 601 614
17. 3 receptor as a target for breast cancer prevention J Nutr 133 2425S 2433S
18. 5, a synthetic analog of vitamin D Mutat Res 523-524 253 264
19. AV Krishnan DM Peehl D Feldman 2003 The role of vitamin D in prostate cancer Recent Results Cancer Res 164 205 221
20. DC Smith CS Johnson CC Freeman J Muindi JW Wilson DL Trump 1999 A Phase I trial of calcitriol (1,25-dihydroxycholecalciferol) in patients with advanced malignancy Clin Cancer Res 5 1339 1345
21. DM Peehl AV Krishnan D Feldman 2003 Pathways mediating the growth-inhibitory actions of vitamin D in prostate cancer J Nutr 133 2461S 2469S
22. K Dalhoff J Dancey L Astrup T Skovsgaard KJ Hamberg FJ Lofts O Rosmorduc S Erlinger HJ Bach WP Steward T Skov F Burcharth TR Evans 2003 A phase II study of the vitamin D analogue Seocalcitol in patients with inoperable hepatocellular carcinoma Br J Cancer 89 252 257
23. JR Muindi Y Peng DM Potter PA Hershberger JS Tauch MJ Capozzoli MJ Egorin CS Johnson DL Trump 2002 Pharmacokinetics of high-dose oral calcitriol: results from a phase 1 trial of calcitriol and paclitaxel Clin Pharmacol Ther 72 648 659
24. TM Beer KM Hough M Garzotto BA Lowe WD Henner 2001 Weekly high-dose calcitriol and docetaxel in advanced prostate cancer Semin Oncol 28 49 55
25. LC Lowe M Guy JL Mansi C Peckitt J Bliss RG Wilson KW Colston 2005 Plasma 25-hydroxy vitamin D concentrations, vitamin D receptor genotype and breast cancer risk in a UK Caucasian population Eur J Cancer 41 1164 1169
26. 3 receptor promoter in breast cancer cells is mediated through Sp1 sites Mol Cell Endocrinol 230 59 68
27. 3 and platinum drugs on the growth of MCF-7 cells Cancer Res 51 2848 2853
28. 3 enhances the susceptibility of breast cancer cells to doxorubicin-induced oxidative damage Cancer Res 59 862 867
29. A Siwinska A Opolski A Chrobak J Wietrzyk E Wojdat A Kutner W Szelejewski C Radzikowski 2001 Potentiation of the antiproliferative effect in vitro of doxorubicin, cisplatin and genistein by new analogues of vitamin D Anticancer Res 21 1925 1929
30. A Chrobak C Radzikowski A Opolski 2005 Side-chain-modified analogs of calcitriol cause resistance of human HL-60 promyelocytic leukemia cells to drug-induced apoptosis Steroids 70 19 27
31. 3, inhibits the growth of human breast cancer in vitro and in vivo without causing hypercalcemia Endocrinology 129 832 837
32. J Abe-Hashimoto T Kikuchi T Matsumoto Y Nishii E Ogata K Ikeda 1993 Antitumor effect of 22-oxa-calcitriol, a noncalcemic analogue of calcitriol, in athymic mice implanted with human breast carcinoma and its synergism with tamoxifen Cancer Res 53 2534 2537
33. TM Beer D Lemmon BA Lowe WD Henner 2003 High-dose weekly oral calcitriol in patients with a rising PSA after prostatectomy or radiation for prostate carcinoma Cancer 97 1217 1224
34. 3. 587-589
35. R Bouillon WH Okamura AW Norman 1995 Structure-function relationships in the vitamin D endocrine system Endocr Rev 16 200 257
36. 3 (PRI-2191) Steroids 69 629 635
37. 2. (24E)-(1S)-24- Dehydro-24a-homo-1,25-dihydroxyergocalciferol and congeners Steroids 67 789 798
38. 3 compounds in combination with cytostatics Anticancer Res 25 2235 2240
39. GJ Peters CL van der Wilt CJ van Moorsel JR Kroep AM Bergman SP Ackland 2000 Basis for effective combination cancer chemotherapy with antimetabolites Pharmacol Ther 87 227 253
40. J Rak H Kusnierczyk L Strzadala S Klosiewicz C Radzikowski 1989 Transplantable mouse mammary adenocarcinoma 16/c as a model in experimental cancer therapy. III. Sensitivity to antitumor drugs Arch Immunol Ther Exp (Warsz ) 37 389 397
41. 3 inhibit the growth of human breast cancer cells in vitro and in vivo Cancer Res 60 2673 2679
42. 2: antitumor activity against leukemia, myeloma, and colon cancer cells J Natl Cancer Inst 95 896 905
43. 3 analogue seocalcitol (EB 1089): chemical synthesis, biological evaluation and potency enhancement of the anticancer drug adriamycin Bioorg Med Chem 9 2365 2371
44. 3 analog with potent ability to induce HL-60 cell differentiation without modulating calcium metabolism Blood 78 75 82
45. 3 analogs and their 24-oxo metabolites equally inhibit clonal proliferation of a variety of cancer cells but have differing molecular effects J Cell Biochem 66 413 425
46. 3 in athymic mice with Y-79 human retinoblastoma tumors Arch Ophthalmol 117 365 370
47. PA Hershberger WD Yu RA Modzelewski RM Rueger CS Johnson DL Trump 2001 Calcitriol (1,25-dihydroxycholecalciferol) enhances paclitaxel antitumor activity in vitro and in vivo and accelerates paclitaxel-induced apoptosis Clin Cancer Res 7 1043 1051
48. 3 and platinum drugs act synergistically to inhibit the growth of prostate cancer cell lines Clin Cancer Res 5 695 703
49. M Mazurkiewicz A Opolski J Wietrzyk C Radzikowski Z Kleinrok 1999 GABA level and GAD activity in human and mouse normal and neoplastic mammary gland J Exp Clin Cancer Res 18 247 253
50. 3 analogues in breast cancer cells Cancer Res 56 2789 2794
51. 3 J Bone Miner Res 6 1021 1027
52. 3 Proc Natl Acad Sci USA 87 9751 9755
53. 3 receptor Nucleic Acids Res 34 543 554
54. Kip1 by the VDR/Sp1 complex J Cell Biochem 98 1450 1456
55. 3 Oncogene 23 4856 4861