Analysis of gene and protein expression of cytochrome P450 and stress-associated molecules in rat liver after spaceflight

Pathology International

Volumn 58, Issue 9, 2008, Pages 589-595

  Baba, Taisuke ^a   Nishimura, Masuhiro ^b   Kuwahara, Yoshikazu ^a   Ueda, Nobuhiko ^b   Naitoh, Shinsaku ^b   Kume, Makoto ^c   Yamamoto, Yuzo ^c   Fujita, Jun ^d   Funae, Yoshihiko ^e   Fukumoto, Manabu ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^c AKITA UNIVERSITY   (Japan)

^d KYOTO UNIVERSITY   (Japan)

^e OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cold stress; Cytochrome P450; Heat shock protein; Rat liver; Spaceflight

Indexed keywords

COLD INDUCIBLE RNA BINDING PROTEIN; CYTOCHROME P450; CYTOCHROME P450 4A1; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; PROTEIN P53; RNA BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CIRP GENE; COLD STRESS; CONTROLLED STUDY; CYP4A1 GENE; ENZYME SPECIFICITY; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INCIDENCE; LIVER DISEASE; LIVER METABOLISM; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; SPACE FLIGHT; TUMOR SUPPRESSOR GENE;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; RNA-BINDING PROTEINS; SPACE FLIGHT; TUMOR SUPPRESSOR PROTEIN P53;

EID: 49749110462     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2008.02275.x     Document Type: Article

References (33)

1. Merrill AH Jr., Wang M, Hoel E et al. Altered carbohydrate, lipid, and xenobiotic metabolism by liver from rats flown on Cosmos 1887. FASEB J 1990 4 : 95 100.
2. Rabot S, Szylit O, Nugon-Baudon L et al. Variations in digestive physiology of rats after short duration flights aboard the US space shuttle. Dig Dis Sci 2000 45 : 1687 95.
3. Abraham S, Lin CY, Klein HP, Volkmann C, Tigranyan RA, Vetrova EG. Studies of specific hepatic enzymes involved in the conversion of carbohydrates to lipids in rats exposed to prolonged spaceflight aboard Cosmos 1129. Physiologist 1980 23 : S55 8.
4. Ohnishi T, Takahashi A, Wang X, Ohnishi K, Ohira Y, Nagaoka S. Accumulation of a tumor suppressor p53 protein in rat muscle during a space flight. Mutat Res 1999 430 : 271 4.
5. Houry WA. Chaperone-assisted protein folding in the cell cytoplasm. Curr Protein Pept Sci 2001 2 : 227 44.
6. Zhao R, Houry WA. Molecular interaction network of the Hsp90 chaperone system. Adv Exp Med Biol 2007 594 : 27 36.
7. Fujita J. Cold shock response in mammalian cells. J Mol Microbiol Biotechnol 1999 1 : 243 55.
8. Badhwar GD. Radiation dose rates in Space Shuttle as a function of atmospheric density. Radiat Meas 1999 30 : 401 14.
9. Furukawa M, Nishimura M, Ogino D et al. Cytochrome p450 gene expression levels in peripheral blood mononuclear cells in comparison with the liver. Cancer Sci 2004 95 : 520 29.
10. Imaoka S, Yamada T, Hiroi T et al. Multiple forms of human P450 expressed in Saccharomyces cerevisiae. Systematic characterization and comparison with those of the rat. Biochem Pharmacol 1996 51 : 1041 50.
11. Itoh H, Tashima Y. A novel testis-specific 105-kDa protein related to the 90-kDa heat-shock protein. Eur J Biochem 1990 193 : 429 35.
12. Morey-Holton ER, Halloran BP, Garetto LP, Doty SB. Animal housing influences the response of bone to spaceflight in juvenile rats. J Appl Physiol 2000 88 : 1303 9.
13. Dhir RN, Shapiro BH. Interpulse growth hormone secretion in the episodic plasma profile causes the sex reversal of cytochrome P450s in senescent male rats. Proc Natl Acad Sci USA 2003 100 : 15 224 8.
14. Macho L, Kvetnansky R, Nemeth S et al. Effects of space flight on endocrine system function in experimental animals. Environ Med 1996 40 : 95 111.
15. Legraverend C, Mode A, Westin S et al. Transcriptional regulation of rat P-450 2C gene subfamily members by the sexually dimorphic pattern of growth hormone secretion. Mol Endocrinol 1992 6 : 259 66.
16. Macho L, Kvetnansky R, Fickova M, Popova IA, Grigoriev A. Effects of exposure to space flight on endocrine regulations in experimental animals. Endocr Regul 2001 35 : 101 14.
17. Abraham S, Lin CY, Volkmann CM, Klein HP. Biochemical changes in rat liver after 18.5 days of spaceflight. Proc Soc Exp Biol Med 1983 172 : 334 9.
18. Paranjpe S, Bowen WC, Bell AW, Nejak-Bowen K, Luo JH, Michalopoulos GK. Cell cycle effects resulting from inhibition of hepatocyte growth factor and its receptor c-Met in regenerating rat livers by RNA interference. Hepatology 2007 45 : 1471 77.
19. Grindeland RE. Cosmos 1887: Science overview. FASEB J 1990 4 : 10 15.
20. Abraham S, Klein HP, Lin CY, Volkmann C. The effects of space flight on some rat liver enzymes regulating carbohydrate and lipid metabolism. Adv Space Res 1981 1 : 199 217.
21. Su GM, Fiala-Beer E, Weber J, Jahn D, Robertson GR, Murray M. Pretranslational upregulation of microsomal CYP4A in rat liver by intake of a high-sucrose, lipid-devoid diet containing orotic acid. Biochem Pharmacol 2005 69 : 709 17.
22. Dugyala RR, Claggett TW, Kimmel GL, Kimmel CA. HSP90alpha, HSP90beta, and p53 expression following in vitro hyperthermia exposure in gestation day 10 rat embryos. Toxicol Sci 2002 69 : 183 90.
23. Muller L, Schaupp A, Walerych D, Wegele H, Buchner J. Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures. J Biol Chem 2004 279 : 48 846 54.
24. Nishiyama H, Higashitsuji H, Yokoi H et al. Cloning and characterization of human CIRP (cold-inducible RNA-binding protein) cDNA and chromosomal assignment of the gene. Gene 1997 204 : 115 20.
25. Ohnishi T, Wang X, Ohnishi K, Takahashi A. p53-dependent induction of WAF1 by cold shock in human glioblastoma cells. Oncogene 1998 16 : 1507 11.
26. Sonna LA, Fujita J, Gaffin SL, Lilly CM. Effects of heat and cold stress on mammalian gene expression. J Appl Physiol 2002 92 : 1725 42.
27. Kornmann B, Schaad O, Bujard H, Takahashi JS, Schibler U. System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biol 2007 5 : e34.
28. Robinson EL, Fuller CA. Gravity and thermoregulation: Metabolic changes and circadian rhythms. Pflugers Arch 2000 441 : R32-8.
29. Fitts RH, Riley DR, Widrick JJ. Functional and structural adaptations of skeletal muscle to microgravity. J Exp Biol 2001 204 : 3201 8.
30. Gasbarrini A, Esposti SD, Di Campli C et al. Effect of ischemia-reperfusion on heat shock protein 70 and 90 gene expression in rat liver: Relation to nutritional status. Dig Dis Sci 1998 43 : 2601 5.
31. Gromova OA, Grishanova AY, Perepechaeva ML, Kolosova NG, Kolpakov AR. Effect of long-term cold exposure on activities of cytochrome P450-containing monooxygenases and glutathione S-transferase in rat liver microsomes. Bull Exp Biol Med 2004 138 : 237 9.
32. King FW, Wawrzynow A, Hohfeld J, Zylicz M. Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53. EMBO J 2001 20 : 6297 305.
33. Walerych D, Kudla G, Gutkowska M et al. Hsp90 chaperones wild-type p53 tumor suppressor protein. J Biol Chem 2004 279 : 48 836 45.