Identification of neurocircuitry controlling cardiovascular function in humans using functional neurosurgery: Implications for exercise control

Experimental Physiology

Volumn 93, Issue 9, 2008, Pages 1022-1028

  Green, Alexander L ^a   Paterson, David J ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTERIAL PRESSURE; BLOOD PRESSURE; BLOOD PRESSURE REGULATION; BRAIN DEPTH STIMULATION; BRAIN REGION; BRAIN STEM; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR RESPONSE; CARDIOVASCULAR SYSTEM; CHOLINERGIC ACTIVITY; ELECTRIC POTENTIAL; ELECTROSTIMULATION; EXERCISE; FEEDBACK SYSTEM; HUMAN; NEUROMODULATION; NEUROSURGERY; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRESSORECEPTOR REFLEX; REVIEW; SYMPATHETIC TONE;

EID: 49749091165     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2007.039461     Document Type: Review

References (42)

1. Abrahams VC, Hilton SM & Zbrozyna A (1960). Active muscle vasodilatation produced by stimulation of the brain stem: its significance in the defence reaction. J Physiol 154, 491 513.
2. Bandler R, Keay KA, Floyd N & Price J (2000). Central circuits mediating patterned autonomic activity during active vs. passive emotional coping. Brain Res Bull 53, 95 104.
3. Berntson GG, Sarter M & Cacioppo JT (1998). Anxiety and cardiovascular reactivity: the basal forebrain cholinergic link. Behav Brain Res 94, 225 248.
4. Burns SM & Wyss JM (1985). The involvement of the anterior cingulate cortex in blood pressure control. Brain Res 340, 71 77.
5. Carrive P & Bandler R (1991a). Control of extracranial and hindlimb blood flow by the midbrain periaqueductal grey of the cat. Exp Brain Res 84, 599 606.
6. Carrive P & Bandler R (1991b). Viscerotopic organization of neurons subserving hypotensive reactions within the midbrain periaqueductal grey: a correlative functional and anatomical study. Brain Res 541, 206 215.
7. Ciriello J & Calaresu FR (1981). Projections from buffer nerves to the nucleus of the solitary tract: an anatomical and electrophysiological study in the cat. J Auton Nerv Syst 3, 299 310.
8. Coote JH (2007). Landmarks in understanding the central nervous control of the cardiovascular system. Exp Physiol 92, 3 18.
9. Eldridge FL, Millhorn DE & Waldrop TG (1981). Exercise hyperpnea and locomotion: parallel activation from the hypothalamus. Science 211, 844 846.
10. Green AL, Wang S, Owen SLF, Xie K, Liu X, Paterson DJ, Stein JF, Bain PG & Aziz TZ (2005). Deep brain stimulation can regulate arterial blood pressure in awake humans. Neuroreport 16, 1741 1745.
11. Green AL, Wang S, Purvis S, Owen SL, Bain PG, Stein JF, Guz A, Aziz TZ & Paterson DJ (2007). Identifying cardiorespiratory neurocircuitry involved in central command during exercise in humans. J Physiol 578, 605 612.
12. Guertzenstein PG & Silver A (1974). Fall in blood pressure produced from discrete regions of the ventral surface of the medulla by glycine and lesions. J Physiol 242, 489 503.
13. Guyenet P (2006). The sympathetic control of blood pressure. Nat Rev Neurosci 7, 335 346.
14. Guyenet PG, Stornetta RL & Bayliss DA (2008). Retrotrapezoid nucleus and central chemoreception. J Physiol 586, 2043 2048.
15. Haselton JR & Guyenet PG (1989). Central respiratory modulation of medullary sympathoexcitatory neurons in rat. Am J Physiol Regul Integr Comp Physiol 256, R739 R750.
16. Hilton SM & Spyer KM (1980). Central nervous regulation of vascular resistance. Annu Rev Physiol 42, 399 441.
17. Hilton SM & Zbrozyna AW (1963). Amygdaloid region for defence reactions and its efferent pathway to the brain stem. J Physiol 165, 160 173.
18. Hunsperger RW (1956). Affective reaction from electric stimulation of brain stem in cats [in German]. Helv Physiol Pharmacol Acta 14, 70 92.
19. Iwamoto GA, Wappel SM, Fox GM, Buetow KA & Waldrop TG (1996). Identification of diencephalic and brainstem cardiorespiratory areas activated during exercise. Brain Res 726, 109 122.
20. Johnson PL, Lightman SL & Lowry CA (2004). A functional subset of serotonergic neurons in the rat ventrolateral periaqueductal gray implicated in the inhibition of sympathoexcitation and panic. Ann N Y Acad Sci 1018, 58 64.
21. Jordan D & Spyer KM (1977). Studies on the termination of sinus nerve afferents. Pflugers Arch 369, 65 73.
22. Kabat H, Magoun HW & Ranson SW (1935). Electrical stimulation of points in the forebrain and midbrain. The resultant alteration in blood pressure. Arch Neurol Psych 34, 931 955.
23. King AB, Menon RS, Hachinski V & Cechetto DF (1999). Human forebrain activation by visceral stimuli. J Comp Neurol 413, 572 582.
24. Kramer JM, Jarboe MO & Waldrop TG (1996). Periaqueductal gray neuronal responses to hindlimb muscle contraction in the cat. Soc Neurosci Abstr 22, 89.
25. Krogh A & Lindhard J (1913). The regulation of respiration and circulation during the initial stages of muscular work. J Physiol 47, 112 136.
26. Loewi O (1921). Uber humorale Ubertragbarkeit der Herznervenwirkung. Pflugers Arch 189, 239 242.
27. Loewy AD & Spyer KM (1990). In Central regulation of Autonomic Functions. Oxford University Press, New York.
28. McIntyre CC, Savasta M, Walter BL & Vitek JL (2004). How does deep brain stimulation work? Present understanding and future questions. J Clin Neurophysiol 21, 40 50.
29. Mitchell JH (1990). J.B. Wolffe memorial lecture. Neural control of the circulation during exercise. Med Sci Sports Exerc 22, 141 154.
30. Montastruc JL, Rascol O & Senard JM (1996). The discovery of vasomotor nerves. Clin Auton Res 6, 183 187.
31. Morgan WP, Hirta K, Weitz GA & Balke B (1976). Hypnotic perturbation of perceived exertion: ventilatory consequences. Am J Clin Hypn 18, 182 190.
32. Nashold BS Jr., Wilson WP & Slaughter DG (1969). Sensations evoked by stimulation in the midbrain of man. J Neurosurg 30, 14 24.
33. Nowak M, Holm S, Biering-Sørensen F, Secher NH & Friberg L (2005). "Central command" and insular activation during attempted foot lifting in paraplegic humans. Hum Brain Mapp 25, 259 265.
34. Risold PY, Thompson RH & Swanson LW (1997). The structural organization of connections between hypothalamus and cerebral cortex. Brain Res Brain Res Rev 24, 197 254.
35. Spyer KM & Gilbey MP (1988). Cardiorespiratory interactions in heart-rate control. Ann N Y Acad Sci 533, 350 357.
36. Thornton JM, Aziz T, Schlugman D & Paterson DJ (2002). Electrical stimulation of the midbrain increases heart rate and arterial blood pressure in awake humans. J Physiol 539, 615 621.
37. Thornton JM, Guz A, Murphy K, Griffith AR, Pedersen DL, Kardos A, Leff A, Adams L, Casadei B & Paterson DJ (2001). Identification of higher brain centres that may encode the cardiorespiratory response to exercise in humans. J Physiol 533, 823 836.
38. Verberne AJ & Owens NC (1998). Cortical modulation of the cardiovascular system. Prog Neurobiol 54, 149 168.
39. Williams CA (1996). Neuropeptide Y-like substances are released from the rostral brainstem of cats during the muscle pressor response. J Physiol 495, 267 277.
40. Williamson JW, Fadel PJ & Mitchell JH (2006). New insights into central cardiovascular control during exercise in humans: a central command update. Exp Physiol 91, 51 58.
41. Williamson JW, McColl R, Mathews D, Ginsburg M & Mitchell JH (1999). Activation of the insular cortex is affected by the intensity of exercise. J Appl Physiol 87, 1213 1219.
42. Wyss JM, Carlson SH & Oparil S (2004). The Pathogenesis of Hypertension. In Basic and Clinical Neurocardiology, ed. Armour JA and Ardell JL, pp. 375. Oxford University Press, New York.